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Why metformin could protect the brain by rewiring mitochondria

Metformin boosts human oligodendrocyte differentiation and myelination across stem-cell, organoid, and chimera models. The study links these effects to mitochondrial metabolic shifts, supporting its potential as a therapy for multiple sclerosis.

1 Sep 2025

How cohesin mechanics and nanotracker tech are redefining DNA research

Discover how cohesin mechanics and nanotracker technology are transforming DNA research in this Bruker webinar.

From Bruker Nano Surfaces and Metrology 19 Aug 2025

GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

A Cell Metabolism study reveals that GIPR signaling in oligodendrocytes enhances brain access and weight-loss efficacy of GLP-1R agonists by increasing vascular permeability and targeting appetite-regulating neurons. This mechanism may explain why GIPR/GLP-1R co-agonists outperform single-agent therapies.

14 Aug 2025

New blood test offers breakthrough in myeloma diagnosis and monitoring

Researchers at Dana-Farber Cancer Institute have developed a blood test that could transform the diagnosis and monitoring of multiple myeloma (MM) and its precursor conditions.

8 Aug 2025

Standard DNA tests miss most cases of NUT carcinoma

The diagnosis of a suspected lung, head, and neck cancer called NUT carcinoma should include additional testing capable of detecting gene fusions that are definitive markers of the disease, according to a study by Dana-Farber Cancer Institute investigators.

24 Jul 2025

Gut bacteria send direct signals to the brain to stop you from overeating

Researchers have discovered a novel gut-brain sensory circuit in mice where specialized colonic cells sense bacterial flagellin and rapidly suppress feeding via the vagus nerve. This "neurobiotic sense" operates independently of immune pathways, revealing a direct neural mechanism for microbiota-host communication.

24 Jul 2025

ANXA2 positive hepatocytes drive migration based repair in acute liver failure

Acute liver failure (ALF) represents a life-threatening condition marked by rapid deterioration of liver function, often necessitating urgent liver transplantation.

18 Jul 2025

Weight loss wipes out senescent fat cells but leaves immune scars, study finds

Researchers have mapped human fat tissue at single-cell resolution, uncovering how obesity alters cellular stress, inflammation, and tissue structure. Weight loss reverses much of this damage, especially senescence in fat and vascular cells, but leaves some immune dysfunction behind.

10 Jul 2025

Salivary enzyme levels rise with gene variation in diabetics

This research highlights the association between AMY1 gene copy number and salivary enzyme activity, with implications for glucose homeostasis in diabetes.

8 Jul 2025

Study maps HER2 mutations in lung cancer patients from Northeastern Brazil

A new research paper was published in Volume 16 of Oncotarget on June 17, 2025, titled "Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights."

27 Jun 2025

Uncommitted cells offer clues to neuroblastoma regression

Neuroblastoma is a cancer that affects the sympathetic nervous system of children. It is unusual among cancers because it shows a range of outcomes: from aggressive, potentially fatal progression to a unique phenomenon where the tumor spontaneously regresses even without treatment.

25 Jun 2025

Blocking a single enzyme rewires limb regrowth in axolotls

Researchers uncovered how CYP26B1-mediated retinoic acid (RA) breakdown determines segment identity during axolotl limb regeneration. Disrupting RA degradation reprograms blastema cells, revealing the molecular controls of precise limb regrowth.

11 Jun 2025

Spatial transcriptomics could transform musculoskeletal research

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context.

9 Jun 2025

New mask technology balances protection and comfort effectively

The COVID-19 pandemic increased public awareness of the importance of mask use for personal protection.

21 May 2025

Light-induced DNA detection technique enables rapid, ultra-sensitive genetic analysis

PCR genetic analysis has been in the spotlight since COVID-19, but light is now further facilitating PCR-free methods.

22 Apr 2025

Multiple myeloma care improved using innovative optical genome mapping

Researchers have demonstrated the potential of the innovative optical genome mapping (OGM) technique for the diagnosis, prognosis, and therapeutic management of multiple myeloma.

15 Apr 2025

Chronic cocaine use increases impulsivity

Findings indicate chronic cocaine use alters brain circuits, increasing impulsivity in low-impulsive rats, contradicting previous assumptions about addiction.

5 Mar 2025

Advancements in molecular diagnostics for hematopoietic and lymphocytic neoplasms

Hematopoietic and lymphocytic neoplasms (HLNs) are a diverse group of malignancies affecting blood and lymphatic systems, with outcomes varying from manageable conditions to fatal diseases.

27 Feb 2025

Takumi-shaped DNA hydrogels show promise for targeted therapies

Hydrogels are polymeric materials with three-dimensional network structures containing large amounts of water. They serve as sustained-release drug delivery systems as they can encapsulate various bioactive substances, including drugs, antigens, and even cells.

13 Feb 2025

Age-related decline in cardiac conduction system regeneration increases arrhythmia risk after heart attack

Study uncovers the impact of myocardial infarction on the cardiac conduction system, revealing insights into arrhythmogenesis and potential therapeutic targets.

8 Jan 2025