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New molecular signatures map the stepwise development of gastric cancer

Gastric cancer often develops through a gradual sequence of changes, beginning with superficial gastritis and advancing through chronic atrophic gastritis, intestinal metaplasia, and precancerous lesions before culminating in malignancy.

22 Sep 2025

CHI3L1 emerges as a powerful biomarker for liver disease diagnosis and management

The identification of Chitinase-3-like protein 1 (CHI3L1) as a crucial biomarker in liver disease is revolutionizing how clinicians approach the diagnosis, monitoring, and treatment of various liver conditions.

22 Aug 2025

Carriers of colibactin-producing E. coli face threefold increase in colorectal cancer risk

Researchers from Kyoto Prefectural University of Medicine and collaborating Japanese institutions found that patients carrying colibactin-producing Escherichia coli (pks+ E. coli) in their colon polyps were more than three times as likely to have a history of colorectal cancer compared to those without the bacterium.

22 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Study finds link between epigenetic aging and colorectal cancer risk in postmenopausal women

A new research paper was published in Volume 17, Issue 7 of Aging (Aging-US) on July 7, 2025, titled "Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer."

19 Aug 2025

HOXB13 emerges as a context-dependent regulator in cancer biology

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer.

5 Aug 2025

Eating more ultra-processed food raises your risk of lung cancer

The association between ultra-processed food consumption and lung cancer risk underscores the importance of nutrition in cancer prevention strategies.

4 Aug 2025

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

Researchers discovered that people carrying the APOE ε4 gene variant share a unique immune-related protein signature across their blood, brain, and cerebrospinal fluid—regardless of neurodegenerative disease diagnosis. This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

21 Jul 2025

ATR FTIR spectroscopy shows high accuracy in breast tissue classification

Histopathology is the gold standard in cancer diagnosis. However, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy has shown diagnostic potential in other settings.

18 Jul 2025

Cuproptosis offers new hope for treating inflammatory bowel disease and colorectal cancer

Cuproptosis represents a novel mechanism of cell death characterized by intracellular copper ion accumulation.

18 Jul 2025

Explainable AI helps decode the substrate specificity of γ-secretase enzyme

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research.

11 Jul 2025

Pesticides found to disrupt specific gut bacteria linked to inflammation

While emerging evidence suggests pesticides can be toxic to the mix of microorganisms in the digestive system, a new study is the first to map changes to specific gut bacteria based on interactions between human microbes and insect-killing chemicals observed in the lab and an animal model.

27 Jun 2025

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and linked to tumor progression, but its role in lung squamous-cell carcinoma (LUSC) remained unclear.

11 Jun 2025

Switching to a low fat diet slows pancreatic precancer development in mice

Pancreatic cancer is one of the deadliest forms of cancer, killing 87% of patients within five years. Previous studies have shown that obesity can increase pancreatic cancer risk by around 50%.

4 Jun 2025

Gene expression study reveals clues to asbestos-linked mesothelioma

Gene expression leading to alterations in the DNA caused by asbestos exposure may explain the development of Malignant Pleural Mesothelioma (MPM), a rare and aggressive cancer.

31 May 2025

Large global study links higher alcohol intake to increased pancreatic cancer risk

A pooled analysis of over 2.4 million adults across four continents shows a modest but significant increase in pancreatic cancer risk with higher alcohol consumption. The risk is especially pronounced for beer and liquor, and at higher intake levels in men and women.

25 May 2025

Machine learning tool identifies metabolic clues in colorectal cancer

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

22 May 2025

Study uncovers 'cell of origin' of the second most common lung cancer

The 'cell of origin' of the second most common lung cancer and the way that it becomes dominant in the lung have been discovered, in a new study in mice and humans from researchers at UCL, the Wellcome Sanger Institute and the University of Cambridge.

2 May 2025

Can folic acid prevent or promote breast cancer? It depends on dose and DNA

Folic acid plays a dual role in breast cancer depending on dose and context. While moderate intake may reduce risk, high levels or genetic variants disrupting metabolism may promote tumor progression via altered DNA methylation.

30 Apr 2025

Breast cancer deaths decline in young women across all racial and subtype groups

From 2010 to 2020, breast cancer deaths among women ages 20-49 declined significantly across all breast cancer subtypes and racial/ethnic groups, with marked declines starting after 2016, according to an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) registry presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, held April 25-30.

29 Apr 2025

Carcinogenesis News and Research

New molecular signatures map the stepwise development of gastric cancer

CHI3L1 emerges as a powerful biomarker for liver disease diagnosis and management

Carriers of colibactin-producing E. coli face threefold increase in colorectal cancer risk

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Study finds link between epigenetic aging and colorectal cancer risk in postmenopausal women

HOXB13 emerges as a context-dependent regulator in cancer biology

Eating more ultra-processed food raises your risk of lung cancer

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

ATR FTIR spectroscopy shows high accuracy in breast tissue classification

Cuproptosis offers new hope for treating inflammatory bowel disease and colorectal cancer

Explainable AI helps decode the substrate specificity of γ-secretase enzyme

Pesticides found to disrupt specific gut bacteria linked to inflammation

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

Switching to a low fat diet slows pancreatic precancer development in mice

Gene expression study reveals clues to asbestos-linked mesothelioma

Large global study links higher alcohol intake to increased pancreatic cancer risk

Machine learning tool identifies metabolic clues in colorectal cancer

Study uncovers 'cell of origin' of the second most common lung cancer

Can folic acid prevent or promote breast cancer? It depends on dose and DNA

Breast cancer deaths decline in young women across all racial and subtype groups

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