Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Ludwig study uncovers novel vulnerability in MYC-driven cancers

A Ludwig Cancer Research study has uncovered a novel vulnerability in tumors that are driven by a common cancer gene known as MYC. Such cancers, it found, are highly dependent on the cell's machinery for making fats and other lipids.

22 Aug 2019

Research explains why many psychiatric drugs that work in the lab don’t work in people

Current drug development for neuropsychiatric disorders is in crisis, say experts. More than 90 percent of all drugs that are developed for illnesses like schizophrenia, depression, Alzheimer’s disease (AD), or the brain tumor glioblastoma complete successful trials in mice but then come to a grinding halt in human trials, wasting billions of dollars in drug research. This is partly because of obvious behavioral differences between the two species.

22 Aug 2019

Protein present in telomeres shows global action on genome which influences pleuripotency

Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants.

21 Aug 2019

Protein implicated in neuron growth and cell adhesion appears crucial for pain sensitization

Researchers from Japan's Osaka University have made an important leap in our understanding of how chronic pain conditions develop.

20 Aug 2019

A new perspective on evolution provided by fly testes

The male testes are important areas for biological innovation, as well as being a factory for sperm. In exciting new biological research a team of scientists has found that the testes are also a hotspot for the production ofnew genes.

19 Aug 2019

Influenza A virus host range restricted by dysregulated expression of M gene segment

The host range of the influenza A virus is restricted by dysregulated expression of the M viral gene segment, according to a study published August 15 in the open-access journal PLOS Pathogens by Anice Lowen and John Steel of Emory University School of Medicine, and colleagues.

From PLOS ONE 16 Aug 2019

Simple technique to choose the sex of offspring by separating X and Y sperm

A simple, reversible chemical treatment can segregate X-bearing sperm from Y-bearing sperm, allowing dramatic alteration of the normal 50/50 male/female offspring ratio, according to a new study by Masayuki Shimada and colleagues at Hiroshima University, published on August 13 in the open-access journal PLOS Biology. The study was performed in mice, but the technique is likely to be widely applicable to other mammals as well.

From PLOS ONE 16 Aug 2019

Researchers gain new insights into the mechanism of vaccine-induced T cell immunity

A team led by the Walter Reed Army Institute of Research has gained new insights into the mechanism of vaccine-induced T cell immunity utilizing single-cell RNA sequencing and metabolic profiling techniques.

16 Aug 2019

UAMS Myeloma Center receives $542,486 grant from Leukemia & Lymphoma Society

Brian Walker, Ph.D., with the Myeloma Center at the University of Arkansas for Medical Sciences has received a $542,486, three-year grant from the Leukemia & Lymphoma Society to look at changes in the DNA sequence that effects the development and advancement of multiple myeloma, a cancer of plasma cells in the blood.

12 Aug 2019

Rhythms in gene expression are highly disrupted in the brains of people with schizophrenia

Rhythms in gene expression in the brain are highly disrupted in people with schizophrenia, according to a new University of Pittsburgh-led study.

10 Aug 2019

Researchers identify epigenetic mechanism that may strongly influence healthy aging

Researchers at the Max Delbrueck Center for Molecular Medicine have identified an epigenetic mechanism that appears to strongly influence healthy aging.

9 Aug 2019

Individual differences in pleasure are due to genetic variation, research suggests

Differences in how our brains respond when we're anticipating a financial reward are due, in part, to genetic differences, according to research with identical and fraternal twins published in Psychological Science, a journal of the Association for Psychological Science.

9 Aug 2019

Strong free-electron lasers can be used to break down amyloid protein aggregates

Amyloid fibrils are a type of self-assembled proteins/peptides that take on a stacked sheet-like formation. Amyloid fibril aggregates are known to be a cause of several diseases--including Alzheimer's--and therefore, it is of immense scientific interest to understand how these aggregates can be broken.

8 Aug 2019

New improved model for cancer wasting syndrome cachexia

A new model of cancer-related cachexia promises to help scientists understand why patients with cancer show severe wasting, which in turn may drive the development of better therapies.

7 Aug 2019

Pitt researchers first to grow genetically modified miniature human livers in the lab

Researchers at the University of Pittsburgh School of Medicine are the first to grow genetically modified miniature human livers in the laboratory, to emulate human liver disease progression and test therapeutics.

7 Aug 2019

New mouse model could lead to a better understanding of cachexia syndrome

A study published in Cell Reports Aug. 6 describes the generation of a new mouse model developed at Hollings Cancer Center that could lead to a better understanding of the cachexia syndrome. This wasting condition, characterized by excessive weight loss, has one of the highest incidences in pancreatic cancer patients.

6 Aug 2019

University of North Dakota receives $10 million to expand epigenetics research program

The National Institutes of Health has awarded the University of North Dakota School of Medicine & Health Sciences a $10 million, five-year grant to expand the School's epigenetics research program.

6 Aug 2019

Biomarkers reveal increase in thyroid cancer incidence among WTC responders

The incidence of thyroid cancer among first responders who volunteered or were employed as firefighters, rescue personnel and cleanup workers at Ground Zero in New York on or after September 11, 2001, is three times higher than that in the general population.

5 Aug 2019

Researchers seek to identify biomarkers that may predict suicide risk among women

A four-year, $3.1 million grant from the National Institute of Mental Health will help researchers determine how the stabilization of ovarian hormones estradiol and progesterone may help lower symptoms associated with suicidality among females with longstanding thoughts of suicide.

5 Aug 2019

New computational method reveals genetic patterns in massive jumble of cells

Scientists have devised a new computational method that reveals genetic patterns in the massive jumble of individual cells in the body.

5 Aug 2019

Gene Expression News and Research

Further Reading

Ludwig study uncovers novel vulnerability in MYC-driven cancers

Research explains why many psychiatric drugs that work in the lab don’t work in people

Protein present in telomeres shows global action on genome which influences pleuripotency

Protein implicated in neuron growth and cell adhesion appears crucial for pain sensitization

A new perspective on evolution provided by fly testes

Influenza A virus host range restricted by dysregulated expression of M gene segment

Simple technique to choose the sex of offspring by separating X and Y sperm

Researchers gain new insights into the mechanism of vaccine-induced T cell immunity

UAMS Myeloma Center receives $542,486 grant from Leukemia & Lymphoma Society

Rhythms in gene expression are highly disrupted in the brains of people with schizophrenia

Researchers identify epigenetic mechanism that may strongly influence healthy aging

Individual differences in pleasure are due to genetic variation, research suggests

Strong free-electron lasers can be used to break down amyloid protein aggregates

New improved model for cancer wasting syndrome cachexia

Pitt researchers first to grow genetically modified miniature human livers in the lab

New mouse model could lead to a better understanding of cachexia syndrome

University of North Dakota receives $10 million to expand epigenetics research program

Biomarkers reveal increase in thyroid cancer incidence among WTC responders

Researchers seek to identify biomarkers that may predict suicide risk among women

New computational method reveals genetic patterns in massive jumble of cells

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