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Thermodynamic insights into histamine H1 receptor ligand binding

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs.

13 Feb 2026

Accelerating kinase drug discovery with validated kinase activity assay kits

The development of new therapeutics targeting protein kinases is crucial in the fight against diseases like cancer.

From Eurofins Discovery 20 Jan 2026

Insulin anxiety and workplace barriers complicate gestational diabetes care

Insulin use in gestational diabetes presents challenges; education and support are key to overcoming fears and ensuring effective self-management for mothers.

20 Jan 2026

Novel triple receptor agonist shows potent efficacy in lowering high triglycerides

In a small, short duration trial (12 weeks), a new medication called DR10624 reduced triglyceride levels in most patients with severe hypertriglyceridemia by more than 60%, according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

11 Nov 2025

Cannabis extract eases chronic back pain and improves quality of life in major clinical trial

A phase 3 trial in Nature Medicine found that a full-spectrum Cannabis sativa extract (VER-01) significantly reduced chronic low back pain and improved sleep and function compared with placebo. The extract was safe, well-tolerated, and showed no signs of abuse or dependence, with benefits maintained over long-term treatment.

30 Sep 2025

Gut probiotic Christensenella tenuis reduces endotoxemia and improves metabolism in obese mice

This study is reported by the team of Professor Shuang-jiang Liu from Shandong University. The study reveals that the gut probiotic Christensenella tenuis significantly alleviates endotoxemia and metabolic disorders in a diet-induced obesity (DIO) mouse model by modulating gut bile acids (BAs) metabolism and suppressing lipopolysaccharide (LPS) translocation across the gut barrier.

26 Sep 2025

Closed Loop Medicine launches first personalized GLP-1 dosing platform In U.S.

Closed Loop Medicine Ltd (CLM), a leader in personalized pharmaceutical dosing, today announced the U.S. launch of WeDosify, which enables clinicians to personalize GLP-1 titration at scale.

19 Sep 2025

Trial shows no meaningful gains with mavacamten in nonobstructive hypertrophic cardiomyopathy

Mavacamten treatment at 48 weeks was not associated with significant improvements in patient-reported health status or peak oxygen consumption compared with placebo in patients with symptomatic nonobstructive hypertrophic cardiomyopathy, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

New trial shows benefit of digitoxin in patients with severe heart failure symptoms

Digitoxin reduced the risk of a composite of all-cause death and hospitalization for worsening heart failure (HF) among patients with advanced HF and a reduced ejection fraction (HFrEF), according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

AI reshapes ARDS care by predicting risk, guiding ventilation, and personalizing treatment

Artificial intelligence and machine learning are transforming acute respiratory distress syndrome (ARDS) management, enabling earlier detection, precision risk stratification, and tailored therapies. Emerging AI techniques promise to improve outcomes, but real-world clinical validation and integration remain critical challenges.

21 Jul 2025

Gut pathogens override chemical repulsion and invade

The research redefines indole's function, showing its exploitation by Salmonella for colonization, highlighting complex bacterial interactions in the gut.

17 Jul 2025

Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Once-weekly amycretin, a novel peptide activating GLP-1, amylin, and calcitonin receptors, produced rapid, substantial, and sustained weight loss in adults with overweight or obesity during a phase 1b/2a trial. The treatment was generally well tolerated, with mostly mild to moderate gastrointestinal side effects, supporting further investigation in larger, longer studies.

23 Jun 2025

Closed Loop Medicine appoints Kate Woolland as CEO

Closed Loop Medicine Ltd. (“CLM”), a leader in pharmaceutical precision dosing, today announced the appointment of Kate Woolland as Chief Executive Officer.

22 May 2025

Black tea kombucha reduces harmful gut microbes linked to obesity

Regular consumption of black tea kombucha for eight weeks beneficially shifted gut microbiota composition in both normal-weight and obese adults.

14 May 2025

Early cardiovascular benefits of semaglutide seen within months in SELECT trial

Semaglutide can rapidly reduce heart attacks and other serious cardiovascular complications in adults with overweight or obesity who have pre-existing cardiovascular disease but not diabetes, according to a secondary analysis of the landmark Semaglutide and Cardiovascular Outcomes (SELECT) trial from the same international author team being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain.

12 May 2025

Understanding the particle drifting effect with Dr. Na Li

Join Dr. Na Li as she explores the mysteries of the particle drifting effect and its practical applications in real-world scenarios.

From Pion Inc 5 May 2025

EEG monitoring helps reduce anesthesia use and improves pediatric recovery

Newly published results of a randomized, controlled clinical trial in Japan among more than 170 children aged 1 to 6 who underwent surgery, show that by using EEG readings of brain waves to monitor unconsciousness, an anesthesiologist can significantly reduce the amount of the anesthesia administered to safely induce and sustain each patient's anesthetized state.

21 Apr 2025

Research challenges traditional oxygen practices in trauma care

When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it's often less than the current standard.

31 Mar 2025

Assessing the impact of the particle drift effect on oral drug absorption using flux tools

Discover how particle drift analysis using flux tools improves oral drug absorption in pharmaceutical research.

From Pion Inc 31 Mar 2025

Insights into drug absorption and predictive modeling with Professor Kiyohiko Sugano

Learn how drug absorption and predictive modeling drive advancements in pharmaceuticals and precision medicine.

From Pion Inc 18 Mar 2025