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Study reveals acidic conditions as key to pancreatic cancer survival

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells.

9 Oct 2025

New gene therapy reverses symptoms of SYNGAP1-related disorders in mice

In an exciting scientific first, researchers at the Allen Institute successfully designed a new gene therapy that reversed symptoms related to SYNGAP1-related disorders (SRD) in mice.

9 Oct 2025

Natural sweetener improves hair loss treatment

Androgenetic alopecia is a common form of hair loss in both men and women-also called male pattern baldness and female pattern hair loss.

9 Oct 2025

Nasal spray of gold nanoparticles delivers lithium directly to the brain

In the form of a 'nasal spray', tiny gold particles act as carriers, delivering a treatment directly to the brain: developed by scientists at the Università Cattolica Rome campus/Fondazione Policlinico Universitario A. Gemelli IRCCS, a new nanotechnological device for the treatment and prevention of neuropsychiatric and neurodegenerative diseases.

8 Oct 2025

Deregulated miR-145 and miR-27b impact adipogenesis in Hutchinson-Gilford progeria syndrome

A new research paper was published in Volume 17, Issue 9 of Aging-US on August 27, 2025, titled, "Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis."

7 Oct 2025

Investigating cannabidiol's role in combating Alzheimer's-related neuroinflammation

Neuroinflammation damages neurons and can contribute to diseases like Alzheimer's. Cannabidiol (CBD) has anti-inflammatory properties, which suggests that it could combat neuroinflammation in Alzheimer's.

6 Oct 2025

Zika virus exposure during pregnancy permanently shapes offspring's frontline immune cells

A Wayne State University study published in the Oct. 3, 2025, issue of Nature Communications revealed that Zika virus exposure during pregnancy causes long-term, sex-specific changes to a baby's immune system, particularly affecting the frontline immune cells that fight infection.

6 Oct 2025

Deadly brain cancer erodes skull bone and alters immune marrow

Scientists at Montefiore Einstein Comprehensive Cancer Center (MECCC) and Albert Einstein College of Medicine have shown for the first time that glioblastoma-the deadliest form of brain cancer-affects not just the brain but also erodes the skull, alters the makeup of skull marrow, and interferes with the body's immune response.

3 Oct 2025

Study uncovers cerebellar involvement and social impairment

Spinal muscular atrophy is a rare genetic disease of the nerve cells in the spinal cord that can appear as early as infancy. The disease leads to a progressive loss of muscle strength. Those affected often suffer from muscle weakness early on, as well as difficulties with movement, breathing, and swallowing.

3 Oct 2025

Negative behavioral effects of psilocybin persist in mouse mothers and offspring

Magic mushrooms may not be the answer to postpartum depression, new research from the University of California, Davis suggests.

30 Sep 2025

Researchers design factor IX variants for short- and long-term Hemophilia B management

After blood vessel damage, effective blood clotting is essential to halt bleeding. However, this process is inefficient in some individuals due to hereditary factors. Hemophilia B, for example, results from a deficiency in coagulation factor IX (FIX), which can lead to prolonged bleeding after injuries or surgery.

30 Sep 2025

New evidence shows blood-brain barrier remains intact in Alzheimer's mouse model

A team of scientists at Texas Tech University Health Sciences Center (TTUHSC) has published new evidence suggesting that the brain's protective shield - known as the blood-brain barrier (BBB) - remains largely intact in a commonly used mouse model of Alzheimer's disease.

29 Sep 2025

Precision probiotics lower blood sugar and cholesterol in mice

Researchers developed a precision probiotic cocktail comprising three Lactobacillus strains that improved glucose control, reduced weight gain, and lowered cholesterol levels in mice fed a high-fat diet. Metabolomic and microbiome analyses revealed host metabolic adaptations and beneficial shifts in gut bacteria, highlighting translational potential for future clinical trials.

28 Sep 2025

Can roselle help fight inflammation? New review suggests strong potential

A new review highlights the anti-inflammatory potential of Hibiscus sabdariffa (roselle), synthesizing evidence from 25 studies published between 2019 and 2024. Most findings are from preclinical models, but they point to promising roles in cardiovascular, metabolic, neuroprotective, and anticancer health.

28 Sep 2025

Gut probiotic Christensenella tenuis reduces endotoxemia and improves metabolism in obese mice

This study is reported by the team of Professor Shuang-jiang Liu from Shandong University. The study reveals that the gut probiotic Christensenella tenuis significantly alleviates endotoxemia and metabolic disorders in a diet-induced obesity (DIO) mouse model by modulating gut bile acids (BAs) metabolism and suppressing lipopolysaccharide (LPS) translocation across the gut barrier.

26 Sep 2025

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson's disease. The disease presents a complex set of motor symptoms, including tremors, rigidity, bradykinesia, and postural instability.

26 Sep 2025

Calcium-induced release identified as key driver of dangerous muscle disorders

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

25 Sep 2025

Genetic modification enhances "living drugs" for blood cancers

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

25 Sep 2025

Loss of Trp53 gene affects immune responses in ovarian cancer

A new research paper was published in Volume 16 of Oncotarget on September 22, 2025, titled "Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma."

24 Sep 2025

Study provides new insights into the mechanisms of fetal membrane healing

When a pregnant woman's water breaks too early, it often leads to preterm birth, with no effective method to prevent or treat it.

23 Sep 2025

Mouse Model News and Research

Study reveals acidic conditions as key to pancreatic cancer survival

New gene therapy reverses symptoms of SYNGAP1-related disorders in mice

Natural sweetener improves hair loss treatment

Nasal spray of gold nanoparticles delivers lithium directly to the brain

Deregulated miR-145 and miR-27b impact adipogenesis in Hutchinson-Gilford progeria syndrome

Investigating cannabidiol's role in combating Alzheimer's-related neuroinflammation

Zika virus exposure during pregnancy permanently shapes offspring's frontline immune cells

Deadly brain cancer erodes skull bone and alters immune marrow

Study uncovers cerebellar involvement and social impairment

Negative behavioral effects of psilocybin persist in mouse mothers and offspring

Researchers design factor IX variants for short- and long-term Hemophilia B management

New evidence shows blood-brain barrier remains intact in Alzheimer's mouse model

Precision probiotics lower blood sugar and cholesterol in mice

Can roselle help fight inflammation? New review suggests strong potential

Gut probiotic Christensenella tenuis reduces endotoxemia and improves metabolism in obese mice

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Calcium-induced release identified as key driver of dangerous muscle disorders

Genetic modification enhances "living drugs" for blood cancers

Loss of Trp53 gene affects immune responses in ovarian cancer

Study provides new insights into the mechanisms of fetal membrane healing

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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