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New antibody strategy shows promise for halting cyst growth in polycystic kidney disease

Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the kidneys. Over time, the painful, growing cysts rob the organs of their function, often leading to dialysis in advanced cases.

18 Nov 2025

New AI investment aims to accelerate the search for an effective HIV vaccine

As of 2024, over 40 million people in the world are diagnosed with human immunodeficiency virus (HIV)-a chronic, life-threatening infection that remains one of the leading global causes of death.

18 Nov 2025

Tirzepatide reveals a brain signal that predicts returning food preoccupation

Researchers implanted electrodes in the human nucleus accumbens to track brain activity during severe food preoccupation in an individual taking tirzepatide. They found that a delta–theta biomarker disappeared during symptom-free periods and re-emerged weeks before relapse, suggesting a possible neural marker of vulnerability to dysregulated eating.

18 Nov 2025

Analysis finds even low-intensity smokers have higher risk of heart disease and death

An analysis of data from almost two dozen long-term studies finds that even low-intensity smokers have a substantially higher risk of heart disease and death compared to people who never smoked, even years after they quit.

18 Nov 2025

Scientists investigate the role of the extracellular matrix in tissue growth

Growing from a single cell into a complex organism with specialized tissues and organs requires a complex and coordinated process.

18 Nov 2025

Novel therapy reduces tumor growth in models of triple-negative breast cancer

Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and difficult-to-treat forms of the disease.

18 Nov 2025

New transplant approach resets the immune system to stop Type 1 diabetes

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured Type 1 diabetes in mice in a study by Stanford Medicine researchers.

18 Nov 2025

Early immunotherapy shows higher response in advanced basal cell carcinoma

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center found that patients with advanced basal cell carcinoma (BCC) may benefit from receiving immunotherapy earlier in the course of treatment.

18 Nov 2025

Scientists urge careful evaluation before applying AI virtual staining in healthcare workflows

Artificial intelligence has exploded in popularity in recent years, and many proponents are excited about its potential uses in medicine: for example, processing samples quickly or identifying markers of disease that may be missed by the human eye.

18 Nov 2025

Year-long adherence to buprenorphine sharply reduces overdose risk in young people

New research from Mass General Brigham finds that adolescents and young adults who stayed on the medication buprenorphine for at least a year had markedly lower risks of opioid overdose and hospitalization compared with peers who discontinued medication early or took it inconsistently.

18 Nov 2025

Study reveals how gestational diabetes disrupts the placenta at the molecular level

Gestational diabetes can cause a multitude of complications in the offspring, but to date, the reasons are incompletely understood.

18 Nov 2025

Acute and chronic depression involve different mechanisms in the brain

A new study investigating neuroinflammation in the ventral tegmental area (VTA) of the brain, a small, midbrain dopaminergic region, has found that acute and chronic depression are associated with distinct pathophysiological mechanisms.

18 Nov 2025

ESC launches its first Digital & AI Summit to advance cardiovascular innovation

The European Society of Cardiology (ESC) will host its first Digital & AI Summit in Berlin on 21-22 November, bringing together global experts in cardiology, technology, and healthcare.

18 Nov 2025

Climate extremes continue to drive preventable deaths across the United States

Researchers led by investigators at Mass General Brigham have discovered that over the last 25 years, heat and cold-related deaths have caused more than 69,000 deaths in the U.S., disproportionately affecting certain populations. The findings are published in the Annals of Internal Medicine.

18 Nov 2025