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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Phenotypic changes in monocytes from COVID-19 patients

Researchers investigate monocytes to better understand how infection with SARS-CoV-2 can cause dysfunction in these immune cells.

5 Apr 2022

Swedish HCW study shows COVID booster shots have limited effect on Omicron

Researchers examine emerging infections in healthcare workers who received the booster vaccination either with or without prior SARS-CoV-2 infection.

5 Apr 2022

HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

New clinical research shows that lamivudine, a reverse transcriptase inhibitor widely used in HIV therapy, stopped disease progression in 25% of patients with fourth-line metastatic colorectal cancer.

5 Apr 2022

Study investigates the local-mucosal susceptibility and innate immune response to Omicron compared to other variants

A recent study observed that the replication of the SARS-CoV-2 Omicron variant was restricted in human lung tissues

5 Apr 2022

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Supporting actors sometimes steal the show. In a new study published today in Cell, researchers headed by Prof. Ido Amit at the Weizmann Institute of Science have shown that supporting cells called fibroblasts, long viewed as uniform background players, are in fact extremely varied and vital.

5 Apr 2022

Recombinant fragment of the lectin-binding region of Gal-3BP stimulates the expression of IL-6 in SARS-CoV-2 sensitive cells

A recent study investigated the impact of a recombinant fragment of cellular glycoprotein Gal-3BP on IL-6 expression in acute COVID-19.

5 Apr 2022

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

A new study describes a new variant that resembles the SARS-CoV-2 Omicron BA.21 for the most part but has a small segment at the 3’ tip that belongs to the BA.1 variant.

5 Apr 2022

Study generates a picture of the myocardial transcriptional landscape of COVID-19

Researchers profiled cardiac tissue transcriptomes of COVID-19 patients.

5 Apr 2022

Prior COVID vaccination induces a more robust antibody response to Omicron

A recent study posted to the medRxiv* preprint server assessed the impact of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on the human immune response against SARS-CoV-2 Omicron infection.

5 Apr 2022

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

A recent study posted to the bioRxiv* preprint server investigated the active genetic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), its emerging mutations, and the existence of antiviral resistance against Mpro inhibitors like paxlovid.

5 Apr 2022

Air surveillance of SARS-CoV-2 and other respiratory pathogens

A recent study posted to the medRxiv* preprint server reported severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) detection in air samples from real-world congregate settings.

4 Apr 2022

Animal study provides insights into how COVID-19 can lead to long-term pain

A new animal study has provided important insights into how COVID-19 SARS-CoV-2 - the virus responsible for COVID-19 - can lead to long-term pain.

4 Apr 2022

Study suggests severe neuroinvasion by SARS-CoV-2 in individuals with alcohol use disorder

Researchers investigated the effect of repeated alcohol exposure and withdrawal on angiotensin-converting enzyme 2 and transmembrane serine protease 2 expression, putative regulators of SARS-CoV-2 entry, in discrete brain regions.

4 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

Smart toilets for passive surveillance of SARS-CoV-2

In a recent study published in Nature Digital Medicine, researchers highlighted a potential strategy for using a smart toilet platform, Coronavirus: Integrated Diagnostic (COV-ID), for passive monitoring of coronavirus disease 2019 (COVID-19).

3 Apr 2022

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or "bad" cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of heart disease risk.

3 Apr 2022

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Scientists develop a formulation for the pulmonary administration of siRNA. The aim was to suppress the replication of SARS-CoV-2.

3 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

3 Apr 2022

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

In a paper in the journal Nature, Los Alamos National Laboratory scientists Bette Korber, Hyejin Yoon, Will Fischer and James Theiler, among nearly 130 authors from institutions around the world, describe their groundbreaking collaborative work, "Defining the risk of SARS-CoV-2 variants on immune protection."

1 Apr 2022

RNA News and Research

Further Reading

Phenotypic changes in monocytes from COVID-19 patients

Swedish HCW study shows COVID booster shots have limited effect on Omicron

HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

Study investigates the local-mucosal susceptibility and innate immune response to Omicron compared to other variants

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Recombinant fragment of the lectin-binding region of Gal-3BP stimulates the expression of IL-6 in SARS-CoV-2 sensitive cells

“MixOmicron” SARS-CoV-2 recombinant evades variant screening

Study generates a picture of the myocardial transcriptional landscape of COVID-19

Prior COVID vaccination induces a more robust antibody response to Omicron

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

Air surveillance of SARS-CoV-2 and other respiratory pathogens

Animal study provides insights into how COVID-19 can lead to long-term pain

Study suggests severe neuroinvasion by SARS-CoV-2 in individuals with alcohol use disorder

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

Smart toilets for passive surveillance of SARS-CoV-2

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

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