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Cigarette smoke alters immune cell function in the lungs

Cigarette smoking is widespread and deadly, yet our understanding of how cigarette smoke actually causes serious respiratory illnesses is incomplete, which has severely hampered the development of effective treatments.

17 Jan 2025

Evaluating biomarkers for diagnosing minimal hepatic encephalopathy in cirrhotic patients

The performance of neurodegenerative biomarkers-neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau, and ubiquitin carboxy-terminal hydrolase L1 (UCHL1)-in diagnosing minimal hepatic encephalopathy (MHE) has not been systematically evaluated, simultaneously, nor have their associations with the development of overt hepatic encephalopathy (OHE).

17 Jan 2025

New rabbit model provides insights into CF-related pancreatic endocrine pathology

Cystic fibrosis (CF) is a life-threatening genetic disease affecting multiple organ systems, with pancreatic dysfunction representing a critical and often overlooked complication.

17 Jan 2025

SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development.

17 Jan 2025

DDR2 enhances BMP-dependent bone regeneration and reduces heterotopic ossification

Bone loss resulting from trauma, fractures, or disease presents a major global health challenge, often leading to long-term disability.

17 Jan 2025

The diverse immunological functions of megakaryocytes

Megakaryocytes (MKs), known for their role in platelet production, have emerged as critical players in immune responses, showcasing versatility in both physiological and pathological contexts.

17 Jan 2025

Study evaluates effectiveness and safety of TMF for chronic hepatitis B

Chronic hepatitis B (CHB) remains a significant global health challenge, and effective antiviral therapies are essential for long-term management.

17 Jan 2025

Researchers launch startup to revolutionize targeted drug delivery using milk exosomes

Two Nebraska researchers have launched a startup company aimed at bringing to market an innovative method for delivering therapeutics, gene editing tools, plasmids and more to targeted locations in the human body.

17 Jan 2025

New research identifies metabolic targets to combat antibiotic-resistant bacterial infections

Targeting unique metabolic pathways in pathogens offers a novel approach to precision antibiotics, addressing the growing challenge of antimicrobial resistance.

17 Jan 2025

New approach shows promise in fighting multiple cancers

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor's cancerous cells influence their surroundings, blocking the body's immune defenses and creating a sort of haven in which the tumor can grow. Treatments that target some of these pro-tumor actions are effective in a number of cancers, but only for some patients; in others, these treatments have little effect.

17 Jan 2025

Bidirectional movement drives DNA loop formation

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only. The discovery, which is published in Cell, is key to understanding how these motors shape our genome and regulate our genes.

17 Jan 2025

Explainable AI predicts ICU length of stay and guides clinical decision-making

Intensive care units (ICUs) face mounting pressure to effectively manage resources while delivering optimal patient care. Groundbreaking research published in the INFORMS journal Information Systems Research highlights how a novel artificial intelligence (AI) model is revolutionizing ICU care by not only improving predictions of patient length of stay, but also equipping clinicians with clear, evidence-based insights to guide critical decisions.

17 Jan 2025

AI deciphers intracellular signals from extracellular recordings in heart cells

A team of researchers led by the University of California San Diego and Stanford University has developed a noninvasive method to monitor the electrical activity inside heart muscle cells from the outside, avoiding the need to physically penetrate the cells.

16 Jan 2025

Brain stimulation enables nuanced feeling in prosthetic hands

You can probably complete an amazing number of tasks with your hands without looking at them. But if you put on gloves that muffle your sense of touch, many of those simple tasks become frustrating. Take away proprioception - your ability to sense your body's relative position and movement - and you might even end up breaking an object or injuring yourself.

16 Jan 2025

Non-toxic bacterial therapy shows promise for targeting tumors

A University of Massachusetts Amherst-Ernest Pharmaceuticals team of scientists has made "exciting," patient-friendly advances in developing a non-toxic bacterial therapy, BacID, to deliver cancer-fighting drugs directly into tumors.

16 Jan 2025

Scientists discover new mechanism behind Huntington’s disease brain cell death

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

16 Jan 2025

Alcohol consumption increases risks of cirrhosis and HCC in patients with HBV infection

The quantitative effects of alcohol consumption on cirrhosis and hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) infection are unknown.

16 Jan 2025

New resource from NCCN offers guidance on hereditary cancer risk

Today, the National Comprehensive Cancer Network (NCCN)-an alliance of leading cancer centers-published a new resource to inform people about the latest recommendations around hereditary and familial cancer risk.

16 Jan 2025

Immune system changes may predict antipsychotic resistance in schizophrenia Scientis...

Researchers from the National Healthcare Group (NHG)'s Institute of Mental Health (IMH) and Agency for Science, Technology and Research (A*STAR) have made strides in understanding the connection between the immune system and resistance to antipsychotic medications in schizophrenia, using changes in immune cell populations to predict potential treatment resistance and initiate the most appropriate treatment sooner.

16 Jan 2025

Wearable devices can identify and predict flare-ups in inflammatory bowel disease

Wearable devices can identify, differentiate, and predict flare-ups, or the worsening of symptoms and inflammation, in inflammatory bowel disease (IBD), Mount Sinai researchers have shown in a first-of-its-kind study.

16 Jan 2025

Technology News and Research

Cigarette smoke alters immune cell function in the lungs

Evaluating biomarkers for diagnosing minimal hepatic encephalopathy in cirrhotic patients

New rabbit model provides insights into CF-related pancreatic endocrine pathology

SOX9 overexpression protects against lipid accumulation in MASH via AMPK activation

DDR2 enhances BMP-dependent bone regeneration and reduces heterotopic ossification

The diverse immunological functions of megakaryocytes

Study evaluates effectiveness and safety of TMF for chronic hepatitis B

Researchers launch startup to revolutionize targeted drug delivery using milk exosomes

New research identifies metabolic targets to combat antibiotic-resistant bacterial infections

New approach shows promise in fighting multiple cancers

Bidirectional movement drives DNA loop formation

Explainable AI predicts ICU length of stay and guides clinical decision-making

AI deciphers intracellular signals from extracellular recordings in heart cells

Brain stimulation enables nuanced feeling in prosthetic hands

Non-toxic bacterial therapy shows promise for targeting tumors

Scientists discover new mechanism behind Huntington’s disease brain cell death

Alcohol consumption increases risks of cirrhosis and HCC in patients with HBV infection

New resource from NCCN offers guidance on hereditary cancer risk

Immune system changes may predict antipsychotic resistance in schizophrenia Scientis...

Wearable devices can identify and predict flare-ups in inflammatory bowel disease

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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