Preclinical News and Research

RSS

Protein-secreting device implanted in epileptic rats reduces seizures, improves cognition

A protein-secreting device implanted into the hippocampus of epileptic rats reduces seizures by 93 percent in three months, finds preclinical research published in JNeurosci.

From Society for Neuroscience 22 Jan 2019

Blood marker could aid in early prediction of Alzheimer's progression

Years before symptoms of Alzheimer's disease manifest, the brain starts changing and neurons are slowly degraded. Scientists at the German Center for Neurodegenerative Diseases, the Hertie Institute for Clinical Brain Research and the University Hospital Tuebingen now show that a protein found in the blood can be used to precisely monitor disease progression long before first clinical signs appear.

21 Jan 2019

Simple blood test reliably detects signs of Alzheimer’s damage before symptoms

A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease - even before they show signs of confusion and memory loss, according to a new study from Washington University School of Medicine in St. Louis and the German Center for Neurodegenerative Diseases in Germany.

21 Jan 2019

Blood test detects brain damage linked to Alzheimer’s years before symptoms develop

Researchers have developed a blood test that can detect signs of brain damage among people who will develop Alzheimer’s years before the onset of memory loss.

21 Jan 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

Scientists pinpoint a set of molecules that wire the body weight center of the brain

Leading a unique, collaborative research study with scientists across the globe, investigators at the University of Cambridge and Children's Hospital Los Angeles have pinpointed a set of molecules that wire the body weight center of the brain.

18 Jan 2019

Innovative ‘light’ method demonstrates positive results in fight against malignant tumors

A team of scientists from the National University of Science and Technology "MISIS", the Moscow Technological University and the Pirogov Russian National Research Medical University has experimentally proved the effectiveness of the formerly suggested "light" method in oncotherapy.

18 Jan 2019

Training Students to use Imaging Techniques: NMR and EPR

In this interview, Judy MacInnis from Cape Breton university, explains the importance of giving students hands-on EPR experience during in their studies.

From Bruker BioSpin Group 15 Jan 2019

Microbial metabolite from pomegranates can reduce and protect against IBD

Scientists at the University of Louisville have shown that a microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease.

10 Jan 2019

TARA Biosystems and Insilico Medicine collaborate to discover novel therapies for cardiac disease

TARA Biosystems, Inc. a company offering “heart-on-a-chip” tissue models for drug discovery and risk assessment applications and Insilico Medicine, an artificial intelligence company developing end-to-end drug discovery pipelines for age-related diseases, announced today the launch of a collaboration to discover and develop novel therapies for cardiac disease and diseases associated with cardiac muscle aging.

9 Jan 2019

FDA approves initiation of first-in-human trial of DNA-encoded monoclonal antibody

The Wistar Institute, along with partners Penn Medicine and Inovio Pharmaceuticals, Inc., announce that the FDA has approved the initiation of a first-in-human clinical trial investigating the safety and tolerability of a novel synthetic DNA-encoded monoclonal antibody therapeutic technology for the prevention of Zika virus infection.

9 Jan 2019

Thubrikar announces first human implant of Optimum TAV using their TAVI system

Thubrikar Aortic Valve, Inc., a privately held medical device company, today announced the first human implant of the Optimum TAV using their transcatheter aortic valve implantation system.

9 Jan 2019

Exposure to cannabis, stress during adolescence may lead to long-term anxiety disorders

A new study conducted on laboratory animals shows that exposure to cannabis and stress during adolescence may lead to long-term anxiety disorders characterized by the presence of pathological fear.

8 Jan 2019

New anti-Wolbachia drug could potentially treat onchocerciasis and lymphatic filariasis

Researchers from LSTM and the University of Liverpool have successfully optimized a hit from a whole cell screening of a 10000-compound library to deliver the first novel fully synthetic and rationally designed anti-Wolbachia drug, AWZ1066S, which could potentially be used to treat onchocerciasis and lymphatic filariasis.

8 Jan 2019

Insilico Medicine and TARA Biosystems collaborate to develop novel therapies for cardiac diseases

Insilico Medicine, an artificial intelligence company developing end-to-end drug discovery pipelines for age-related diseases and TARA Biosystems, Inc. a company offering "heart-on-a-chip" tissue models for drug discovery and risk assessment applications, announced today the launch of a collaboration to discover and develop novel therapies for cardiac disease and diseases associated with cardiac muscle aging.

8 Jan 2019

Therapeutic implications of caffeine in neuropsychiatric disorders

An important new article reviews recently discovered properties of adenosine A2A receptor-dopamine D2 receptor and adenosine A1 receptor-dopamine D1 receptor heteromers--both of which are main targets for caffeine--and discusses the therapeutic implications of these findings.

7 Jan 2019

New medications provide better treatment for alcohol use disorders, chronic pain, mood disorders

Helping people with addictions has become a research passion for Purdue University's Richard van Rijn, who is leading a team to make drug discoveries to support millions around the world dealing with alcohol use disorders, chronic pain and mood disorders.

3 Jan 2019

Envigo expands its bioanalytical capabilities in response to increased market demand

Envigo, a leading provider of nonclinical contract research services and research models, has invested in an expansion of its global bioanalytical capabilities in response to increased market demand from its biopharmaceutical customers.

From Inotiv, Inc. 3 Jan 2019

Treatment of age-related hearing loss could be one way to head off late-life depression

A new study found that elderly individuals with age-related hearing loss had more symptoms of depression; the greater the hearing loss, the greater the risk of having depressive symptoms.

3 Jan 2019

Hyperactive immune system implicated in aging brain disorders

In a study of fruit flies, NIH scientists suggested that the body's immune system may play a critical role in the damage caused by aging brain disorders. The results are based on experiments in which the researchers altered the activity of Cdk5, a gene that preclinical studies have suggested is important for early brain development and may be involved in neurodegenerative diseases, such as ALS, Alzheimer's and Parkinson's disease.

2 Jan 2019

Preclinical News and Research

Protein-secreting device implanted in epileptic rats reduces seizures, improves cognition

Blood marker could aid in early prediction of Alzheimer's progression

Simple blood test reliably detects signs of Alzheimer’s damage before symptoms

Blood test detects brain damage linked to Alzheimer’s years before symptoms develop

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Scientists pinpoint a set of molecules that wire the body weight center of the brain

Innovative ‘light’ method demonstrates positive results in fight against malignant tumors

Training Students to use Imaging Techniques: NMR and EPR

Microbial metabolite from pomegranates can reduce and protect against IBD

TARA Biosystems and Insilico Medicine collaborate to discover novel therapies for cardiac disease

FDA approves initiation of first-in-human trial of DNA-encoded monoclonal antibody

Thubrikar announces first human implant of Optimum TAV using their TAVI system

Exposure to cannabis, stress during adolescence may lead to long-term anxiety disorders

New anti-Wolbachia drug could potentially treat onchocerciasis and lymphatic filariasis

Insilico Medicine and TARA Biosystems collaborate to develop novel therapies for cardiac diseases

Therapeutic implications of caffeine in neuropsychiatric disorders

New medications provide better treatment for alcohol use disorders, chronic pain, mood disorders

Envigo expands its bioanalytical capabilities in response to increased market demand

Treatment of age-related hearing loss could be one way to head off late-life depression

Hyperactive immune system implicated in aging brain disorders

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics