Retinoic Acid News and Research

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Retinoic Acid is a nutrient that that body needs in small amounts to function and stay healthy. All-trans retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of all-trans retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). All-trans retinoic acid is being studied in the prevention and treatment of other types of cancer. Also called ATRA, retinoic acid, tretinoin, and vitamin A acid.

Researchers identify a new treatment strategy for neuroblastoma

Researchers at Karolinska Institutet and Lund University in Sweden have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer.

16 Jun 2025

Blocking a single enzyme rewires limb regrowth in axolotls

Researchers uncovered how CYP26B1-mediated retinoic acid (RA) breakdown determines segment identity during axolotl limb regeneration. Disrupting RA degradation reprograms blastema cells, revealing the molecular controls of precise limb regrowth.

11 Jun 2025

Novel strategy for treating acute myelogenous leukemia identified

A Ludwig Cancer Research study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive blood cancer for which the median survival time following diagnosis remains just 8.5 months.

16 Apr 2025

Discovery of special dendritic cells sheds light on food allergy prevention

The immune system must be able to quickly attack invaders like viruses, while also ignoring harmless stimuli, or allergies can result. Immune cells are known to ignore or "tolerate" molecules found on the body's own healthy cells, for instance, as well as nonthreatening substances from outside the body like food.

15 Apr 2025

Naturally occurring molecule suppresses appetite and promotes weight loss

A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide - also known as Ozempic - in suppressing appetite and reducing body weight.

6 Mar 2025

St. Jude scientists discover how retinoic acid selectively kills metastatic neuroblastoma cells

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10-15%.

2 Mar 2025

Unexpected viral reservoir: influenza A thrives in cattle mammary glands

Researchers uncover how influenza A virus infects dairy cattle, revealing the mammary gland's surprising role in viral replication and transmission through milk.

15 Jan 2025

Kaempferol boosts immune tolerance and fights allergies

Kaempferol's role in Treg development is linked to Aldh1a2 activation in dendritic cells, highlighting its potential in suppressing inflammation and allergies.

19 Dec 2024

Flavonoid kaempferol could offer natural relief for food allergies

Allergic diseases such as asthma, atopic dermatitis, and food allergies have been increasing in frequency over the last few years.

16 Dec 2024

New drug shows promise for motor neurone disease treatment

A pioneering study published in the International Journal of Molecular Sciences by researchers at Durham University has revealed promising results for a new treatment targeting motor neurone disease (MND).

22 Oct 2024

CRISPR-based rapid molecular diagnostic developed for two forms of leukemia

Researchers at Dana-Farber Cancer Institute have created a CRISPR-based rapid molecular diagnostic for two forms of leukemia that are driven by mutations that involve gene fusions.

9 Oct 2024

Study reveals how morphogens and cell adhesion create sharp tissue boundaries

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, demonstrate how morphogens combined with cell adhesion can generate tissue domains with a sharp boundary in an in vitro model system.

8 Oct 2024

Hair follicles use unique sensor system to clean up dead cells

Billions of our cells die every day to make way for the growth of new ones. Most of these goners are cleaned up by phagocytes - mobile immune cells that migrate where needed to engulf problematic substances.

21 Aug 2024

COVID-19 linked to rise in autoimmune lung disease, study finds

A study in eBioMedicine identifies shared immunopathology between SARS-CoV-2 infection and MDA5 autoimmunity, highlighting a surge in MDA5+ cases and interstitial lung disease during the COVID-19 pandemic.

15 May 2024

Study reveals key gut microbiome differences in prediabetic patients

Study explores the differences in gut microbiome composition between prediabetic patients and healthy individuals, revealing significant variations that correlate with altered metabolic functions and potential diabetes progression.

11 Apr 2024

New research identifies potential drug target to prevent kidney failure

A new study found that retinoic acid receptors (RARa) in the proximal tubules of the kidney play a crucial role in limiting the damaging effects of kidney injury that often lead to kidney failure.

9 Mar 2024

Largest genetic study on circulating retinol reveals new insights into its impact on health

Study presents the largest genome-wide association analysis on circulating retinol, identifying genes beyond the primary transport system that influence retinol levels and its broad impacts on health, including potential protective roles against schizophrenia and effects on various clinical phenotypes.

21 Feb 2024