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About 60 percent of SARS-CoV-2 cases in England tied to new variant by the end of December

One new SARS-CoV-2 variant of concern, called 202012/01, started to spread in England in late October. A new study published on the pre-print server medRxiv found that 60 percent of daily COVID-19 cases screened by the Alderley Park Lighthouse Labs were tied to 202012/01, also known as lineage B.1.1.7 or 20B/501Y.V1. This suggests a rapid spread of the new variant across the country.

18 Jan 2021

Using 'federated learning' to enhance predictions of COVID-19 outcomes

Mount Sinai researchers have published one of the first studies using a machine learning technique called "federated learning" to examine electronic health records to better predict how COVID-19 patients will progress.

18 Jan 2021

New SARS-CoV-2 variant emerges in the U.S.

Even as the rollout of vaccines all over the world brings a glimmer of hope that the current coronavirus disease 2019 (COVID-19) pandemic may end in the near future, new variants continue to emerge, some with the potential to escape vaccine-induced or therapeutic antibodies. Now, a new preprint research paper published on the bioRxiv server describes a new American variant that may have become the dominant strain in the USA.

18 Jan 2021

SARS-CoV-2 anti-N rigid monoclonal antibodies provide accurate early diagnosis

An interesting new preprint research paper that was posted on the bioRxiv* server recently describes the use of rigid monoclonal antibodies (mAbs) in contrast to flexible mAbs, and how this affects the binding of multiple mAbs to the same antigen.

17 Jan 2021

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Researchers in Saudi Arabia have conducted a study demonstrating the antiviral effects of two medicinal herbs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

17 Jan 2021

Study: NTRK fusions are far more frequently seen in pediatric tumors

In a large study of pediatric cancer patients, researchers from Children's Hospital of Philadelphia have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors.

16 Jan 2021

New tests may help improve the selection of men considering prostate cancer surveillance

Sylvester Comprehensive Cancer Center researchers are looking at ways to combine imaging and biomarkers to predict prostate cancer progression more accurately.

15 Jan 2021

White-tailed deer susceptible to SARS-CoV-2 infection, study finds

A team of scientists recently demonstrated that white-tailed deer are highly susceptible to SARS-CoV-2 infection. Moreover, the infected animals are capable of transmitting the virus to their non-infected counterparts via indirect contact.

15 Jan 2021

Image-based deep learning haplotype-guided study maps the global adaptation of SARS-CoV-2

A new study used deep learning with image recognition technology to trace the emergence of variants with increased viral fitness. Higher fitness leads to rapid expansion of these lineages in the areas where they are introduced. This type of study could facilitate the development of more effective antibodies and vaccines to help contain the pandemic.

15 Jan 2021

Concern develops over Brazilian SARS-CoV-2 variant

Concern is being expressed over a variant of SARS-CoV-2 that shows similar mutations to the South African and UK variants of the disease.

15 Jan 2021

Researchers use deep learning to study the effect of mental illness and other disorders on the brain

Compared to standard machine learning models, deep learning models are largely superior at discerning patterns and discriminative features in brain imaging, despite being more complex in their architecture, according to a new study in Nature Communications led by Georgia State University.

15 Jan 2021

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

It was also classified as a "Variant of Concern" (VOC B.1.1.7) in December 2020. First discovered in Kent, United Kingdom, in September 2020, this new variant has since been found in more than 29 countries across the globe, including the USA.

14 Jan 2021

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

As the COVID-19 pandemic continues to infect people in their hundreds of thousands around the world, a new study describes a panel of novel tests for genomic (g) and subgenomic (sg) mRNAs generated by SARS-CoV-2. Most assays in use at present are either qualitative or semi-quantitative, and cannot evaluate the transcription molecules in detail.

14 Jan 2021

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages.

14 Jan 2021

New deep-learning framework predicts gene regulation at single-cell level

Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level.

13 Jan 2021

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers from Boston University School of Medicine provide a new genomics resource that details the small RNA transcriptomes (gene expression) of four bio-medically important mosquito species.

13 Jan 2021

New N501 SARS-CoV-2 mutation may have been circulating in Italy since August 2020

A recent study shows that mutated SARS-CoV-2 strains with a substitution at position 501 might have circulated unnoticed even before the end of September 2020, when the rapid emergence of B.1.1.7 lineage (carrying the N501Y mutation) was initially reported.

13 Jan 2021

Genomic News and Research

About 60 percent of SARS-CoV-2 cases in England tied to new variant by the end of December

Using 'federated learning' to enhance predictions of COVID-19 outcomes

New SARS-CoV-2 variant emerges in the U.S.

SARS-CoV-2 anti-N rigid monoclonal antibodies provide accurate early diagnosis

Research suggests St. John's Wort and Echinacea could protect against COVID-19

Study: NTRK fusions are far more frequently seen in pediatric tumors

New tests may help improve the selection of men considering prostate cancer surveillance

White-tailed deer susceptible to SARS-CoV-2 infection, study finds

Image-based deep learning haplotype-guided study maps the global adaptation of SARS-CoV-2

Concern develops over Brazilian SARS-CoV-2 variant

Researchers use deep learning to study the effect of mental illness and other disorders on the brain

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests

New deep-learning framework predicts gene regulation at single-cell level

New genomics resource details the small RNA transcriptomes of four mosquito species

New N501 SARS-CoV-2 mutation may have been circulating in Italy since August 2020

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Large study provides new understanding of genome diversity in Ukrainian population

Recurring glioblastomas with very few mutations are far more vulnerable to immunotherapies

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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