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Psychological traits may uncover why Alzheimer’s biology differs between patients

In 822 deceased older adults from ROS and MAP, researchers linked stable psychological traits to multi-omic molecular subtypes of Alzheimer’s dementia using postmortem brain tissue from the dorsolateral prefrontal cortex. Neuroticism and loneliness were associated with molecular progression, while purpose in life showed subtype-specific inverse associations, suggesting psychological traits may align with Alzheimer’s biology beyond conventional neuropathology.

22 Jun 2026

Blood proteins reveal which aging cells may raise disease risk

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16 Jun 2026

The cerebellum may help aging brains stay sharper

A large MRI study of more than 47,000 adults found that cerebellar aging is uneven, with posterior association regions and some motor-related areas showing steeper age-related changes. Larger cerebellar volumes were linked to better cognitive performance, supporting a threshold-reserve model in which the cerebellum may help sustain cognition before Alzheimer’s pathology becomes widespread.

11 Jun 2026

Antibody fragment offers safer alternative for Alzheimer disease treatment

In 2025, the European Medicines Agency approved two antibodies for Alzheimer's disease: lecanemab (Leqembi, from Biogen) and donanemab (KisunlaTM, from Eli Lilly and Company), both based on immunotherapy (the use of molecules from the immune system to treat diseases).

5 Jun 2026

Lower Alzheimer’s amyloid levels in Black and Latinx adults

Findings show lower amyloid PET positivity in Black and Latinx adults with cognitive impairment, highlighting disparities in dementia diagnosis and treatment.

1 Jun 2026

Why new Alzheimer’s drugs are dividing regulators worldwide

The Lancet World Report examines why regulators in the US, UK, and Europe have reached different decisions on new amyloid-targeting Alzheimer’s drugs despite evidence that they can modestly slow clinical decline. It highlights the unresolved balance among benefits, safety risks, costs, access, and the need for broader, earlier, and more patient-centered treatment strategies.

31 May 2026

One-time gene editing cuts LDL cholesterol in early hypercholesterolemia trial

A phase 1 NEJM interim analysis found that a single infusion of the investigational base-editing therapy VERVE-102 produced dose-dependent reductions in circulating PCSK9 protein and LDL cholesterol in adults with heterozygous familial hypercholesterolemia or premature coronary artery disease.

26 May 2026

Yoga and meditation show promise for gut health

This systematic review found that yoga and Buddhist meditation were associated with favorable gut microbiota and metabolite profiles in four human studies involving healthy adults. However, because participants largely followed vegetarian or vegan diets and no randomized controlled trials were included, the findings cannot prove that meditation alone reshapes the gut microbiome.

24 May 2026

Poor sleep may flag early Alzheimer’s risk in genetically vulnerable older women

Poorer subjective sleep quality was linked to worse visual memory and greater limbic tau burden in older women with higher genetic risk for Alzheimer’s disease. The findings suggest sleep complaints may help identify women at elevated risk for early AD-related brain and cognitive changes, but larger longitudinal studies are needed.

20 May 2026

Study explains how APOE2 gene protects the brain against Alzheimer's disease

People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly protected against Alzheimer's disease, but scientists have struggled to explain why.

13 May 2026

Urges for cardiologists to screen patients for UPF intake

The European Society of Cardiology identifies ultra-processed foods as a key cardiovascular risk, urging a shift in dietary guidelines for better heart health.

11 May 2026

Methylmercury may harm metabolism beyond its known neurological effects

Methylmercury can accumulate in water environments and enter the food chain. Human exposure is of particular concern in communities affected by contaminated rivers, industrial pollution, artisanal gold mining and environmental disasters.

7 May 2026

Blood tests years before pregnancy predict risk of hypertension

Pre-pregnancy blood biomarkers linked to hypertension risk highlight the potential for early intervention in managing hypertensive disorders of pregnancy.

5 May 2026

Routine blood tests years before conception may predict pregnancy risks

Small abnormalities in blood sugar, blood lipids and inflammation several years before pregnancy are linked to an increased risk of high blood pressure during pregnancy and pre-eclampsia, according to a new study from Karolinska Institutet published in JAMA Network Open.

30 Apr 2026

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026

Alzheimer's risk gene APOE4 impacts bone health in females

Scientists at the Buck Institute for Research on Aging, along with collaborators at UC San Francisco, have discovered that APOE4, the most common genetic risk factor for Alzheimer's disease, causes bone quality deficits specifically in female mice, through a mechanism that is invisible to standard imaging and can emerge as early as midlife.

13 Apr 2026

Triglyceride-lowering drug olezarsen fails to reduce arterial plaque

Despite experiencing significant reductions in triglycerides, patients with triglycerides over 150 mg/dL and a high risk of atherosclerosis did not experience any significant change in the amount of non-calcified plaque in their coronary arteries after taking the triglyceride-lowering drug olezarsen, in a one-year sub-study presented at the American College of Cardiology's Annual Scientific Session.

30 Mar 2026

APOE4 alters brain immunity and cognition differently in females and males

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.

29 Mar 2026

Updated heart guidelines urge earlier screening for high blood cholesterol

For the first time since 2018, a clinical guideline from the American College of Cardiology and the American Heart Association for screening and managing blood cholesterol levels has been updated and jointly published in the Journal of the American College of Cardiology and Circulation.

27 Mar 2026

New cholesterol guidelines emphasize earlier risk assessment and prevention

New national guidance for managing cholesterol and other blood lipids emphasizes earlier risk assessment, more personalized treatment, and long-term prevention—including, in some cases, treatment beginning as early as age 30.

23 Mar 2026