Kidney News and Research

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New lipid derivatives of Remdesivir have higher anti-coronavirus activity

In a fascinating new preprint paper published on bioRxiv* in August 2020, the researchers report “the synthesis and antiviral evaluation of three novel lipophilic prodrugs of RVn-monophosphate that are substantially more active than Remdesivir in cells infected with SARS-CoV-2.” These could be of immense use in treating COVID-19 patients early and helping to end transmission.

30 Aug 2020

CNOT3 protein plays a key role in diabetes

A protein that's common throughout the body plays a key role in regulating glucose levels, says new research conducted in the Cell Signal Unit at the Okinawa Institute of Science and Technology Graduate University and Riken Center of Integrative Medical Sciences.

28 Aug 2020

Manipulating 3D Printed Organoid Microenvironments

Organoids are 3-dimensional (3D) clusters of stem cells that come together and emulate the microenvironment within individual organs, whether that be liver, kidney, heart, gut or other specific organs.

From Manchester BIOGEL 28 Aug 2020

Blood thinners help reduce the risk of COVID-19 deaths, study finds

Now, a new study by a team of researchers at the Mount Sinai Health System in New York has shown that blood thinners may reduce the risk of death by up to 50 percent among severely ill hospitalized COVID-19 patients.

27 Aug 2020

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

In a recent bioRxiv* preprint paper, researchers from the United States demonstrate the pivotal role the furin cleavage site insertion in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein plays in viral replication and pathogenesis – highlighting, in turn, the need for mutation monitoring when developing therapeutics and vaccines.

27 Aug 2020

Researchers find link between dystrophic muscles and lymphatic system in mice with Duchenne disease

Researchers at the Universities of Maynooth and Bonn discover a new connection in muscular dystrophy Duchenne muscular dystrophy (DMD) is the most common muscle disease in children and is passed on by X-linked recessive inheritance.

27 Aug 2020

Artificial pancreas manages blood sugar levels in type 1 diabetes children

An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology safely and effectively manages blood sugar levels in children ages 6 to 13 with type 1 diabetes, a national clinical trial has found.

27 Aug 2020

Scientists discover possible biomarkers for detecting opioid use disorder during pregnancy

Scientists at the University of Missouri have discovered possible biological markers that they hope could one day help identify the presence of an opioid use disorder during human pregnancy.

26 Aug 2020

Study reveals a troubling connection between coronavirus and obesity

A review of COVID-19 studies reveals a troubling connection between two health crises: coronavirus and obesity.

26 Aug 2020

Estradiol appears to help in female SARS-CoV-2 infection

A new study published on the preprint server medRxiv in August 2020 shows that the risk of infection is high for pre-menopausal women but the risk of death is much higher for men in the same age group and throws light on the protective nature of estradiol therapy in post-menopausal women.

26 Aug 2020

Dartmouth receives $2.5 million to develop device for detecting tumor left behind during surgery

Dartmouth engineers have been awarded a $2.5 million grant from the National Cancer Institute, part of the National Institutes of Health, to develop and test a device--a microendoscopic electrical impedance sensing probe-- that could be used by surgeons to detect prostate cancer still left in the body during surgery.

25 Aug 2020

Dialysis patients have higher risk for SARS-CoV-2 infection, study suggests

It's widely known that the causative agent for COVID-19, the SARS-CoV-2 virus, can spread rapidly among residents in nursing homes and other long-term care facilities, leading to high numbers of cases and deaths in a very vulnerable population.

25 Aug 2020

Study reveals protective potential of all three major immunoglobulin isotypes against SARS-CoV-2

In a recent medRxiv preprint paper, researchers from Mount Sinai in New York showed that all three major immunoglobulin isotypes (IgM, IgG, and IgA) produced by our immune cells were capable of mediating neutralization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, neutralization titers correlated much better with binding levels of IgM and IgA1 than IgG.

24 Aug 2020

Large animals with ailing livers can grow new organ in lymph nodes from their own hepatocytes

Hepatocytes -- the chief functional cells of the liver -- are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply.

24 Aug 2020

Antihypertensives improve COVID-19 survival rates

Previous studies have also linked hypertension to severe coronavirus disease (COVID-19). Now, a new study by researchers at the University of East Anglia's Norwich Medical School has found that the risk of severe COVID-19 and death was reduced for patients with high blood pressure who were taking Angiotensin-Converting Enzyme inhibitors (ACEi) or Angiotensin Receptor Blockers (ARB).

24 Aug 2020

No evidence pregnancy increases the risk of COVID-19 morbidity or severity

Albeit pregnancy is generally considered a significant risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and more severe coronavirus disease (COVID-19) outcomes, a recent study by a multinational team of researchers shows that symptoms are generally comparable between pregnant and non-pregnant cohorts of women – with the exception of gastrointestinal symptoms. This paper is currently available on the medRxiv* preprint server.

23 Aug 2020

Study highlights the need to standardize training around evaluating urine sediment tests

A new study shows that nephrologists do not always agree on their interpretation of images from urine sediment tests, which are frequently ordered to evaluate a variety of kidney diseases.

21 Aug 2020

VUMC receives $34 million grant for nationwide convalescent plasma study

Vanderbilt University Medical Center has been awarded a one-year, $34-million grant by the National Center for Advancing Translational Sciences, part of the National Institutes of Health, to conduct a nationwide study of "convalescent plasma" as a treatment for COVID-19.

21 Aug 2020

Researchers reproduce the pathogenesis of hereditary kidney disease from human iPS cells

Joint research, led by Kumamoto University in Japan, has successfully reproduced the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) from human iPS cells in vitro.

21 Aug 2020

Study could reveal brain cells and circuits that influence human health and metabolism in response to dietary changes

A new federally funded study could reveal the nervous system cells and circuits in our brains that influence our metabolism and health in response to dietary changes.

21 Aug 2020

Kidney News and Research

New lipid derivatives of Remdesivir have higher anti-coronavirus activity

CNOT3 protein plays a key role in diabetes

Manipulating 3D Printed Organoid Microenvironments

Blood thinners help reduce the risk of COVID-19 deaths, study finds

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

Researchers find link between dystrophic muscles and lymphatic system in mice with Duchenne disease

Artificial pancreas manages blood sugar levels in type 1 diabetes children

Scientists discover possible biomarkers for detecting opioid use disorder during pregnancy

Study reveals a troubling connection between coronavirus and obesity

Estradiol appears to help in female SARS-CoV-2 infection

Dartmouth receives $2.5 million to develop device for detecting tumor left behind during surgery

Dialysis patients have higher risk for SARS-CoV-2 infection, study suggests

Study reveals protective potential of all three major immunoglobulin isotypes against SARS-CoV-2

Large animals with ailing livers can grow new organ in lymph nodes from their own hepatocytes

Antihypertensives improve COVID-19 survival rates

No evidence pregnancy increases the risk of COVID-19 morbidity or severity

Study highlights the need to standardize training around evaluating urine sediment tests

VUMC receives $34 million grant for nationwide convalescent plasma study

Researchers reproduce the pathogenesis of hereditary kidney disease from human iPS cells

Study could reveal brain cells and circuits that influence human health and metabolism in response to dietary changes

Event guide: 8th CKD Summit 2026 eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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