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New data hub aims to advance alternatives to animal testing

A research team at NYU Langone Health and Sage Bionetworks has been awarded a $25 million grant to establish the data hub and coordinating center for the National Institutes of Health's Complement-Animal Research in Experimentation (Complement-ARIE) program.

18 Mar 2026

Study identifies brain pathway crucial for proper functioning of working memory

Working memory is a cognitive function that is essential for carrying out everyday activities and temporarily retaining information.

17 Mar 2026

Unmasking the hyperactive circuitry of early Alzheimer’s

Neuroscientists at King's College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer's disease.

9 Mar 2026

Long COVID taste loss tied to reduced expression of key taste genes

The study identifies molecular changes in taste receptor cells as a potential cause of persistent taste dysfunction in long COVID-19, impacting quality of life.

5 Mar 2026

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Researchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.

26 Feb 2026

Aging brains struggle to recycle synaptic proteins

As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren't sure why.

2 Feb 2026

Shared genetic architecture links schizophrenia with hemispheric white matter microstructure

Schizophrenia is a highly heterogeneous psychiatric disorder affecting ~1% of the global population, typically emerging in adolescence or early adulthood and characterized by hallucinations, delusions, disorganized thinking, and cognitive impairments; while its etiology remains elusive, genetic factors are widely recognized as fundamental, and GWAS have identified over 200 genome-wide significant loci.

24 Jan 2026

Ageing slows brain protein clearance and shifts synaptic waste to microglia

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

22 Jan 2026

Struggling to make ends meet may slow brain development in infants

Researchers identify specific psychosocial factors that strongly correlate with altered brain development within the first year of life.

12 Jan 2026

The gut is not just digestive and new evidence shows it actively controls brain function

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

6 Jan 2026

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

In our latest interview, News-Medical speaks with Rosanna Zhang from ACROBiosystems about utilizing organoids for disease modeling in the field of neuroscience research.

From ACROBiosystems 6 Jan 2026

Biomimetic brain modeling mirrors animal learning and neural dynamics

A new computational model of the brain based closely on its biology and physiology not only learned a simple visual category learning task exactly as well as lab animals, but even enabled the discovery of counterintuitive activity by a group of neurons that researchers working with animals to perform the same task had not noticed in their data before, said a team of scientists at Dartmouth College, MIT, and the State University of New York at Stony Brook.

30 Dec 2025

Synapse News and Research

New data hub aims to advance alternatives to animal testing

Study identifies brain pathway crucial for proper functioning of working memory

Unmasking the hyperactive circuitry of early Alzheimer’s

Long COVID taste loss tied to reduced expression of key taste genes

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Aging brains struggle to recycle synaptic proteins

Shared genetic architecture links schizophrenia with hemispheric white matter microstructure

Ageing slows brain protein clearance and shifts synaptic waste to microglia

Struggling to make ends meet may slow brain development in infants

The gut is not just digestive and new evidence shows it actively controls brain function

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

Biomimetic brain modeling mirrors animal learning and neural dynamics

Engineered sensor reveals the brain’s hidden chemical conversations

Scientists discover rapid synapse adaptation in neuronal communication

How brain cells manage long distance genetic instructions

Brainwide circuitry mapping reveals how psilocybin drives therapeutic neural rewiring

Cocktail of three supplements improves social behaviors in autistic mice

Researchers use "zap-and-freeze" technique to watch hard-to-see brain cell communications

Researchers reveal common synaptic pathway behind Parkinson’s and Alzheimer’s diseases

Neuroscientists uncover a surprising role for "Frazzled" protein in the nervous system of fruit flies

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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