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Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

Significant improvement in progression-free survival and response rate combined with reduced symptoms and better quality of life are reported as outcomes of a new treatment approach for patients with desmoid tumors, which are benign, but locally aggressive and invasive soft tissue tumors.

12 Sep 2022

COVID-19 drugs persist through wastewater treatment, may negatively affect aquatic organisms

Certain drugs used to treat COVID-19 patients -; including remdesivir, dexamethasone and antibiotics for associated bacterial infections -; persist through wastewater treatment and may occur in waterways at levels high enough to negatively affect aquatic organisms, according to a new study led by researchers at Penn State.

12 Sep 2022

Did the US jump the gun with the new omicron-targeted vaccines?

Last month, the FDA authorized omicron-specific vaccines, accompanied by breathless science-by-press release and a media blitz.

12 Sep 2022

‘An Arm and a Leg’: The new cap on Medicare drug costs

On a Sunday afternoon in August, health services researcher Stacie Dusetzina was sitting alone in her office at Vanderbilt University, watching C-SPAN and crying.

12 Sep 2022

Novel tests detect common cancer signals across over 50 types of cancer

Cancer doctors, care providers and payers need to get ready for a major shift in early cancer detection that will affect almost every stage of cancer diagnosis and treatment. New data supporting the accuracy of multi-cancer early detection (MCED) blood testing (1), presented at the ESMO Congress 2022, have major implications for future cancer care provision, said Fabrice André, ESMO 2022 Scientific Co-Chair.

12 Sep 2022

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial.

12 Sep 2022

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Using a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.

9 Sep 2022

Cannabis legalization likely to reduce conventional pharmaceutical sales by billions of dollars

Researchers from California Polytechnic State University and The University of New Mexico find that stock market investors predict cannabis legalization will reduce conventional pharmaceutical sales by billions of dollars.

2 Sep 2022

Brain activity patterns during sleep shed light on the neurobiology behind 22q11.2 Deletion Syndrome

The brain activity patterns during sleep shed light on the neurobiology behind a genetic condition called 22q11.2 Deletion Syndrome (22q11.2DS) and could be used as a biomarker to detect the onset of neuropsychiatric disorders in people with 22q11.2DS.

30 Aug 2022

Full-dose anticoagulation lowers the risk of blood clotting complications in COVID-19 patients

A clinical trial of patients with COVID-19 led by investigators at the TIMI Study Group at Brigham and Women's Hospital and the Critical Care Cardiology Trials Network has found that full-dose anticoagulation lowers the risk of blood clotting complications compared with standard-dose prophylactic anticoagulation.

29 Aug 2022

Congressman’s wife died after taking herbal remedy marketed for diabetes and weight loss

The wife of a Northern California congressman died late last year after ingesting a plant that is generally considered safe and is used as an herbal remedy for a variety of ailments, including diabetes, obesity, and high cholesterol, KHN has learned.

24 Aug 2022

Direct acting antiviral medications for hepatitis C may improve PTSD symptoms

More than six percent of Americans will develop posttraumatic stress disorder (PTSD) in their lifetime. This potentially chronic condition disrupts lives, and can lead to or exacerbate existing health issues such as depression, anxiety, eating disorders, and suicidal thoughts.

22 Aug 2022

Combination of new testing methods helps identify multiple dementia risk genes

A new UCLA-led study has identified multiple new risk genes for Alzheimer's disease and a rare, related brain disorder called progressive supranuclear palsy (PSP) by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment.

18 Aug 2022

Discovery explains how impaired metabolism triggers neuroendocrine tumors in the adrenal glands

Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands.

16 Aug 2022

Big pharma went all in to kill drug pricing negotiations

For decades, the drug industry has yelled bloody murder each time Congress considered a regulatory measure that threatened its profits.

12 Aug 2022

Health inequalities amongst ethnic minorities with diabetes have worsened during the pandemic, study shows

Existing health disparities amongst ethnic minorities with diabetes have worsened during the COVID-19 pandemic, a new study published in the journal Diabetes Care has reported.

11 Aug 2022

No, the Senate-passed reconciliation bill won’t strip $300 billion from Medicare

As Senate Democrats raced to pass what could be their final piece of major legislation before the midterm elections, critics went to the airwaves to blast the proposal as hurting older Americans who rely on Medicare.

11 Aug 2022

International medical experts aim to use biomarker-based approaches to advance precision medicine

The diagnostics company SphingoTec GmbH (SphingoTec), announces that, during the 4th Scientific Symposium held near Potsdam, Germany, international medical experts discussed the latest developments in diagnostic and therapeutic innovations for advancing precision medicine in critically ill patients.

11 Aug 2022

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.

9 Aug 2022

Researchers unravel a novel molecular target of eicosapentaenoic acid

Eicosapentaenoic acid (EPA) is an essential nutrient belonging to the omega-3 group of polyunsaturated fatty acids (PUFAs). As the human body cannot synthesize PUFAs, dietary supplements containing EPA are required for normal physiological functions. Found abundantly in natural sources like fish, hemp oil, and linseed oil, EPA is known to exhibit anti-inflammatory, neuroprotective, and cardiovascular protective activities.

9 Aug 2022

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Pharmaceuticals News and Research

Targeting the Notch pathway with gamma secretase inhibitor improves outcomes in patients with rare cancers

COVID-19 drugs persist through wastewater treatment, may negatively affect aquatic organisms

Did the US jump the gun with the new omicron-targeted vaccines?

‘An Arm and a Leg’: The new cap on Medicare drug costs

Novel tests detect common cancer signals across over 50 types of cancer

Tumor-infiltrating lymphocytes therapy treats cancers at a large scale

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Cannabis legalization likely to reduce conventional pharmaceutical sales by billions of dollars

Brain activity patterns during sleep shed light on the neurobiology behind 22q11.2 Deletion Syndrome

Full-dose anticoagulation lowers the risk of blood clotting complications in COVID-19 patients

Congressman’s wife died after taking herbal remedy marketed for diabetes and weight loss

Direct acting antiviral medications for hepatitis C may improve PTSD symptoms

Combination of new testing methods helps identify multiple dementia risk genes

Discovery explains how impaired metabolism triggers neuroendocrine tumors in the adrenal glands

Big pharma went all in to kill drug pricing negotiations

Health inequalities amongst ethnic minorities with diabetes have worsened during the pandemic, study shows

No, the Senate-passed reconciliation bill won’t strip $300 billion from Medicare

International medical experts aim to use biomarker-based approaches to advance precision medicine

Mount Sinai receives $500,000 SU2C grant to identify therapeutic combinations for KRAS-mutant lung cancers

Researchers unravel a novel molecular target of eicosapentaenoic acid

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