Fertilization News and Research

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Endometriosis increases risk of some birth defects in infants

Research indicates women with endometriosis may face a higher risk of congenital anomalies in infants, emphasizing the need for further investigation.

13 May 2026

Loss of X chromosome linked to female infertility risk

Chromosomes carry genetic information for biological sex, which generally assigns women two X chromosomes and men XY chromosomes.

12 May 2026

Calla Lily Clinical Care doses first patients in clinical trial for intravaginal drug delivery platform for threatened miscarriage

Calla Lily Clinical Care, a women’s health-focused medical technology company, today announced dosing of the first patients in the FREEDOM clinical trial.

6 May 2026

Research suggests randomness behind rare cases of twin ovulation

Each month during a woman's menstrual cycle, an ovary prepares 10-20 antral follicles, fluid filled sacs that hold immature eggs, for maturation.

22 Apr 2026

Stem cell model recreates early human embryo with yolk sac

For the first time, a stem cell model has produced a structure resembling an early human embryo with a yolk-sac-like structure, from a single starting stem cell population and without direct genetic manipulation.

21 Apr 2026

As US birth rate falls, feds’ response may make pregnancy more dangerous

The number of babies born in the United States fell again last year.

17 Apr 2026

New cell atlas reveals biological links to pregnancy complications

The biological connection between a pregnant woman and her developing baby has been mapped in unprecedented detail by UC San Francisco scientists, revealing new cell types and insights into conditions such as preeclampsia, preterm birth, and miscarriage.

8 Apr 2026

Polygenic embryo testing raises ethical concerns beyond disease prevention

For more than four decades, in vitro fertilization (IVF) has helped families have children. Scientists estimate that more than 10 million people worldwide have been born through IVF and related assisted reproductive technologies, according to the International Committee for Monitoring Assisted Reproductive Technologies.

31 Mar 2026

Microgravity reduces the ability of sperm to navigate reproductive tracts

Having a baby in space may require a bit more direction, with new Adelaide University research revealing the navigational abilities of sperm are negatively impacted by a lack of gravity.

26 Mar 2026

Fertility treatments linked to small increases in some cancers

Findings indicate small increases in certain cancers linked to assisted reproduction, though overall cancer incidence aligns with the general female population.

13 Mar 2026

Targeted mRNA delivery restores sperm production and fertility in infertile mice

Researchers have found that targeted delivery of messenger RNA (mRNA) can restore sperm production and fertility in genetically infertile male mice.

5 Mar 2026

Repurposed kidney drug finerenone shows promise in treating premature ovarian insufficiency

Premature ovarian insufficiency (POI) is a clinically significant cause of infertility that affects between 1 to 3% of women of childbearing age.

5 Mar 2026

Optically invisible culture dishes improve embryo imaging in IVF

Selecting the healthiest embryo is one of the most important steps in in‑vitro fertilization (IVF), yet it remains one of the most uncertain.

4 Feb 2026

IVF study finds shorter insemination protects embryo availability without harming success

Short-term sperm–oocyte co-incubation during IVF cycles with only one or two retrieved oocytes produced cumulative live birth rates comparable to conventional overnight insemination. It also improved fertilisation metrics and reduced cancellation or no-embryo cycles, suggesting practical laboratory advantages without improving overall live birth probability.

4 Feb 2026

Natural ovulation offers a safer path to IVF success

Researchers compare the effects of natural ovulation and external hormone replacement regimens for preparing the uterus before frozen embryo transfer.

4 Feb 2026

Targeted uterine mRNA treatment boosts fertility outcomes in mice

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine - which designs nanotechnology-based platforms for clinical translation across specialties - developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.

22 Jan 2026

Age-related sperm changes at imprint regions linked to autism risk

A new research paper was published in Volume 17, Issue 12 of Aging-US on December 29, 2025, titled "Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring."

16 Jan 2026

Can ketogenic diets help PCOS? New analysis points to weight and insulin gains

A systematic review and meta-analysis of 15 studies found that ketogenic diets were associated with short-term reductions in body weight, waist circumference, insulin resistance, and some reproductive hormones in women with polycystic ovary syndrome, primarily among those with overweight or obesity. However, substantial heterogeneity, low certainty of evidence, limited safety reporting, and short follow-up periods mean the clinical effectiveness and long-term sustainability of ketogenic diets in PCOS remain uncertain.

5 Jan 2026

Private equity firms increasingly dominate fertility clinics in the United States

The rise of private equity firms investing in health care facilities across the United States has been exploding in the last decade.

30 Dec 2025

Engineered womb lining model opens a window into embryo implantation

By engineering a system replicating the womb lining with high biological accuracy, researchers at the Babraham Institute and Stanford University have been able to study the implantation of human embryos, opening up this enigmatic process to investigation.

23 Dec 2025