Inflammaging News and Research

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How diet affects aging metabolism differently for men and women

Research reveals sex-based differences in diet's impact on metabolism, highlighting plant proteins for men and moderate wine for women in older adults.

7 Nov 2025

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Urolithin A, a natural postbiotic known to trigger mitophagy, rejuvenated key immune cell functions in healthy middle-aged adults after 28 days. The trial showed a shift toward a youthful, energy-efficient CD8⁺ T-cell profile and enhanced bacterial clearance without inflammatory side effects.

3 Nov 2025

How shifting antibodies fuel aging and the new therapies aiming to slow it

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, glycosylation changes, and Fc receptor pathways, it reveals immunoglobulins as both biomarkers and potential therapeutic targets in aging.

14 Oct 2025

Cocoa extract supplements linked to reduced inflammation in older adults

Could cocoa extract supplements rich in cocoa flavanols reduce inflammation and, in turn, prevent age-related chronic diseases? In a new study from the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), investigators from Mass General Brigham and their colleagues looked at changes in five age-related markers of inflammation among participants who received daily cocoa supplements over several years.

17 Sep 2025

Study reveals how centenarians preserve youthful immune defenses

Researchers mapped immune cells from centenarians, their offspring, and younger controls across three cohorts using multi-omics single-cell profiling. They found that centenarians retain leaner helper pools but have enhanced cytotoxic and NK cell programs, along with reinforced NK–T communication networks.

15 Sep 2025

Scientists explore hookworm proteins as potential treatment for inflammation

It's been a long-accepted reality that with age comes increased inflammation – so widely accepted it's been dubbed "inflammaging."

21 Aug 2025

Immune aging drives the progression of type 2 diabetes

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell failure.

6 Aug 2025

New research links age-related gene changes to symptom decline

UCSF researchers have found that certain antiviral genes become less active over time in lupus, revealing why some patients see their symptoms fade as they age.

29 Jul 2025

Study reveals how aging alters liver function and structure

The aging liver undergoes dramatic changes in its functional organization and other key attributes, which may underpin its increasing susceptibility to disease, according to a study led by investigators at Weill Cornell Medicine.

17 Jul 2025

Viome and Scripps Research join forces to develop at-home RNA test for colon cancer prevention

Viome Life Sciences, the leader in AI-powered, RNA-based diagnostics and precision nutrition and Scripps Research, the leader in accelerating the impact of fundamental research on human health, today announced a strategic partnership to develop and clinically validate the first at-home RNA test designed to detect precancerous colon polyps, enabling early prevention of colorectal cancer.

14 Jul 2025

Fasting triggers neuroprotective changes that could delay dementia

Intermittent fasting could be a neuroprotective strategy, improving gut-brain axis function and reducing inflammation linked to neurodegenerative diseases.

11 Jul 2025

Inflammaging may be a lifestyle phenomenon rather than a universal aging trait

Inflammation, long considered a hallmark of aging, may not be a universal human experience, according to a new study from Columbia University Mailman School of Public Health.

1 Jul 2025

Unlocking the secrets of human longevity and healthy aging

Human healthy aging and longevity are complex phenomena influenced by a dynamic interplay of genetic, epigenetic, metabolic, immune, and environmental factors.

22 May 2025

How immune resilience and salutogenesis promote disease resistance and longevity

Researchers examine how salutogenesis, the active production of health through immune resilience, resists disease.

28 Apr 2025

Reducing cardiometabolic risk and inflammation with pomegranate

Pomegranate extract shows promise in lowering systolic blood pressure and inflammatory markers, highlighting its role in promoting healthy aging for adults 55+.

4 Apr 2025

Skipping exercise? Just sitting less may still improve your metabolic health

Older adults who limit their sedentary time have lower metabolic syndrome risk, regardless of how active they are or how healthy they eat. Even light movement can support better metabolic health when replacing prolonged sitting.

24 Mar 2025

Mitochondria may hold key to reducing inflammaging in aging cells

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and enables the healing of the many bumps, bruises and scrapes along the way.

14 Mar 2025

Integrated anti-aging strategy could reduce neurodegeneration

Aging significantly impacts neurodegeneration, increasing risks for diseases like Alzheimer's. Research focuses on therapies to enhance cognitive function.

11 Mar 2025

Exploring the role of gut microbes in the aging process

Aging is a universal and complex process affecting all organisms, characterized by several genetic hallmarks such as telomere attrition, genomic instability, and epigenetic changes.

9 Oct 2024

Study sheds light on the dual nature of cellular senescence

Scientists at Sanford Burnham Prebys and the La Jolla Institute for Immunology have revealed a new secret regarding senescence, a cellular state similar to sleep that is more likely to affect aged cells.

22 Aug 2024