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New modeling approach to better understand how tumors become aggressive

Although the development of secondary cancerous growths, called metastasis, is the primary cause of death in most cancers, the cellular changes that drive it are poorly understood.

29 Mar 2021

Pfizer-BioNTech vaccine causes steep drop in COVID-19 among healthcare workers

A team of scientists from Spain has recently evaluated the efficacy of an mRNA-based COVID-19 vaccine developed by Pfizer-BioNTech (BNT162b2). Their findings reveal that a 2-dose regimen of BNT162b2 vaccine is capable of providing almost 100% protection against SARS-CoV-2 infection in healthcare workers.

29 Mar 2021

New study provides the most comprehensive reviews of advancements in contact lenses

A newly-published paper represents one of the most comprehensive reviews of advancements to come in contact lenses, catapulting the commonly-used medical device to applications well beyond refractive error correction.

29 Mar 2021

Linear epitope mapping of the SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the primary target of many drug discovery efforts and is similarly utilized in each of the approved COVID-19 vaccines to elicit the generation of anti-spike protein antibodies, thereby granting immunity.

28 Mar 2021

Antibody agents effective at neutralizing European, South African, and United States SARS-CoV-2 variants

Researchers in the United States have demonstrated the effectiveness of three antibody agents at neutralizing recently emerged variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic.

28 Mar 2021

Researchers identify new drug candidates for treating patients with severe COVID-19

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2--the virus that causes COVID-19 - and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects.

27 Mar 2021

Scientists estimate the amount of peanut protein that will elicit an allergic reaction

An estimated 6 million Americans may suffer from peanut allergies. Tiny amounts of peanut protein can lead to hives, itching, tingling in the mouth, shortness of breath or nausea within minutes.

26 Mar 2021

Newly identified pathway controls dangerous overreactions in the body's immune system

Scientists at Sinai Health say they have discovered a new pathway that controls dangerous overreactions in a body's immune system, including deadly forms of hyper-inflammation.

26 Mar 2021

Scientists describe the mechanisms that regulate embryonic stem cells

Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have described the mechanisms, unknown to date, involved in maintaining embryonic stem cells in the best possible state for their use in regenerative medicine.

26 Mar 2021

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

A University of Arizona Health Sciences researcher examined the role of cholesterol in both Alzheimer's disease and Type 2 diabetes to identify a small molecule that may help regulate cholesterol levels in the brain, making it a potential new therapeutic target for Alzheimer's disease.

25 Mar 2021

Study shows substantial benefit of combination therapy for advanced Marburg infections

A new study conducted at the Galveston National Laboratory at the The University of Texas Medical Branch at Galveston has shown substantial benefit to combining monoclonal antibodies and the antiviral remdesivir against advanced Marburg virus.

25 Mar 2021

Repurposed heart and flu drugs that protect platelets improve survival of septic mice

Despite continued improvements in antibiotics and hospital intensive care, staph sepsis - a bloodstream infection caused by Staphylococcus aureus bacteria - still causes severe illness or death in 20 to 30 percent of patients who contract it.

24 Mar 2021

Persistent loneliness during midlife can increase risk of dementia, Alzheimer’s disease

Being persistently lonely during midlife (ages 45-64) appears to make people more likely to develop dementia and Alzheimer's Disease (AD) later in life. However, people who recover from loneliness, appear to be less likely to suffer from dementia, compared to people who have never felt lonely.

24 Mar 2021

Tempus’ ECG Analysis Platform receives Breakthrough Device Designation

Tempus, a leader in artificial intelligence and precision medicine, today announced that the U.S. Food & Drug Administration (FDA) has granted the company Breakthrough Device Designation for its ECG Analysis Platform, developed in collaboration with Geisinger.

24 Mar 2021

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

A new study describes the use of a combination of virtual and experimental screening protocols to identify potential inhibitors of the virus, which could lead to rapid drug development.

24 Mar 2021

Researchers discover a gene mutation linked to schizophrenia

Researchers at The Feinstein Institutes for Medical Research, in collaboration with Columbia University, have identified a gene mutation that could result in schizophrenia, a chronic brain disorder that affects nearly one percent of the world’s population. T

24 Mar 2021

Glycans play a key role in COVID-19 infection, shows study

A research group at the RIKEN Center for Computational Science (R-CCS) has found that glycans—sugar molecules—play an important role in the structural changes that take place when the virus which causes COVID-19 invades human cells.

24 Mar 2021

Potent nanobody binds SARS-CoV-2 spike in an extraordinary manner

In a new study, published recently on the bioRxiv preprint server, researchers isolated a nanobody that potently neutralizes SARS-CoV-2, including the B.1.351 variant, and cross-neutralizes SARS-CoV. They demonstrated the therapeutic potential of the nanobody in a human ACE2 (angiotensin-converting enzyme) transgenic mouse model.

24 Mar 2021

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Previous research identified the interferon-responsive OAS1 gene as a risk gene for Alzheimer's disease. OAS1 is an enzyme that binds to double-stranded RNA and induces the conformation to create oligoadenylates. They also activate RNase L to break down RNA.

23 Mar 2021

Speakers Announced for Virtual Experimental Biology 2021 Meeting

Renowned scientists—including Nobel laureates, research pioneers, and celebrated educators—will speak at the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30.

23 Mar 2021

Therapeutics News and Research

New modeling approach to better understand how tumors become aggressive

Pfizer-BioNTech vaccine causes steep drop in COVID-19 among healthcare workers

New study provides the most comprehensive reviews of advancements in contact lenses

Linear epitope mapping of the SARS-CoV-2 spike protein

Antibody agents effective at neutralizing European, South African, and United States SARS-CoV-2 variants

Researchers identify new drug candidates for treating patients with severe COVID-19

Scientists estimate the amount of peanut protein that will elicit an allergic reaction

Newly identified pathway controls dangerous overreactions in the body's immune system

Scientists describe the mechanisms that regulate embryonic stem cells

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

Study shows substantial benefit of combination therapy for advanced Marburg infections

Repurposed heart and flu drugs that protect platelets improve survival of septic mice

Persistent loneliness during midlife can increase risk of dementia, Alzheimer’s disease

Tempus’ ECG Analysis Platform receives Breakthrough Device Designation

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

Researchers discover a gene mutation linked to schizophrenia

Glycans play a key role in COVID-19 infection, shows study

Potent nanobody binds SARS-CoV-2 spike in an extraordinary manner

Changes in OASI gene expression increases risk of Alzheimer's and severe COVID-19 infection

Speakers Announced for Virtual Experimental Biology 2021 Meeting

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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