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New gold-nanoparticle probes for target identification of bioactive small molecules

The development of pharmaceutical treatments is difficult -- clinicians and researchers know a certain drug can regulate particular functions, but they might not know how it actually works.

1 Feb 2021

Study discovers promising therapeutic agent to inhibit melanoma progression

There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease.

1 Feb 2021

Study finds high bleeding risk in a sub-group of COVID-19 patients

The human body strives to keep itself in homeostasis, or balance. When blood clots are created, the body's innate response is to break the clots down to prevent significant health problems from arising.

1 Feb 2021

Study unravels relationship status of important receptor on immune and cancer cells

An important receptor on the surface of cancer and immune cells prefers to remain noncommittal; sometimes it is present as a single, sometimes as a pair. This was first shown by an MDC team in the journal PNAS, and will decisively advance the development of new medications.

30 Jan 2021

Scientists engineer potent trivalent inhibitors of thrombin

Thrombosis, the clogging of blood vessels, is a major cause of heart attacks and embolism. Scientists have now engineered the first inhibitors of thrombin, a protease promoting thrombosis, that is three-fold efficient.

29 Jan 2021

Researchers identify new strategy to protect offspring from prenatal stress

New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy.

29 Jan 2021

Scientists create new way to detect COVID-19 proteins and antibodies

Scientists have created a new way to detect the proteins that make up the pandemic coronavirus, as well as antibodies against it. They designed protein-based biosensors that glow when mixed with components of the virus or specific COVID-19 antibodies.

29 Jan 2021

Physicians receive Pfizer Prize for research on leukemia, cardiac arrhythmias

This year, four of a total of fifteen Pfizer Research Prizes have been awarded to physicians from the University of Bern and the Inselspital, University Hospital Bern.

28 Jan 2021

David Julius and Ardem Patapoutian receive Frontiers of Knowledge Award in Biology and Biomedicine

The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), "for identifying the receptors that enable us to sense temperature, pain and pressure."

28 Jan 2021

Scientists evaluate correlation between thin film structure and organic thin-film transistors performance

Benoît Lessard and his team are developing carbon-based technologies that could lead to improved flexible phone displays, make robotic skin more sensitive and allow for wearable electronics that could monitor the physical health of athletes in real-time.

28 Jan 2021

Innovative breakthrough promises to diagnose DNA rearrangement mutations

Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities.

28 Jan 2021

American scientists receive the 2021 Paul Ehrlich and Ludwig Darmstaedter Prize

FRANKFURT am MAIN. Two American scientists, Bonnie L. Bassler and Michael R. Silverman, receive the 2021 Paul Ehrlich and Ludwig Darmstaedter Prize, which is endowed with 120,000 €.

28 Jan 2021

Study: TALEN is five times more efficient than CRISPR-Cas9 in tightly packed DNA

Researchers used single-molecule imaging to compare the genome-editing tools CRISPR-Cas9 and TALEN.

27 Jan 2021

Remdesivir, given to half of hospitalized covid patients in U.S., is big win for Gilead — boosted by taxpayers

It was the end of April — just as the U.S. confirmed its millionth covid-19 case and 50,000 deaths — when White House adviser Dr. Anthony Fauci announced "highly significant" news about a drug called remdesivir.

27 Jan 2021

Allarity Therapeutics announces plans to test antiviral activity of stenoparib drug

Allarity Therapeutics of Hørsholm, Denmark, today announced plans to further test the antiviral activity of stenoparib, its PARP inhibitor, against SARS-CoV-2 lineage B.1.1.7, also known as Coronavirus Variant B117 (the "British variant"), at the COVID-19 Testing Service Center (CTSC) of Northern Arizona University's Pathogen and Microbiome Institute (PMI), a leading U.S. infectious disease testing center.

27 Jan 2021

New data shows that mINDY gene is involved in blood pressure regulation

Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the Journal of Clinical Investigation (JCI) insight.

27 Jan 2021

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer.

27 Jan 2021

Two-drug combination approach could be effective against bone cancer

An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis.

27 Jan 2021

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Now, in new research posted to the preprint server bioRxiv*, scientists use an experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) concerning ACE2 binding.

27 Jan 2021

Study shows why children of obese mothers have propensity to develop metabolic diseases

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research.

26 Jan 2021

Molecule News and Research

New gold-nanoparticle probes for target identification of bioactive small molecules

Study discovers promising therapeutic agent to inhibit melanoma progression

Study finds high bleeding risk in a sub-group of COVID-19 patients

Study unravels relationship status of important receptor on immune and cancer cells

Scientists engineer potent trivalent inhibitors of thrombin

Researchers identify new strategy to protect offspring from prenatal stress

Scientists create new way to detect COVID-19 proteins and antibodies

Physicians receive Pfizer Prize for research on leukemia, cardiac arrhythmias

David Julius and Ardem Patapoutian receive Frontiers of Knowledge Award in Biology and Biomedicine

Scientists evaluate correlation between thin film structure and organic thin-film transistors performance

Innovative breakthrough promises to diagnose DNA rearrangement mutations

American scientists receive the 2021 Paul Ehrlich and Ludwig Darmstaedter Prize

Study: TALEN is five times more efficient than CRISPR-Cas9 in tightly packed DNA

Remdesivir, given to half of hospitalized covid patients in U.S., is big win for Gilead — boosted by taxpayers

Allarity Therapeutics announces plans to test antiviral activity of stenoparib drug

New data shows that mINDY gene is involved in blood pressure regulation

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Two-drug combination approach could be effective against bone cancer

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Study shows why children of obese mothers have propensity to develop metabolic diseases

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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