Preclinical News and Research

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Alcohol consumption linked to higher prevalence of sarcopenia in postmenopausal women

If you feel as though you can't do as much physically as you've gotten older, there may be a reason. Both aging and menopause are known to affect sarcopenia, which is a loss of muscle mass and strength, which in turn affects balance, gait, and overall ability to perform tasks of daily living.

7 Jun 2017

Anti-heroin vaccine developed at TSRI proven effective in primate models

A vaccine developed at The Scripps Research Institute (TSRI) to block the "high" of heroin has proven effective in non-human primates. This is the first vaccine against an opioid to pass this stage of preclinical testing.

6 Jun 2017

Chronic pain may occur when receptors migrate from nerve cell's surface to inner chambers

A study led by Columbia University Medical Center has shown that chronic pain may occur when pain receptors migrate from the nerve cell's surface to the cell's inner chambers, out of the reach of current pain medications.

1 Jun 2017

Scientists report discovery and validation of drug candidate for treating cryptosporidiosis

Infectious disease scientists from Novartis, the University of Georgia and Washington State University have reported the discovery and early validation of a drug candidate for treating cryptosporidiosis, a diarrheal disease which is a major cause of child mortality in lower-income countries. Currently there are no vaccines or effective treatments.

31 May 2017

Cognitive tests can detect early Alzheimer's in people without symptoms, study suggests

Long before symptoms of Alzheimer's disease become apparent to patients and their families, biological changes are occurring within the brain. Amyloid plaques, which are clusters of protein fragments, along with tangles of protein known as tau, form in the brain and grow in number, eventually getting in the way of the brain's ability to function.

31 May 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

Investigational compound inhibits cancer-specific mutations in mice

Many malignancies develop as a result of genetic alterations in individual cells. These gene mutations often cause altered proteins that give new, growth-promoting properties to the cell.

30 May 2017

Radiopharmaceutical for cancer diagnosis is ready for preclinical-phase trial

A radiopharmaceutical for advanced identification of cancer, labeled with the technetium-99 isotope, is ready for the preclinical-phase trial.

30 May 2017

Gene editing technology can introduce hundreds of unintended mutations, study shows

As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.

29 May 2017

Study uncovers stroke risk factors for pregnant women with preeclampsia

Women with preeclampsia, a common complication of pregnancy, face a heightened risk of stroke during pregnancy and postpartum if they have urinary tract infections, chronic high blood pressure, or clotting or bleeding disorders, according to a study by Columbia University Medical Center and NewYork-Presbyterian researchers.

25 May 2017

BGU researchers redesign portion of FDA-approved drug into new molecule to treat ALS

Ben-Gurion University of the Negev researchers are developing a new therapy for Amyotrophic Lateral Sclerosis using part of an existing FDA-approved drug that restores the central nervous system's (CNS) immune defenses and increases life expectancy.

25 May 2017

Frequent recreational cannabis use linked to increased risk of gum disease

Columbia University dental researchers have found that frequent recreational use of cannabis--including marijuana, hashish, and hash oil--increases the risk of gum disease.

24 May 2017

Probiotics could help improve gut symptoms and psychological issues in IBS, study shows

Probiotics may relieve symptoms of depression, as well as help gastrointestinal upset, research from McMaster University has found.

23 May 2017

Researchers develop new biomedical polymer to treat atherosclerosis

Researchers at Ben-Gurion University and the Sheba Medical Center have developed a new therapy to treat atherosclerosis and prevent heart failure with a new biomedical polymer that reduces arterial plaque and inflammation in the cardiovascular system.

22 May 2017

Seventh Wave announces collaboration with Yecuris to study new liver disease therapies

Seventh Wave Laboratories, a consulting-based contract research organization that assesses the safety and efficacy of pharmaceutical products and medical devices, has announced an exclusive collaboration with Yecuris Corporation, a global leader in the development and use of humanized models in drug development research.

18 May 2017

MR Solutions to showcase latest MRI imaging technology at World Preclinical Congress in Boston

MR Solutions, with offices in the UK and Boston, will be showing their latest state of the art 3T to 9.4T superconducting, cryogen-free MRI imaging technology with optional PET and SPECT imaging modalities on stand 407 at the 16th annual World Preclinical Congress in Boston on June 13th to 15th. The congress focusses on the very latest trends and technologies impacting the preclinical drug discovery and development world.

18 May 2017

Study unravels new clues to cause and treatment of spinal muscular atrophy

Spinal muscular atrophy, a neurodegenerative disease that causes progressive muscle wasting and paralysis, may be partly due to abnormalities in the synapses that connect sensory neurons and motor neurons, according to researchers at Columbia University Medical Center.

16 May 2017

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.

12 May 2017

TUM scientists develop new pH sensor that provides insights into tumor metabolism

Tumors, inflammation and circulatory disorders locally disturb the body's acid-base balance. These changes in pH value could be used for example to verify the success of cancer treatments.

12 May 2017

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Solid Biosciences announced today that new data from two preclinical studies reinforce the potential of its investigational microdystrophin gene therapy, SGT-001, to be an effective treatment approach for Duchenne muscular dystrophy.

11 May 2017

Preclinical News and Research

Alcohol consumption linked to higher prevalence of sarcopenia in postmenopausal women

Anti-heroin vaccine developed at TSRI proven effective in primate models

Chronic pain may occur when receptors migrate from nerve cell's surface to inner chambers

Scientists report discovery and validation of drug candidate for treating cryptosporidiosis

Cognitive tests can detect early Alzheimer's in people without symptoms, study suggests

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Investigational compound inhibits cancer-specific mutations in mice

Radiopharmaceutical for cancer diagnosis is ready for preclinical-phase trial

Gene editing technology can introduce hundreds of unintended mutations, study shows

Study uncovers stroke risk factors for pregnant women with preeclampsia

BGU researchers redesign portion of FDA-approved drug into new molecule to treat ALS

Frequent recreational cannabis use linked to increased risk of gum disease

Probiotics could help improve gut symptoms and psychological issues in IBS, study shows

Researchers develop new biomedical polymer to treat atherosclerosis

Seventh Wave announces collaboration with Yecuris to study new liver disease therapies

MR Solutions to showcase latest MRI imaging technology at World Preclinical Congress in Boston

Study unravels new clues to cause and treatment of spinal muscular atrophy

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

TUM scientists develop new pH sensor that provides insights into tumor metabolism

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

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