Preclinical News and Research

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Scientists discover new kind of small-cell lung cancer

Researchers have discovered a new kind of small-cell lung cancer. The discovery paves the way for developing personalized medicine approaches to target this previously unnoticed form of the disease.

26 Jun 2018

Study suggests new approach for treating alcohol use disorder

Activation of a receptor with no known function in the brain reduces excessive alcohol use and the pain of withdrawal, according to preclinical research in male rats. The study, published in eNeuro, suggests a new approach towards the treatment of alcohol use disorder.

26 Jun 2018

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

AbbVie , a research-based global biopharmaceutical company, and Calibr, a nonprofit drug discovery division of Scripps Research, today announced a collaboration to develop T-cell therapies aimed primarily at cancer, including solid tumors.

25 Jun 2018

Interactive preclinical PET-MR workshop demonstrates benefits of multi-modality imaging

An interactive preclinical PET-MR workshop with demonstrations of a new 7T integrated PET-MR multi-modality imaging system from MR Solutions and presentations from participants was held in Dijon last week.

From MR Solutions 21 Jun 2018

Study: Oxidative stress can be used against tumors to treat cancer

Oxidative stress can help tumors thrive, but one way novel cancer treatments work is by pushing levels to the point where it instead helps them die, scientists report.

21 Jun 2018

Review: Stem cells appear to help fight obesity in animal models

Obesity is an increasing global health problem associated with several comorbidities and a high risk of mortality.

21 Jun 2018

New therapeutic approach may delay neurodegeneration in rare genetic disease

A new therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB. Neurodegeneration in this condition results from the abnormal accumulation of essential cellular molecules called mucopolysaccharides.

21 Jun 2018

Researchers employ nucleotide-based gene silencing to mitigate common ataxia

In what researchers are calling a game changer for future ataxia treatments, a new study showed the ability to turn down the disease progression of the most common dominantly inherited ataxia.

20 Jun 2018

LabConnect collaborates with Symphony to support clinical research industry

LabConnect, LLC, a leading global provider of central laboratory and support services for biopharmaceutical, medical device and contract research organizations, and Symphony Clinical Research, a worldwide, innovative in-home clinical service provider, today announced a strategic collaboration.

20 Jun 2018

FDA provides guidance on Novus Therapeutics’ development path for OP-02 to treat otitis media

Novus Therapeutics, Inc., a specialty pharmaceutical company focused on developing products for patients with disorders of the ear, nose, and throat, announced receipt of final meeting minutes from the U.S. Food and Drug Administration following a Type C meeting held at the Company's request to discuss its OP-02 development program in otitis media.

19 Jun 2018

Can-Fite provides update on Phase II clinical trial with drug candidate Namodenoson

Can-Fite BioPharma Ltd., a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, today provided an update on its Phase II clinical trial with drug candidate Namodenoson in the treatment of advanced hepatocellular carcinoma in patients whose disease has progressed on sorafenib therapy.

19 Jun 2018

Researchers examine risk factors for opioid dependence in patients undergoing surgery for DS

Researchers investigated risk factors for the development of opioid dependence in patients undergoing surgery for degenerative spondylolisthesis

19 Jun 2018

Microglia play protective role in response to retinal detachment, shows study

A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the brain and retina, play a protective role in response to retinal detachment.

19 Jun 2018

Scientists develop novel computational framework to support personalized cancer treatment

Researchers at Columbia University Irving Medical Center have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them.

19 Jun 2018

Study finds more information about how gene linked to ASD affects the brain

New preclinical research shows a gene already linked to a subset of people with autism spectrum disorder is critical to healthy neuronal connections in the developing brain, and its loss can harm those connections to help fuel the complex developmental condition.

18 Jun 2018

Drug used to treat myelofibrosis can awaken ‘dormant’ lymphomas in the bone marrow

Most patients with myelofibrosis, a rare chronic disorder of the haematopoietic cells of the bone marrow, benefit from drugs from the JAK2 inhibitor class: symptoms are relieved, survival extended and general quality-of-life enhanced.

18 Jun 2018

NIAID launches clinical trial of investigational RSV vaccine

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a clinical trial of an investigational vaccine designed to protect against respiratory syncytial virus.

14 Jun 2018

MR Solutions offers upgrade service for old MRI scanners to provide advanced imaging quality

Following requests from customers MR Solutions is now offering a service to upgrade old MRI scanners to provide state of the art imaging quality. The key technology in an MRI scanner is the spectrometer or “electronic brains” which interprets the signals from the magnet and creates the image.

From MR Solutions 14 Jun 2018

Genetically engineered bacteria shows promise as new treatment for constipation

Genetically engineered bacteria are showing promise as a new treatment for constipation, researchers at the Mayo Clinic Center for Individualized Medicine have discovered in a mouse study.

14 Jun 2018

Study opens new potential avenue for treating ovarian cancer

Researchers at Houston Methodist Research Institute and The University of Texas MD Anderson Cancer Center have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer.

14 Jun 2018

Preclinical News and Research

Scientists discover new kind of small-cell lung cancer

Study suggests new approach for treating alcohol use disorder

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

Interactive preclinical PET-MR workshop demonstrates benefits of multi-modality imaging

Study: Oxidative stress can be used against tumors to treat cancer

Review: Stem cells appear to help fight obesity in animal models

New therapeutic approach may delay neurodegeneration in rare genetic disease

Researchers employ nucleotide-based gene silencing to mitigate common ataxia

LabConnect collaborates with Symphony to support clinical research industry

FDA provides guidance on Novus Therapeutics’ development path for OP-02 to treat otitis media

Can-Fite provides update on Phase II clinical trial with drug candidate Namodenoson

Researchers examine risk factors for opioid dependence in patients undergoing surgery for DS

Microglia play protective role in response to retinal detachment, shows study

Scientists develop novel computational framework to support personalized cancer treatment

Study finds more information about how gene linked to ASD affects the brain

Drug used to treat myelofibrosis can awaken ‘dormant’ lymphomas in the bone marrow

NIAID launches clinical trial of investigational RSV vaccine

MR Solutions offers upgrade service for old MRI scanners to provide advanced imaging quality

Genetically engineered bacteria shows promise as new treatment for constipation

Study opens new potential avenue for treating ovarian cancer

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