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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Understanding transposons provides a new starting point to generate more powerful gene editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases.

27 May 2022

2-Deoxy-D-glucose may inhibit coronaviruses and rhinoviruses

Scientists demonstrated the use of 2-deoxy-D-glucose (2-DG) as a wide-spectrum antiviral agent targeting viruses such as SARS-CoV-2.

27 May 2022

Cell membrane-bound enzyme is essential for SARS-CoV-2 infectivity, study shows

The membrane-bound form of angiotensin converting enzyme 2 (ACE2) is essential for enabling infection with SARS-CoV-2, the virus that causes COVID-19, according to a study published in the journal Cell.

26 May 2022

HMA therapy for patients with myelodysplastic syndrome could potentially activate a sleeping oncogene

Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.

26 May 2022

New Spex NanoSNAP™ provides high performance measurements of nucleic acids and proteins in a snap

New Spex NanoSNAP™ provides high performance measurements of nucleic acids and proteins in a snap.

26 May 2022

Nanotechnology enhanced DNA-chip for SARS-CoV-2 detection with variant differentiation

Researchers differentiated between SARS-CoV-2 variants using nanotechnology.

26 May 2022

Mucosal COVID vaccine candidate powerfully protective in macaques

A recent research paper posted to the bioRxiv* preprint server illustrated the protective efficacy of the intranasal pediatric parainfluenza virus-vectored coronavirus disease 2019 (COVID-19) vaccine prospect, B/HPIV3/S-6P, in macaques.

26 May 2022

A 6.4 million genome analysis predicts dominant SARS-CoV-2 variants

In this new study in the journal Science, researchers have developed a hierarchical Bayesian regression model, named, PyR0, which can analyze the complete set of publicly available SARS-CoV-2 genomes.

26 May 2022

Patient’s perspective on their physical well-being can help better predict cancer treatment outcomes

A breast cancer patient’s perspective on their physical well-being can provide a better indication of their response to cancer treatment than clinician-based tools, a new study has found, highlighting the importance of shared decision-making in the treatment process.

26 May 2022

Study measures viral antigen and inflammatory biomarkers in CSF of COVID-19 patients in relation to neurologic symptoms and disease severity

Researchers investigated the impact of coronavirus disease 2019 (COVID-19) on biomarkers in the cerebrospinal fluid (CSF).

25 May 2022

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

Researchers reviewed available mucosal vaccines discussing the current challenges and ways to advance the existing approaches.

25 May 2022

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor.

25 May 2022

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Researchers used the SARS-CoV-2 sequence against aptamers to perform the in silico selection of an aptamer against the SARS-CoV-2 S protein.

24 May 2022

Study explores the substrate selectivity of the SARS-CoV-2 replicase

Researchers explored factors affecting substrate selection by the SARS-CoV-2 replicase.

24 May 2022

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Researchers assessed the neutralization efficacy of a saRNA vaccine targeting SARS-CoV-2 S protein against reinfection among hamsters with prior vaccination or infection.

24 May 2022

Characterizing spillover dynamics and global transmission patterns of avian influenza A viruses

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24 May 2022

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

What did Stephen Hawking and Mao Zedong have in common? They both suffered from Amyotrophic Lateral Sclerosis (ALS), a cure for which remains elusive. Scientists from Osaka Metropolitan University took an important step toward prevention of ALS and another brain disorder called Frontotemporal dementia (FTD) with their research on the effects of the antibiotic rifampicin on genetically modified mice.

23 May 2022

RNA News and Research

Further Reading

Understanding transposons provides a new starting point to generate more powerful gene editing tools

2-Deoxy-D-glucose may inhibit coronaviruses and rhinoviruses

Cell membrane-bound enzyme is essential for SARS-CoV-2 infectivity, study shows

HMA therapy for patients with myelodysplastic syndrome could potentially activate a sleeping oncogene

New Spex NanoSNAP™ provides high performance measurements of nucleic acids and proteins in a snap

Nanotechnology enhanced DNA-chip for SARS-CoV-2 detection with variant differentiation

Mucosal COVID vaccine candidate powerfully protective in macaques

A 6.4 million genome analysis predicts dominant SARS-CoV-2 variants

Patient’s perspective on their physical well-being can help better predict cancer treatment outcomes

Study measures viral antigen and inflammatory biomarkers in CSF of COVID-19 patients in relation to neurologic symptoms and disease severity

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Study explores the substrate selectivity of the SARS-CoV-2 replicase

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Characterizing spillover dynamics and global transmission patterns of avian influenza A viruses

Antibiotic rifampicin attenuates C9orf72-linked dementia in genetically modified mice

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

Can human coronaviruses infect the GI tract?

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