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Innovative implant material combines bone regeneration and infection control

A research team from Shanghai Jiao Tong University has resulted in a significant advancement in the field of orthopedic implant materials.

6 Aug 2025

Flavonols found in foods can block drug resistance protein and boost medication absorption

Researchers identified specific flavonols that potently inhibit breast cancer resistance protein (BCRP), a key driver of drug resistance and poor oral drug absorption. The study found that these flavonols can reverse chemotherapy resistance in vitro and boost drug exposure in animal models, though clinical translation remains uncertain.

6 Aug 2025

Starfish compound overcomes drug resistance in prostate cancer models

Researchers identified that triterpene glycosides from the starfish Solaster pacificus can kill drug-resistant prostate cancer cells in vitro by bypassing common resistance pathways. CuC1 showed synergy with existing chemotherapies, though with only moderate selectivity for cancer cells.

5 Aug 2025

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.

5 Aug 2025

Characterization of antibodies targeting ASO modifications for intracellular trafficking

A new article in the peer-reviewed journal Nucleic Acid Therapeutics describes the characterization of antibodies targeting antisense oligonucleotide (ASO) phosphorothioate and 2'-methoxyehtyl modifications for intracellular trafficking and biodistribution studies.

1 Aug 2025

New radioimmunotherapy approach eliminates cancer stem cells in preclinical models of ovarian cancer

A new radioimmunotherapy approach has been shown to successfully eliminate cancer stem cells (CSCs) in preclinical models of ovarian cancer, outperforming the current gold standard.

1 Aug 2025

AI-designed protein activates Notch signaling pathway to boost T-cell production

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.

1 Aug 2025

Powerful bioactives found in overlooked Amazonian fruits

Lesser-known Amazonian fruits exhibit strong antioxidant and antimicrobial properties, highlighting their role in public health and biotechnology research.

31 Jul 2025

AI uncovers new lipid-lowering effects in existing FDA-approved drugs

In a breakthrough for cardiovascular medicine, researchers have harnessed artificial intelligence to discover unexpected lipid-lowering effects in existing FDA-approved drugs.

31 Jul 2025

NKAPL identified as a tumor suppressor and therapeutic target in NSCLC

Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases and is often diagnosed at advanced stages, limiting treatment options.

29 Jul 2025

Plant compounds show promise against leishmaniasis through mitochondrial targeting

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, affects millions globally. Current synthetic treatments face limitations including toxicity, cost, and resistance.

28 Jul 2025

Restoring mitochondria enhances immune response against lung cancer

While chemotherapy remains a cornerstone of lung cancer treatment, it often weakens the immune system it relies on for long-term control.

28 Jul 2025

Australian scientists uncover new way to halt aggressive cancer growth

Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat cancers by targeting a specialized molecular process known as 'minor splicing'.

28 Jul 2025

New swallowable sensor pill reveals gut inflammation with a simple color change

Researchers have developed an ingestible biosensor pill (PRIM) that detects intestinal inflammation by releasing a blue dye in response to elevated reactive oxygen species, providing a simple, at-home visual indicator.

27 Jul 2025

In-depth look at breast tumor growth and surgical delay effects

Using a novel method to analyze tumor growth rates, researchers at Fox Chase Cancer Center have provided the most in-depth assessment to date of how fast breast cancers grow in patients and how surgical delays may affect breast cancer staging, which measures the extent of cancer spread in the body. The newly published study offers new insight into how tumors progress in the time between diagnosis and surgery.

25 Jul 2025

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress.

24 Jul 2025

Probiotic bacteria found to reshape cell behavior in vitro

This study reveals how probiotic bacteria directly influence brain cell function, highlighting gut-brain communication and potential therapeutic applications.

23 Jul 2025

New approach doubles chemotherapy effectiveness by targeting cancer cell memory

In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments.

22 Jul 2025

New imaging technique reveals how cells organize glucose processing

In a scientific first, researchers from Vanderbilt University and the University of California, San Diego, have generated a high-resolution metabolic "map" of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients.

22 Jul 2025

Uranium isotope in urine identified as early warning sign of kidney damage

A new study by researchers at Columbia University Mailman School of Public Health identified that uranium's isotopic composition can be used as a biomarker to noninvasively measure accumulation of uranium in the kidneys.

22 Jul 2025

in vivo News and Research

Innovative implant material combines bone regeneration and infection control

Flavonols found in foods can block drug resistance protein and boost medication absorption

Starfish compound overcomes drug resistance in prostate cancer models

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

Characterization of antibodies targeting ASO modifications for intracellular trafficking

New radioimmunotherapy approach eliminates cancer stem cells in preclinical models of ovarian cancer

AI-designed protein activates Notch signaling pathway to boost T-cell production

Powerful bioactives found in overlooked Amazonian fruits

AI uncovers new lipid-lowering effects in existing FDA-approved drugs

NKAPL identified as a tumor suppressor and therapeutic target in NSCLC

Plant compounds show promise against leishmaniasis through mitochondrial targeting

Restoring mitochondria enhances immune response against lung cancer

Australian scientists uncover new way to halt aggressive cancer growth

New swallowable sensor pill reveals gut inflammation with a simple color change

In-depth look at breast tumor growth and surgical delay effects

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

Probiotic bacteria found to reshape cell behavior in vitro

New approach doubles chemotherapy effectiveness by targeting cancer cell memory

New imaging technique reveals how cells organize glucose processing

Uranium isotope in urine identified as early warning sign of kidney damage

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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