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Improving sensitivity of liquid biopsy using 'loosely stacked' detection layers

By detecting DNA fragments in body fluids like urine, some types of cancer can already be traced in an early stage. But in order to capture them, detection sensitivity has to be improved.

4 Nov 2020

SARS-CoV-2 mutations becoming more contagious

A team of researchers working with Scott Wesley Long from Houston Methodist Hospital and colleagues from Texas, New York, and Illinois studied the patterns of genetic mutations of SARS CoV-2 and its impact on the second wave of infections worldwide.

3 Nov 2020

Adaptive evolution of human coronaviruses may necessitate frequent reformulation of vaccines

Researchers from the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center, USA, have revealed that adaptive evolution in the antigenic regions facilitates seasonal coronaviruses to escape the host immune responses and to cause recurrent infections.

3 Nov 2020

UConn researcher identifies genes and regulatory elements critical to heart development

The advent of genome science has given researchers an unprecedented ability to understand the root causes of a host of conditions.

3 Nov 2020

SARS-CoV-2 spike D614G variant exhibits enhanced replication and transmissibility

A team of scientists from Switzerland, Germany, and the USA has demonstrated that the S-614G variant can easily bind to the human angiotensin-converting enzyme 2 (ACE2), the cellular gateway of SARS-CoV-2. The variant also showed enhanced replication and transmissibility in animal models.

2 Nov 2020

Study: 1 in 8 patients with cancer have inherited gene mutations

Genetic testing can uncover inherited genetic mutations, and could individualize cancer therapies, improve survival, manage cancer in loved ones and push the boundaries of precision medicine.

2 Nov 2020

Potential treatment might make tumors more responsive to immunotherapy

Cancer immunotherapies, which empower patients' immune systems to eliminate tumors, are revolutionizing cancer treatment. Many patients respond well to these treatments, sometimes experiencing long-lasting remissions.

30 Oct 2020

Researchers identify distinct link between autism and brain cell abnormalities

Johns Hopkins Medicine researchers report that new experiments with genetically engineered mice have found clear connections among a range of autism types and abnormalities in brain cells whose chemical output forges platonic (non-sexual) feelings of love and sociability.

30 Oct 2020

Time machine suggests a drug testing approach for pancreatic cancer

Many patients with pancreatic cancer have only about a 10% chance of survival within five years of their diagnosis because they tend to become resistant to chemotherapy, past studies have indicated.

30 Oct 2020

MD65 IgG-YTE shows powerful post-exposure neutralization of SARS-CoV-2

A recent study published in the preprint server bioRxiv in October 2020 describes a reliable animal model to demonstrate the powerful capacity of human neutralizing mAbs directed against SARS-CoV-2 to prevent viral binding the host cell receptor and thus block infection. This indicates the lifesaving value of mAbs in severe COVID-19.

29 Oct 2020

Researchers identify a novel SARS-CoV-2 variant that spread widely across Europe in summer 2020

Researchers from Basel and Spain have identified a novel SARS-CoV-2 variant that has spread widely across Europe in recent months, according to an un-peer-reviewed preprint released this week.

29 Oct 2020

Grant programs will provide $2.2 million to support biomedical research on healthy aging

The Glenn Foundation for Medical Research and the American Federation for Aging Research announce the 2020 recipients of three grant programs: the Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty, the Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research, and the Glenn Foundation for Medical Research Breakthroughs in Gerontology Awards.

28 Oct 2020

Penn researchers awarded $5.4 million to find genetic risk markers for testicular cancer

The international hunt to find more genetic risk markers for testicular cancer is expanding. A team of researchers led by Katherine L. Nathanson, MD, deputy director of the Abramson Cancer Center and the Pearl Basser Professor for BRCA-Related Research in the Perelman School of Medicine at the University of Pennsylvania, was recently awarded $5.4 million over five years from the National Institutes of Health to continue the long-standing genomics work of the TEsticular CAncer Consortium (TECAC).

28 Oct 2020

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

The structure of a 3’ stimulatory pseudoknot in the viral genome or by itself has been proposed recently. Researchers report the structure and mechanisms of mammalian ribosomes during translation of the -1 frameshifting of the SARS-CoV-2 viral genome in a new study published on the preprint server bioRxiv.

28 Oct 2020

WSU research sheds new light on a drug that may be used to treat hypertrophic cardiomyopathy

Research at Washington State University sheds new light on one molecule that may be used to treat a heart condition that can lead to stroke, heart attack and other forms of heart disease.

27 Oct 2020

Inflammasome may play a key role in triggering immune response to cancer

The inflammasome — a protein signaling network that is activated to rid the body of virus or bacteria-infected cells — may play an important role in triggering an immune response to cancer and causing an existing class of drugs to work better against cancers.

27 Oct 2020

Mutation News and Research

Improving sensitivity of liquid biopsy using 'loosely stacked' detection layers

SARS-CoV-2 mutations becoming more contagious

Adaptive evolution of human coronaviruses may necessitate frequent reformulation of vaccines

UConn researcher identifies genes and regulatory elements critical to heart development

SARS-CoV-2 spike D614G variant exhibits enhanced replication and transmissibility

Study: 1 in 8 patients with cancer have inherited gene mutations

Potential treatment might make tumors more responsive to immunotherapy

Researchers identify distinct link between autism and brain cell abnormalities

Time machine suggests a drug testing approach for pancreatic cancer

MD65 IgG-YTE shows powerful post-exposure neutralization of SARS-CoV-2

Researchers identify a novel SARS-CoV-2 variant that spread widely across Europe in summer 2020

Grant programs will provide $2.2 million to support biomedical research on healthy aging

Penn researchers awarded $5.4 million to find genetic risk markers for testicular cancer

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

WSU research sheds new light on a drug that may be used to treat hypertrophic cardiomyopathy

Inflammasome may play a key role in triggering immune response to cancer

Study shows how a genetic mutation causes common sleep syndrome

Study: SARS-CoV-2 virus adopts new strategy to ensure its replication, spread

Simple method provides real-time surveillance to control the spread of drug-resistant gonorrhea

Research shows wrinkled 'super pea' may reduce risk of type 2 diabetes

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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