Genomic News and Research

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Autism risk in children could be predicted by mutations in paternal sperm

Researchers from the University of California, San Diego, have found that mutations present in the sperms of the father could be predictors of autism in the offspring, in a landmark study. These mutations, if quantified could help ascertain the risk say the researchers. The new study appears this week in the latest issue of the journal Nature Medicine.

23 Dec 2019

New, faster and cheaper method to uncover genetic variants in single cells

Researchers led by the European Molecular Biology Laboratory in Heidelberg and the Center for Bioinformatics at Saarland University in Saarbrücken, Germany, have developed a cheaper and faster method to check for genetic differences in individual cells, which outperforms existing techniques with respect to the information received.

23 Dec 2019

Genomic data can accurately and reliably predict stroke risk

Estimates based on genomic data predict stroke risk with an accuracy similar to, or greater than those based on clinical risk factors. This result implies that persons at high risk might benefit from more rigorous preventive measures.

21 Dec 2019

Researchers develop powerful computer algorithm for large-scale genomic analysis

Haplotypes are a set of genetic variations that, located side by side on the same chromosome, are transmitted in a single group to the next generation. Their examination makes it possible to understand the heritability of certain complex traits, such as the risk of developing a disease.

20 Dec 2019

Combined datasets can expedite the discovery and development of new cancer drugs

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types.

20 Dec 2019

New genetic score is similar or more predictive than common risk factors for stroke

A group of investigators from Australia, Germany, and the UK have shown that genetic data obtained from a single blood draw or saliva sample can be used to identify individuals at a 3-fold increased risk of developing ischemic stroke, a devastating condition and one of the leading causes of disability and death world-wide.

20 Dec 2019

Connection between herpes virus and Alzheimer’s refuted

A new study has shown that unlike previous claims, there is no association between getting herpes infections and developing Alzheimer’s disease. The study from the researchers at the Baylor College of Medicine was titled, “Are HHV-6A and HHV-7 really more abundant in Alzheimer’s disease?” and was published in the journal Neuron.

19 Dec 2019

Scientists create new classification system for tumors

Based on the largest study of cancer patients of its kind, scientists have created a new way of classifying tumors.

19 Dec 2019

A new book on ovarian cancer

An opening discussion of contemporary management of this disease presents commentary on surgery and clinical trials: neoadjuvant, dose-dense, and heated intraperitoneal chemotherapy (HIPEC}, as well as immunotherapy, vaccine therapy, emerging therapies.

18 Dec 2019

A fast, sensitive technique to detect cancer markers brings liquid biopsy closer to clinic

A fast, inexpensive yet sensitive technique to detect cancer markers is bringing researchers closer to a "liquid biopsy" - a test using a small sample of blood or serum to detect cancer, rather than the invasive tissue sampling routinely used for diagnosis.

18 Dec 2019

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

It seems that chewing gum is not a new trend! Researchers have found chewing gum that is 5,700 years old and it has provided clues regarding ancient DNA. A study with the findings was published in the journal Nature Communications. It is titled, “A 5,700-year-old human genome and oral microbiome from chewed birch pitch.”

18 Dec 2019

Different mutations in a single gene can have myriad effects on a person's health

Mount Sinai researchers have found that different mutations in a single gene can have myriad effects on a person's health, suggesting that gene therapies may need to do more than just replenish the missing or dysfunctional protein the gene is supposed to encode, according to a study published in Nature Genetics in November.

18 Dec 2019

Study provides insight into brain mechanisms underlying compulsive drinking

Compulsive drinking may be due to dysfunction in a specific brain pathway that normally helps keep drinking in check. The results are reported in the journal Biological Psychiatry.

18 Dec 2019

Researchers identify frequent technical bias in data generated by RNA-seq technology

Reproducibility of research data is a major challenge in experimental biology. As data generated by genomic-scale techniques increases in complexity, this concern is becoming more and more worrisome.

18 Dec 2019

Study provides genomic insights into life history tradeoffs in butterflies

Have you ever wandered through your garden or a meadow on a summer day and wondered why and how butterflies exhibit such beautiful and diverse colors? Scientists have, especially when thinking about butterflies in the genus Colias. In most Colias butterflies, all males and most females are an orange or yellow color, but some females are white.

18 Dec 2019

New method identifies harmful bacteria in less time and at a very low cost

A new bacterial identification method, called ON-rep-seq, examines selective, strain-specific fragments of the bacterial genome, allowing the generation of results that earlier required DNA sequencing of the entire bacterial genome or tedious approaches like pulsed field gel electrophoresis, which previously has been the golden the standard for strain-level typing of microorganisms.

18 Dec 2019

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.

17 Dec 2019

Penn researchers track defective sperm epigenome linked to male infertility

One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm that fail to "evict" proteins called histones from DNA during development.

16 Dec 2019

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Investigators at Rutgers Cancer Institute of New Jersey have found that a treatment based on a novel cellular product programmed to deliver an overabundance of chimeric antigen receptor causes cell death in non-Hodgkin lymphoma models that are sensitive or resistant to standard therapies.

16 Dec 2019

Important discovery about male infertility could lead to new treatments

Using a new mouse model, Penn Medicine researchers have identified defects in the sperm epigenome that cause male infertility.

16 Dec 2019

Genomic News and Research

Autism risk in children could be predicted by mutations in paternal sperm

New, faster and cheaper method to uncover genetic variants in single cells

Genomic data can accurately and reliably predict stroke risk

Researchers develop powerful computer algorithm for large-scale genomic analysis

Combined datasets can expedite the discovery and development of new cancer drugs

New genetic score is similar or more predictive than common risk factors for stroke

Connection between herpes virus and Alzheimer’s refuted

Scientists create new classification system for tumors

A new book on ovarian cancer

A fast, sensitive technique to detect cancer markers brings liquid biopsy closer to clinic

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

Different mutations in a single gene can have myriad effects on a person's health

Study provides insight into brain mechanisms underlying compulsive drinking

Researchers identify frequent technical bias in data generated by RNA-seq technology

Study provides genomic insights into life history tradeoffs in butterflies

New method identifies harmful bacteria in less time and at a very low cost

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Penn researchers track defective sperm epigenome linked to male infertility

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Important discovery about male infertility could lead to new treatments

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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