Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Experimental drug targets early toxic amyloid to slow Alzheimer’s disease

An experimental drug developed at Northwestern University has demonstrated further promise as an early intervention for Alzheimer's disease.

18 Dec 2025

Lysophosphatidylcholines show gene-dependent effects in early Alzheimer’s disease

A new study presents robust evidence on the role of lysophosphatidylcholines (LPCs) in the onset of Alzheimer's disease. Researchers discovered that LPCs-compounds that transport a variety of healthy fatty acids to the brain-either promote Alzheimer's or protect against it, depending on a person's genetics.

17 Dec 2025

Hyperphosphorylated tau may help protect the brain from infection

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it starts to stick together and form clumps called "tangles" inside of brain nerve cells.

17 Dec 2025

Urine-based microRNA clock predicts biological aging without a blood test

Researchers developed and validated a non-invasive urinary microRNA aging clock using extracellular vesicle miRNAs from more than 6,000 adults. The model predicts age with about 4 to 5 years error and links accelerated aging signals to type 2 diabetes.

16 Dec 2025

Pathology AI models show demographic bias in cancer diagnosis

Pathology has long been the cornerstone of cancer diagnosis and treatment. A pathologist carefully examines an ultrathin slice of human tissue under a microscope for clues that indicate the presence, type, and stage of cancer.

16 Dec 2025

Tau biology expands beyond microtubules to neurodegeneration, metabolism and mental illness

An Thought Leaders Invited Review published today in Genomic Psychiatry by Dr. Peng Lei and colleagues presents a sweeping synthesis of tau protein research that fundamentally reframes our understanding of this molecule's dual identity.

16 Dec 2025

Researchers block virus entry by targeting key protein interaction

Washington State University researchers have found a way to modulate a common virus protein to prevent viruses from entering cells where it can cause illness, a discovery that could someday lead to new antiviral treatments.

15 Dec 2025

Tiny blood particles help shuttle a hormone through the body

Researchers at Touro University Nevada have discovered that tiny particles in the blood, called extracellular vesicles (EVs), are a major player in how a group of hormones are shuttled through the body. Physical exercise can stimulate this process.

15 Dec 2025

Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract.

12 Dec 2025

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

The interaction between genetics and tissue environment shapes how individual teeth form in different regions of the jaw.

12 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Learn how digital connectivity and the PathoVerse are improving pathology workflows and accelerating access to expert diagnostics.

From PathPresenter 12 Dec 2025

What happens to your body when you eat takeaway food too often?

This study of 8,556 US adults shows that frequent takeaway food consumption is associated with a higher energy-adjusted Dietary Inflammatory Index and adverse cardiometabolic markers. The findings suggest that reducing takeaway intake and lowering dietary inflammatory potential may improve long-term cardiometabolic health.

11 Dec 2025

Study reveals how Ebola and Marburg viruses damage the human gut

Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively damaging the body.

11 Dec 2025

AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Study offers a unified biological model to explain the causes of autism

A new University of California San Diego School of Medicine study offers a unified biological model to explain how genetic predispositions and environmental exposures converge to cause autism spectrum disorder (ASD).

10 Dec 2025

Mammary glands of domesticated livestock and humans could harbor avian influenza

An ongoing outbreak of highly pathogenic avian influenza has affected more than 184 million domestic poultry since 2022 and, since making the leap to dairy cattle in spring 2024, more than 1,000 milking cow herds.

9 Dec 2025

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

UCI MIND secures major funding for new Alzheimer's research facility

With a $50 million lead gift from the Quilter family and approximately $30 million in new commitments, the University of California, Irvine's Institute for Memory Impairments and Neurological Disorders will begin planning to build a state-of-the-art research and care facility to enhance its position as a global leader in Alzheimer's disease and related dementias research and patient care.

8 Dec 2025

Pathology News and Research

Further Reading

Experimental drug targets early toxic amyloid to slow Alzheimer’s disease

Lysophosphatidylcholines show gene-dependent effects in early Alzheimer’s disease

Hyperphosphorylated tau may help protect the brain from infection

Urine-based microRNA clock predicts biological aging without a blood test

Pathology AI models show demographic bias in cancer diagnosis

Tau biology expands beyond microtubules to neurodegeneration, metabolism and mental illness

Researchers block virus entry by targeting key protein interaction

Tiny blood particles help shuttle a hormone through the body

Over-contracted gut muscles drive gastrointestinal symptoms in myotonic dystrophy

Distinct transcriptomic profiles guide early development of maxillary and mandibular teeth

Mass General Brigham launches AI company to enhance clinical trial matching

Digital pathology and the PathoVerse: A conversation with Dr. Singh

What happens to your body when you eat takeaway food too often?

Study reveals how Ebola and Marburg viruses damage the human gut

AI turns routine pathology slides into powerful maps of the tumor immune landscape

Study offers a unified biological model to explain the causes of autism

Mammary glands of domesticated livestock and humans could harbor avian influenza

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

UCI MIND secures major funding for new Alzheimer's research facility

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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