Therapy News and Research

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No difference in health outcomes between 24-hour and 15-hour oxygen therapy

There were no differences in quality of life, symptoms, hospital admissions or mortality between a group of patients with pulmonary disease and low oxygen levels in the blood that received oxygen therapy at home for 24 hours a day, and a group that received the same therapy for 15 hours a day, according to a study from Lund University in Sweden.

12 Sep 2024

Early Phase I data shows promise for mRNA cancer immunotherapy in advanced solid cancers

Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

12 Sep 2024

Fear of hypoglycemia limits physical activity in adults with type 1 diabetes

Despite high use of continuous glucose monitoring and insulin pump therapy, fear of hypoglycemia (low blood sugar) remains a significant barrier to physical activity and exercise for adults with type 1 diabetes (T1D), according to new research to be presented at this year's Annual Meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept).

12 Sep 2024

New discovery offers hope for overcoming CAR-T cell therapy resistance

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

12 Sep 2024

Nucleophagy identified as key DNA repair mechanism in cancer treatments

A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is particularly relevant for patients undergoing colorectal cancer treatments.

12 Sep 2024

Five key factors identified for predicting immunotherapy response in cancer patients

Immunotherapy has transformed cancer treatment in recent years by enabling the immune system to attack tumor cells.

12 Sep 2024

Duffy-null phenotype may lead to unfair exclusion from cancer drug trials

Many clinical trials of new cancer drugs may be inappropriately excluding some people with "Duffy-null phenotype," a trait found predominantly in people of African or Middle Eastern descent, researchers at Dana-Farber Cancer Institute and Queen Mary University of London report in a new study.

12 Sep 2024

New IndiPHARM initiative aims to revolutionize personalized medication management

A Columbia University-led multicenter research effort called IndiPHARM: individual metabolome and exposome assessment for pharmaceutical optimization will develop a platform and monitoring system to prevent unwanted interactions between medications and other environmental, genetic, and lifestyle factors, in order to optimize therapeutic efficacy.

12 Sep 2024

Machine learning reveals sleep quality and anxiety as major predictors of depression

Researchers applied machine learning to predict depressive symptoms, revealing sleep quality and anxiety as key factors across diverse populations and datasets.

12 Sep 2024

Researchers uncover why typically normal protein drives prostate cancer

NSD-2 is crucial for AR activity in prostate cancer, promoting tumor growth and offering a potential therapeutic target for advanced prostate cancer treatment.

12 Sep 2024

Laughter exercise could be an initial treatment for relieving dry eye disease symptoms

Laughter may be as effective as eye drops in improving symptoms of dry eye disease, finds a clinical trial from China published by The BMJ today.

11 Sep 2024

Long radiotherapy course shows better organ preservation in rectal cancer

The COVID-19 pandemic has enabled researchers to show that a long course of radiotherapy given before surgery may be a better treatment for avoiding surgery, preserving the rectum and anus, and preventing regrowth of the primary tumor than a short course of radiotherapy for patients with rectal cancer – a type of bowel cancer.

11 Sep 2024

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

The c-Met-directed antibody-drug conjugate telisotuzumab vedotin demonstrated durable responses and an acceptable safety profile in patients of Asian race with c-Met protein-overexpressing, epidermal growth factor receptor (EGFR) wildtype (WT), locally advanced/metastatic nonsquamous non-small cell lung cancer (NSCLC), according to research presented today at the International Association for the Study of Lung Cancer's 2024 World Conference on Lung Cancer.

11 Sep 2024

Study shows CAR T-cell therapy's risk of second primary malignancies comparable to other treatments

The frequency of second primary malignancies (SPMs) arising in cancer survivors following treatment with CAR T-cell therapy was statistically comparable to the frequency of SPMs following other standard-of-care therapies, according to a systematic review and meta-analysis.

11 Sep 2024

Zongertinib shows promising efficacy in HER2 mutation-positive NSCLC

The HER2-specific tyrosine kinase inhibitor zongertinib was well tolerated and demonstrated promising efficacy in patients with HER2 mutation-positive non-small cell lung cancer, meeting the primary endpoint of the Beamion LUNG-1 Phase Ib Cohort 1 study, according to research presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer.

11 Sep 2024

Pre-surgery chemotherapy shows promise for preserving vital organs in nasal and sinus cancer

Results from a clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) show a striking improvement for patients who received chemotherapy before surgery to remove advanced squamous cell-type cancer of the nose or sinus.

11 Sep 2024

World champion marathon runner’s life study highlights benefits and risks of life-long endurance exercise

Decades of intense marathon training have preserved heart function in a 77-year-old, highlighting benefits and risks of extreme endurance exercise.

11 Sep 2024

New study links gut bacteria to thiamine's role in reducing fatigue in IBD patients

Researchers explore the frequency of symptoms like chronic fatigue in IBD in relation to specific bacteria in the human gut.

11 Sep 2024

New study explores the potential of hormone therapy for opioid recovery

In the midst of America's growing opioid crisis, a much healthier alternative to long-term pain management is emerging - one affectionately known as "the cuddle hormone," or oxytocin.

11 Sep 2024

Addressing the challenges of polycystic kidney disease

Polycystic kidney disease (PKD) is an intractable disorder that causes fluid-filled cysts to grow in the kidneys. It is typically seen in adults. As one of the most prevalent hereditary kidney diseases, the autosomal dominant form of PKD is usually caused by mutations in the PKD1 and PKD2 genes.

11 Sep 2024

Therapy News and Research

No difference in health outcomes between 24-hour and 15-hour oxygen therapy

Early Phase I data shows promise for mRNA cancer immunotherapy in advanced solid cancers

Fear of hypoglycemia limits physical activity in adults with type 1 diabetes

New discovery offers hope for overcoming CAR-T cell therapy resistance

Nucleophagy identified as key DNA repair mechanism in cancer treatments

Five key factors identified for predicting immunotherapy response in cancer patients

Duffy-null phenotype may lead to unfair exclusion from cancer drug trials

New IndiPHARM initiative aims to revolutionize personalized medication management

Machine learning reveals sleep quality and anxiety as major predictors of depression

Researchers uncover why typically normal protein drives prostate cancer

Laughter exercise could be an initial treatment for relieving dry eye disease symptoms

Long radiotherapy course shows better organ preservation in rectal cancer

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

Study shows CAR T-cell therapy's risk of second primary malignancies comparable to other treatments

Zongertinib shows promising efficacy in HER2 mutation-positive NSCLC

Pre-surgery chemotherapy shows promise for preserving vital organs in nasal and sinus cancer

World champion marathon runner’s life study highlights benefits and risks of life-long endurance exercise

New study links gut bacteria to thiamine's role in reducing fatigue in IBD patients

New study explores the potential of hormone therapy for opioid recovery

Addressing the challenges of polycystic kidney disease

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