Hypoxia News and Research

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Hypoxia is a condition in which there is a decrease in the oxygen supply to a tissue. In cancer treatment, the level of hypoxia in a tumor may help predict the response of the tumor to the treatment.

Research explains why flu is dangerous for pregnant women

A team of researchers at the Royal Melbourne Institute of Technology (RMIT) University explains why flu can lead to potentially fatal complications during pregnancy, suggesting that the virus does not only stay in the respiratory tract but spreads throughout the body.

22 Sep 2020

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Researchers at the University of Cincinnati and UC Health will host a Phase 2 clinical trial (NCT04511650) to examine the effects of a drug that targets blood vessel inflammation and injury in patients with COVID-19.

22 Sep 2020

Seropositive partners increase risk of COVID-19 but not obstetric complications in pregnant women

While earlier studies have shown the significance of serological testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pregnant women, their partners have largely been excluded. Now, a new Danish study published on the preprint server medRxiv in September 2020 reports the impact of serologic testing in both pregnant women and their partners, as well as their newborns.

17 Sep 2020

New research reverses the understanding of kidney tumor growth

Newly published research has reversed our understanding of an aspect of kidney tumor growth. Researchers at Huntsman Cancer Institute at the University of Utah (U of U) discovered that two key proteins have opposite roles than what was previously believed.

12 Sep 2020

Nonharmful stress promotes disease resilience in offspring, shows study

Research led by Jeff Gidday, PhD, Professor of Ophthalmology, Biochemistry, Neuroscience, and Physiology at LSU Health New Orleans School of Medicine, reports what is believed to be the first study in a mammalian model documenting the reprogramming of heritability to promote disease resilience in the next generation.

10 Sep 2020

Risk stratification tool for COVID-19 patients developed

Researchers have worked on the development of a protocol that could stratify COVID-19 patients based on a scoring system. This new study describing the scoring system for risk stratification is titled, “Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score,” and is published in the latest issue of the British Medical Journal.

9 Sep 2020

A global study to determine COVID-19 health and psychosocial consequences

The current paper lays out the details of a longitudinal study that aims to follow up COVID-19 patients, including any pre-existing chronic illnesses as well as the medical care they received during their illness. A significant minority of convalescents appears to have prolonged disease sequelae.

3 Sep 2020

Study: BIRC2 overexpression could be a key marker for immunotherapy resistance

Johns Hopkins Medicine researchers have added to evidence that a gene responsible for turning off a cell's natural "suicide" signals may also be the culprit in making breast cancer and melanoma cells resistant to therapies that use the immune system to fight cancer.

2 Sep 2020

Evidence of SARS-CoV-2 coronavirus particles in heart tissue

Researchers in Milan, Italy, have identified the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the heart tissue of deceased coronavirus disease 2019 (COVID-19) patients who had died from respiratory failure, without showing any signs of cardiac involvement.

27 Aug 2020

Children born at high altitude smaller at birth and have stunted growth

A new study released this week by Ethiopian researchers shows that children who are born at higher altitudes, such as 1,500m (4,921 ft) above sea level, are more at risk of being smaller at birth and have a stunted growth compared to their counterparts born at lower altitudes. The research is published in the latest issue of the journal JAMA Pediatrics.

25 Aug 2020

Living at higher altitudes linked with greater rates of stunting

Residing at higher altitude is associated with greater rates of stunting, even for children living in "ideal-home environments" according to a new study from researchers at the International Food Policy Research Institute and Addis Ababa University.

24 Aug 2020

COVID-19 causes significant dilation of lung blood vessels, indicates study

A new pilot study from the Icahn School of Medicine at Mount Sinai suggests that COVID-19 is causing significant dilation of the blood vessels of the lung, specifically the capillaries.

21 Aug 2020

COVID-19 patients with hypoxia respond positively to a treatment, study shows

Covid-19 patients with hypoxia respond positively to icatibant treatment, Radboud university medical center researchers wrote in JAMA Network Open.

19 Aug 2020

ARDS may not be the primary lung iInjury in COVID-19

A new Italian study published on the preprint server medRxiv in August 2020 shows that this may not be an adequate explanation, since ARDS is a nonspecific diagnosis. Instead, they say, antemortem lung biopsy shows a “Covid pattern” of acute lung injury, which could guide the application of therapeutics.

16 Aug 2020

Cardiovascular disease in COVID-19

The current COVID-19 pandemic is a primarily respiratory illness, manifesting with severe hypoxia and often progressing to acute respiratory distress syndrome (ARDS) and death. However, it is also known to be linked to a wide range of cardiovascular (CV) manifestations that are associated with a very poor prognosis.

13 Aug 2020

Oxygen-deprived breast cancer cells send out messages that promote cancer progression

According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells.

11 Aug 2020

COVID-19 patient with repeatedly undetectable SARS-CoV-2 antibodies

A recent case study published in the Journal of Applied Laboratory Medicine in August 2020 illustrates this with its finding of persistent seronegativity in a patient confirmed to be SARS-CoV-2 positive.

10 Aug 2020

High altitude may act as a protective factor against COVID-19

The analysis by researchers from Spain and Peru reveals that high altitude confers significant protection from coronavirus disease (COVID-19) infection and death – independent of the distance from the pandemic epicenter, population density, or poverty levels. The study is currently available on the medRxiv preprint server.

5 Aug 2020

Lower incidence of COVID-19 in high-altitude residents is intriguing, but requires more research

Despite recent reports of lower COVID-19 incidence among high-altitude populations, current data is insufficient to conclude that high altitude is protective against the SARS-CoV-2 virus, as reported in the peer-reviewed journal High Altitude Medicine & Biology.

4 Aug 2020

Research explains recognized sex differences in COVID-19 outcomes

The COVID-19 pandemic has notably taken a more significant toll on men compared to women, in terms of both disease severity and death. Now, a new study by researchers at the Icahn School of Medicine at Mount Sinai and published on the preprint server medRxiv in August 2020 confirms the increased risk that males have for death following COVID-19 while also highlighting worse outcomes in women with coronary artery disease, obesity, and hypoxia compared to men.

3 Aug 2020