Cytotoxicity News and Research

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Mtb's exotoxin secretion and trafficking mechanism revealed

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years.

25 Nov 2021

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

In a study published in the journal Scientific Reports, a research group from Brazil showed how antiviral anionic phthalocyanine derivative used in a mouthwash protocol may not only reduce the symptoms of coronavirus disease (COVID-19), but also hamper the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

23 Nov 2021

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

A new study evaluates the efficacy of SNX-5422 as a post-exposure prophylactic treatment.

23 Nov 2021

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

The current study analyzed the interaction of SARS-CoV-2 at the human maternal-fetal interface by using an advanced ex vivo model.

16 Nov 2021

The SARS-CoV-2 Beta variant evades Fc effector function by ancestral strain, study says

A new study finds improved Fc cross-reactivity against certain SARS-CoV-2 variant of concern.

10 Nov 2021

Stenoparib effectively inhibits SARS-CoV-2 variants in vitro

A new study assesses the antiviral activity of stenoparib against four SARS-CoV-2 strains.

10 Nov 2021

Cell-based viral replication system for screening of SARS-CoV-2 drugs

The current study reports a SARS-CoV-2 replicon system within stable cell lines that can be cultured with ease in a standard biosafety level 2 laboratory.

10 Nov 2021

The role of T follicular helper cells in the humoral immune response to SARS-CoV-2

The current analysis indicates that cTfh cells react to the spike antigen following vaccination are associated with anti-S protein neutralizing antibodies.

9 Nov 2021

Hemin as a potential therapy for COVID-19

The current study explores the antiviral activity of HO-1 induced by hemin against SARS-CoV-2 and attempts to describe the mechanism of its anti-viral action.

8 Nov 2021

New system created for targeted delivery of anti-cancer drugs

RUDN University and Shahid Beheshti University (SBU) chemist together with colleagues from Iran created a system for targeted delivery of anti-cancer drugs.

27 Oct 2021

Taking lessons in molecular therapeutics from earthworms to combat COVID

Scientists were interested in further investigating the defense mechanism of earthworms in an effort to discover therapeutic solutions against SARS-CoV-2.

27 Oct 2021

Study finds FDA-approved drug has potent antiviral activity against SARS-CoV-2 and variants of concern

A new study aimed to examine the antiviral potential of atovaquone against the original SARS-CoV-2 strain and other variants of concern.

25 Oct 2021

SARS-CoV-2 cocktail with three antibodies potent in preclinical testing

Amidst growing concerns on the use and potential benefits of convalescent plasma therapy, a research group in the United States has identified three human antibodies (Abs) that, when combined, demonstrate both robust viral suppressive properties against all tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Variants of Concern (VoC) in vitro and profound antiviral efficacy in vivo.

22 Oct 2021

New high-throughput assay could help development of anti-COVID-19 drugs

In a recent study, researchers develop a new high-throughput assay that allows for rapid screening of potential inhibitors.

13 Oct 2021

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

The team has evaluated a low molecular weight chitosan derivative as a candidate preventing the viral entry into mammalian nasal epithelial cells to limit the spread of COVID-19.

12 Oct 2021

Antiviral activity of wheat germ Agglutinin against SARS-CoV-2

A new study reports the antiviral activity of WGA against SARS-CoV-2 and its two Variants of Concern - Alpha and Beta.

4 Oct 2021

Novel Assay Platform for 3D Microfluidic Cancer Research

AMSBIO have supplied custom Chimeric antigen receptor (CAR)-T products to the University of Strathclyde (UoS) in Glasgow, UK, and ScreenIn3D Ltd, allowing them to perform novel immune-oncology assays in 3D microfluidic cancer models.

From AMS Biotechnology 1 Oct 2021

Scientists identify potential antibody candidate with broad-spectrum neutralizing efficacy against SARS-CoV-2 variants

A team of scientists from China and the USA has recently described the antiviral efficacy of a monoclonal antibody candidate targeting the spike receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Importantly, they have observed that emerging spike mutations could not affect the potency of this antibody. The study is currently available on the bioRxiv* preprint server.

27 Sep 2021

Hyperbranched polylysine nanopolymer as potential broad-spectrum antiviral against SARS-CoV-2

The findings from this study suggest that HPNs may inhibit viral replication and budding.

27 Sep 2021

Study shows how SARS-CoV-2 viral proteases can be targeted to stop virus replication

Researchers at the University of Liverpool have shown how SARS-CoV-2 viral proteases attack the host cell, and how this can be targeted to stop virus replication in cell culture using existing drugs.

21 Sep 2021

Cytotoxicity News and Research

Mtb's exotoxin secretion and trafficking mechanism revealed

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

The SARS-CoV-2 Beta variant evades Fc effector function by ancestral strain, study says

Stenoparib effectively inhibits SARS-CoV-2 variants in vitro

Cell-based viral replication system for screening of SARS-CoV-2 drugs

The role of T follicular helper cells in the humoral immune response to SARS-CoV-2

Hemin as a potential therapy for COVID-19

New system created for targeted delivery of anti-cancer drugs

Taking lessons in molecular therapeutics from earthworms to combat COVID

Study finds FDA-approved drug has potent antiviral activity against SARS-CoV-2 and variants of concern

SARS-CoV-2 cocktail with three antibodies potent in preclinical testing

New high-throughput assay could help development of anti-COVID-19 drugs

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

Antiviral activity of wheat germ Agglutinin against SARS-CoV-2

Novel Assay Platform for 3D Microfluidic Cancer Research

Scientists identify potential antibody candidate with broad-spectrum neutralizing efficacy against SARS-CoV-2 variants

Hyperbranched polylysine nanopolymer as potential broad-spectrum antiviral against SARS-CoV-2

Study shows how SARS-CoV-2 viral proteases can be targeted to stop virus replication

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