Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Modeling Alzheimer’s Disease Using Microfluidics

An interview with Dr. Joseph Park, the incorporation of astrocytes into the Alzheimer’s-in-a-dish culture system and it's applications in drug development.

24 Oct 2018

New study finds evidence that animals can judge time

Are you taking your time when feeding your pet? Fluffy and Fido are on to you -- and they can tell when you are dawdling.

24 Oct 2018

Novartis: Lancet publishes pioneering study of Aimovig’s efficacy in episodic migraine patients

Novartis announced today that the full data from the LIBERTY study of Aimovig (erenumab) in episodic migraine patients who had tried and failed two to four prior preventive treatments have been published in the Lancet.

23 Oct 2018

Drug cocktail that increases lifespan discovered

A team of researchers led by Principal Investigator Dr Jan Gruber from Yale-NUS College has discovered a combination of pharmaceutical drugs that not only increases healthy lifespan in the microscopic worm Caenorhabditis elegans (C. elegans), but also delays the rate of ageing in them, a finding that could someday mean longer, healthier lives for humans.

22 Oct 2018

Epigenetic modifications may contribute to Alzheimer's Disease

Scientists report epigenetic modifications in the brains of patients with Alzheimer's, after observing differences in histone acetylation across the genome.

22 Oct 2018

New protein sequencing technique could revolutionize biomedical research

Scientists have developed a new, low-throughput technique that allows individual proteins to be identified. It is called single molecule fluorosequencing.

22 Oct 2018

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING (stimulator of interferon genes) agonist, as monotherapy and in combination with KEYTRUDA (pembrolizumab), Merck's anti-PD-1 therapy, in patients with advanced solid tumors or lymphomas.

22 Oct 2018

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

Merck, known as MSD outside the United States and Canada, today announced the first presentation of results from an interim analysis of KEYNOTE-057, a Phase 2 trial evaluating KEYTRUDA, Merck's anti-PD-1 therapy, for previously treated patients with high-risk non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ or CIS plus papillary disease (Cohort A).

22 Oct 2018

ApoE4 gene linked with chronic inflammation increases risk for Alzheimer's disease

While it is widely shown that possessing the ApoE4 gene is the major genetic risk factor of Alzheimer's disease, not all ApoE4 carriers develop AD.

20 Oct 2018

Could we prevent Alzheimer's disease by treating herpes?

An exciting new paper suggests that over half of all cases of Alzheimer’s disease could be traced back to herpes simplex virus 1, which causes cold sores.

19 Oct 2018

Newly discovered compound shows potential for treating Parkinson's disease

A joint research group centered around Professor Hideyuki Okano and Associate Professor Jun Kohyama, Department of Physiology of the Keio University School of Medicine, together with a research group of Eisai Co., Ltd. has identified a compound that has the potential to be a treatment for Parkinson's disease by using dopaminergic neurons differentiated from induced pluripotent stem (iPS) cells from patients with familial Parkinson's disease.

19 Oct 2018

University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia

The National Science Foundation awarded $1,182,305 to the University of Pittsburgh Swanson School of Engineering to support research into using machine learning and Big Data to analyze electronic anesthesia records and prevent postoperative complications and death.

19 Oct 2018

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

A group of Massachusetts General Hospital investigators is proposing that targeting immune checkpoints - molecules that regulate the activity of the immune system - in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

17 Oct 2018

Down syndrome may hold important clues to onset of Alzheimer's disease

At first glance, Down syndrome and Alzheimer's disease, two severe brain abnormalities, may seem to have little in common. Down syndrome is a hereditary disease, the source of which has long been recognized--a triplication of chromosome 21.

17 Oct 2018

New research identifies modifiable dementia risk factor in elderly people

For older adults, it may seem as though the die is already cast regarding their odds of developing dementia, but new research from the University of Pittsburgh has identified a dementia risk factor among older adults that should be modifiable even well into old age.

16 Oct 2018

Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration

Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier--which keeps large molecules in the blood from entering the brain--becomes abnormally permeable, allowing fibrin to leak into the brain and trigger inflammation.

16 Oct 2018

Neuropsychiatric symptoms related to earliest stages of Alzheimer's brain pathology

UC San Francisco researchers, in collaboration with the unique Brazilian Biobank for Aging Studies at the University of São Paulo, have shown that the earliest stages of the brain degeneration associated with Alzheimer's disease are linked to neuropsychiatric symptoms including anxiety, depression, loss of appetite, and sleep disturbances.

15 Oct 2018

Alzheimer's Disease News and Research

Further Reading

Modeling Alzheimer’s Disease Using Microfluidics

New study finds evidence that animals can judge time

Novartis: Lancet publishes pioneering study of Aimovig’s efficacy in episodic migraine patients

Drug cocktail that increases lifespan discovered

Epigenetic modifications may contribute to Alzheimer's Disease

New protein sequencing technique could revolutionize biomedical research

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck presents KEYNOTE-057 trial results for patients with high-risk non-muscle invasive bladder cancer

ApoE4 gene linked with chronic inflammation increases risk for Alzheimer's disease

Could we prevent Alzheimer's disease by treating herpes?

Newly discovered compound shows potential for treating Parkinson's disease

University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Down syndrome may hold important clues to onset of Alzheimer's disease

New research identifies modifiable dementia risk factor in elderly people

Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration

Neuropsychiatric symptoms related to earliest stages of Alzheimer's brain pathology

Vast majority of dementia cases may arise from spontaneous genetic errors

Study reveals potential to monitor progression of Alzheimer’s disease by measuring brain antioxidant levels

Brain oscillations provide insights into the human navigation system

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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