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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

Researchers develop new method for rapidly detecting SARS-CoV-2 RNA

DTU-researchers develop a novel method for rapidly detecting SARS-CoV-2 RNA that may also be designed to detect other diseases.

27 Sep 2021

Characterization of SARS-CoV-2 infections diagnosed after mRNA BNT162b2 vaccination

A team from the National Institute for Infectious Diseases “L. Spallanzani” (INMI) has recently reported their study on 94 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections (47.9% symptomatic, 52.1% asymptomatic) that occurred after the first or second vaccine dose against SARS-CoV-2 in the Lazio region (Central Italy).

27 Sep 2021

mRNA COVID vaccines prove effective in the elderly

Coronavirus disease 2019 (COVID-19) proved extremely difficult to control once it entered a country – while there were a few success stories such as New Zealand, most countries ended up resorting to lengthy and economically painful lockdowns, among other restriction measures.

27 Sep 2021

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Twist Bioscience Corporation (Nasdaq: TWST) today reported that its internally-discovered antibody candidate TB202-3 (CoVIC-094), demonstrated potent binding to diverse SARS-CoV-2 variant mutations, including strains with the E484K, N501Y, D614G, Y453F and K417N mutations in pseudovirus assays, indicating this therapeutic antibody may be effective in treating many strains of COVID-19.

25 Sep 2021

Researchers describe a novel role for hnRNP E1 protein in binding DNA in the nucleus

Cancer is a devastating disease and is the second leading cause of death in the U.S. One of the hallmarks of cancer is genomic instability, or the tendency to accumulate mutations and damage to the DNA that leads to genome alterations during cell division.

25 Sep 2021

3D-printed vaccine patch provides greater protection than a typical vaccine shot

Scientists at Stanford University and the University of North Carolina at Chapel Hill have created a 3D-printed vaccine patch that provides greater protection than a typical vaccine shot.

25 Sep 2021

Penn scientists win 2021 Lasker Award for the discovery of therapeutic mRNA technology

As mRNA-based SARS-CoV-2 vaccines are deployed to protect hundreds of millions of people across the world and point the way to end the deadly global COVID-19 pandemic, the University of Pennsylvania scientists whose prescient discovery science effort laid the foundation for swift vaccine development have been awarded the 2021 Lasker~DeBakey Clinical Medical Research Award.

24 Sep 2021

Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

Neuroinflammation can worsen outcomes in stroke, traumatic brain injury, or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson's, or Alzheimer's. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that are driven by neuroinflammation.

24 Sep 2021

Exploring the polymerase of poxviruses at an atomic level

Poxviruses have found a unique way of translating their genes into proteins in the infected organism. A team of researchers from Würzburg shows for the first time how the molecular machinery involved works at an atomic level.

24 Sep 2021

Using air filtration to remove airborne SARS-CoV-2 and other microbial aerosols in COVID wards

University of Cambridge researchers conducted a study in two repurposed COVID-19 units in Addenbrooke’s Hospital, Cambridge, UK, between January and February 2021. During this time, the alpha variant (lineage B1.1.7) accounted for >80% of the circulating SARS-CoV-2. This study, posted to the medRxiv* preprint server, aimed to provide evidence of the removal of SARS-CoV-2 and microbial bioaerosols using portable air filters with UV sterilization.

24 Sep 2021

Mathematical constructions of SARS-CoV-2 action could help fine-tune prevention and treatment

Mathematical constructions of the action of SARS-CoV-2 and its multiple spikes, which enable its success at infecting cells, can give vaccine developers and pharmaceutical companies alike a more precise picture of what the virus is doing inside us and help fine tune prevention and treatment, mathematical modelers say.

23 Sep 2021

Potential covalent SARS-CoV-2 spike protein inhibitors

There remains a significant need for new and effective drugs that can be used to treat COVID-19.

23 Sep 2021

Design of mRNA vaccines to combat COVID-19

A recent review study discusses fundamental concepts in the successful delivery of nucleic acids in therapeutics.

23 Sep 2021

New discovery offers clues to overcoming resistance to cancer therapies

Cancer cells proliferate despite a myriad of stresses - from oxygen deprivation to chemotherapy - that would kill any ordinary cell.

23 Sep 2021

Differences in blood gene expression among patients with varying COVID-19 severity

A new study published on the medRxiv* pre-print server and currently undergoing peer-review aims to answer this question through whole blood transcriptomics of individuals with varying degrees of COVID-19 severity. Transcriptomics, done by RNA sequencing, gives insights into the genes expressed in a cell at a given time point. It gives an analysis of all RNA molecules within a cell, in this case, whole blood.

23 Sep 2021

RNA News and Research

Further Reading

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

Researchers develop new method for rapidly detecting SARS-CoV-2 RNA

Characterization of SARS-CoV-2 infections diagnosed after mRNA BNT162b2 vaccination

mRNA COVID vaccines prove effective in the elderly

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Researchers describe a novel role for hnRNP E1 protein in binding DNA in the nucleus

3D-printed vaccine patch provides greater protection than a typical vaccine shot

Penn scientists win 2021 Lasker Award for the discovery of therapeutic mRNA technology

Small molecule drug can attenuate the triggers of neuroinflammation, preclinical study shows

Exploring the polymerase of poxviruses at an atomic level

Using air filtration to remove airborne SARS-CoV-2 and other microbial aerosols in COVID wards

Mathematical constructions of SARS-CoV-2 action could help fine-tune prevention and treatment

Potential covalent SARS-CoV-2 spike protein inhibitors

Design of mRNA vaccines to combat COVID-19

New discovery offers clues to overcoming resistance to cancer therapies

Differences in blood gene expression among patients with varying COVID-19 severity

Discovery points toward a new strategy for treating Parkinson's disease

DNA sensor can detect infectious viruses in minutes

Study reveals why SARS-CoV-2 is more infectious than SARS-CoV-1

Researchers use new laser-assisted technology for bioprinting adult neuron cells

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