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Vanderbilt researchers illuminate white matter signals in the spinal cord

Injuries, infection and inflammatory diseases that damage the spinal cord can lead to intractable pain and disability. Some degree of recovery may be possible. The question is, how best to stimulate the regrowth and healing of damaged nerves.

2 Aug 2024

Pioneering study brings leishmaniasis vaccine development closer

Scientists have developed a new, safe and effective way to infect volunteers with the parasite that causes leishmaniasis and measure the body's immune response, bringing a vaccine for the neglected tropical disease a step closer.

2 Aug 2024

How machine learning is accelerating research in structural biology

For Lucas Farnung, there is no question more fascinating than how a single fertilized egg develops into a fully-functioning human.

2 Aug 2024

Decreasing folate intake can support healthier metabolisms in aging animal models

In a study published in Life Science Alliance, Texas A&M AgriLife Research scientists found that decreasing folate intake can support healthier metabolisms in aging animal models, challenging the conventional belief that high folate consumption universally benefits health.

2 Aug 2024

Public insurance recipients less likely to receive diabetes and obesity drug, study reveals

A new USC study suggests that publicly insured individuals who are most likely to benefit from new drugs for diabetes and obesity are less likely to get them than those with private insurance.

2 Aug 2024

FDA grants accelerated approval for first engineered T cell therapy to treat adults with synovial sarcoma

The U.S. Food and Drug Administration (FDA) has granted accelerated approval for the immunotherapy afamitresgene autoleuecel (Tecelra®, also known as afami-cel) for the treatment of adults with a rare soft tissue cancer called synovial sarcoma.

2 Aug 2024

Since fall of ‘Roe,’ self-managed abortions have increased

The percentage of people who say they've tried to end a pregnancy without medical assistance increased after the Supreme Court overturned Roe v. Wade.

2 Aug 2024

Uncovering hidden drug benefits through protein mapping

Fewer side effects, improved chances of healing: the goal of precision medicine is to provide patients with the most individualized treatment possible. This requires a precise understanding of what is happening at the cellular level. For the first time, researchers at the Technical University of Munich (TUM) have now succeeded in mapping the interactions of 144 active substances with around 8,000 proteins. The results could help to identify previously unknown potential benefits of existing drugs.

2 Aug 2024

Researchers identify strategy to design safer opioids

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

2 Aug 2024

Triptolide-based treatment prolongs symptom-free survival in preclinical medulloblastoma models

A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models – all without showing signs of toxicity.

1 Aug 2024

How states pioneered the medical marijuana movement in America

From the war on drugs to the current wave of legalization efforts, public opinion in the United States has shifted on few issues like it has with marijuana.

1 Aug 2024

Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

In a groundbreaking study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

1 Aug 2024

Uncontrolled hypertension: A persistent threat to global health

In the United States and worldwide, cardiovascular disease is the leading avoidable cause of premature death and disability. Primarily heart attacks and stroke, cardiovascular disease accounts for more than 900,000 annual deaths nationally and about 10 million deaths globally.

1 Aug 2024

$Study reveals obesity's impact on muscle structure in heart failure with preserved ejection fraction$

Study reveals obesity's impact on muscle structure in heart failure with preserved ejection fraction

A new small study led by Johns Hopkins Medicine researchers and published July 25th in the journal Nature Cardiovascular Research has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF).

1 Aug 2024

New lab technique captures aging effects in Alzheimer's disease development

Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer's disease.

1 Aug 2024

Novel electrical impedance technique enhances drug testing for cardiac safety

When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical.

1 Aug 2024

Study reveals how geographic origins influence tuberculosis infection risk

For some forms of tuberculosis, the chances that an exposed person will get infected depend on whether the individual and the bacteria share a hometown, according to a new study comparing how different strains move through mixed populations in cosmopolitan cities.

1 Aug 2024

Targeting 14 modifiable risk factors from childhood to old age could prevent or delay dementia

Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, even as people around the world live longer and the number of people with dementia is set to rise dramatically in all countries, according to the third Lancet Commission on dementia prevention, intervention, and care, which is being presented at the Alzheimer's Association International Conference (AAIC 2024).

1 Aug 2024

Novel anti-tuberculosis compound targets bacterial membrane protein

Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Duisburg-Essen (UDE) have together succeeded in identifying and synthesizing a group of molecules that can act against the cause of tuberculosis in a new way. In the scientific journal Cell Chemical Biology, they describe that the so-called callyaerins act against the infectious disease by employing a fundamentally different mechanism compared to antibiotic agents used to date.

1 Aug 2024

Scientists capture NMDAR protein's 'twist' motion, key to brain signaling

Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These bindings control NMDAR's dance steps. When their routine is over, the NMDAR opens. This open ion channel generates electrical signals critical for cognitive functions like memory.

1 Aug 2024