Drug Abuse News and Research

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AI-created miniproteins show promise for targeting hard-to-treat diseases

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

21 May 2026

Key neural circuit helps the brain “change gears”

Most people have experienced the feeling: switching from one task to another, only to find the brain momentarily stuck in the old mode of thinking. Sometimes, even after realizing a strategy no longer works, the mind keeps returning to it anyway.

21 May 2026

Switching to pod-based e-cigarette could improve the odds of quitting smoking

Cigarette smoking is the leading preventable cause of death in the United States, even as rates of cigarette smoking have fallen to an all-time low of approximately 10% in 2024.

19 May 2026

Combination therapy shows promise in maintaining lower suicidal thoughts over time

New research published online today in the American Journal of Psychiatry finds that low-dose buprenorphine, given after a single ketamine infusion, significantly sustained reductions in suicidal ideation in adults with major depressive disorder.

19 May 2026

Teen smoking risks vary between disadvantaged rural and urban communities

Teens in disadvantaged neighborhoods are more likely to smoke, but it depends on whether they live in rural or urban areas.

13 May 2026

GLP-1 weight-loss drugs modulate brain reward circuits to suppress eating for pleasure

A National Institutes of Health (NIH)-funded study has found that an emerging class of GLP-1 weight-loss drugs suppress eating for pleasure, or hedonic feeding, in mice by modulating a reward circuit deep within the brain.

6 May 2026

Cannabis leads microdosing trends among U.S. adults, study finds

Researchers from University of California San Diego have found that microdosing - taking very small amounts of psychoactive substances - is more common among U.S. adults than previously recognized, with cannabis leading by a wide margin.

4 May 2026

EVALI outbreak reshaped public perceptions of e-cigarette harm

Cigarettes are one of the deadliest products on the market – but the risks of alternatives are not always clearly understood.

4 May 2026

Combining cannabis edibles and alcohol significantly increases driving impairment

In a study supported by the National Institute on Drug Abuse of the National Institutes of Health, Johns Hopkins Medicine researchers added to evidence that using cannabis edibles and alcohol together worsens driving impairment compared with consuming either substance alone.

4 May 2026

Finding new ways to mimic ketamine’s antidepressant effects

Weill Cornell Medicine investigators have "reverse engineered" ketamine's antidepressant effects to identify potential new strategies for treating depression.

4 May 2026

U.S. dentists still prescribe opioids at higher rates globally

People getting their teeth pulled or drilled by dentists in the United States are still much more likely to get powerful opioid medications than dental patients in other developed countries or even the U.S. territory of Puerto Rico, a new study finds.

23 Apr 2026

Teen cannabis use linked to slower growth in memory and thinking

Researchers from University of California San Diego have found that teenagers who begin using cannabis show slower gains in thinking and memory skills as they grow. The study, published on April 20, 2026 in Neuropsychopharmacology, analyzed data from more than 11,000 participants in the Adolescent Brain Cognitive Development (ABCD) Study, the largest long-term study of brain development in U.S. youth.

20 Apr 2026

US Medicaid data finds buprenorphine safe for long-term child development

Children born to mothers who used buprenorphine for opioid addiction during pregnancy do not have a greater risk of neurodevelopmental disorders, such as ADHD and autism, compared with children whose mothers took methadone, finds a large US study published by The BMJ today.

17 Apr 2026

Prenatal opioid exposure shows minimal effect on later academic performance

Every 25 minutes in the United States, a baby is diagnosed with neonatal abstinence syndrome (NAS), a condition that occurs in newborns who have been exposed to opioids in the womb and develop withdrawal after birth, according to the Centers for Disease Control and Prevention.

13 Apr 2026

Expanded Medicaid improved access to buprenorphine for opioid use disorder

Medicaid insurance expansions between 2017 and 2023 sharply increased access to medication treatment for opioid use disorder in a period when fatal overdoses continued to climb, according to Rutgers Health researchers.

6 Apr 2026

Highly potent opioid shows potential as therapy for pain and opioid use disorder

Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder.

1 Apr 2026

Study links smokable drug use to heightened incidence of severe burns

A new analysis in Oregon reveals a heightened incidence of severe burns requiring hospital-level care as illicit drug use has shifted nationwide from injection to smoking.

16 Mar 2026

Weekly buprenorphine injections improve opioid abstinence during pregnancy

In a clinical trial supported by the National Institutes of Health (NIH), a research team found that administering weekly injectable extended-release buprenorphine for treatment of opioid use disorder (OUD) during pregnancy led to higher rates of abstinence from illicit opioids than buprenorphine given daily under the tongue (sublingual), one of the standard methods of treatment.

16 Mar 2026

High medical debt leads to significant delays in routine and preventive care

Medical debt is associated with deferred dental care, medical care, and mental health care, even among people with health insurance, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

11 Mar 2026

Long-read whole genome sequencing uncovers new genetic variants linked to autism

Researchers at the University of California San Diego have identified new genetic variants associated with autism spectrum disorder (ASD) by using long-read whole genome sequencing (LR-WGS), an emerging approach that reads large sections of the genome at once, making it easier for scientists to find new genetic variants and understand how genetic variants affect the function of a gene.

9 Mar 2026