Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Scientists uncover genome variation linked to increased risk of developing Alzheimer's

An article published in Nature Medicine with the collaboration of the research group of Dr. Manel Esteller, director of the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, ICREA Researcher and Professor of Genetics of the University of Barcelona, and Drs. Dave Monk and Isidre Ferrer, from the same center, shows that the inheritance of small changes in DNA alters the expression of the PM20D1 gene and is associated with an increased risk of developing Alzheimer's disease.

14 May 2018

Research may pave way for new C. diff antitoxins and anti-cancer drugs

Researchers from the University of California, Irvine and Harvard University have discovered how the Clostridium difficile toxin B recognizes the human Frizzled protein, the receptor it uses to invade intestinal cells and lead to deadly gastrointestinal infections.

14 May 2018

New study to explore link between diet, intestinal microbiota and cognitive decline

Are abnormal intestinal microorganisms a risk factor for developing cognitive impairment? Researchers at Rush University Medical Center are trying to answer that question with a new study that will explore how the intestinal microbiota – the bacteria in the intestine –influence the progression of cognitive decline and the development of Alzheimer's disease.

14 May 2018

Huron announces collaboration with UPMC and abstract presentation at Pathology Informatics Summit

Huron Digital Pathology announced today that Dr. Hamid Tizhoosh, Director of the KIMIA Lab at the University of Waterloo and Huron advisory board member, will present a talk entitled “Faster, Better, More Reliable than Deep Features: A Projection-Based, Pathologist-Centric Approach to Identification of Histopathology Images” at the Pathology Informatics Summit on May 22, 2018 in Pittsburgh, PA.

From Huron Technologies 11 May 2018

Depleted metabolic enzymes contribute to tumor growth in renal cancer

Kidney cancer, one of the ten most prevalent malignancies in the world, has increased in incidence over the last decade, likely due to rising obesity rates.

10 May 2018

Study: Different strains of same protein may contribute to different Parkinson's-related brain disorders

Different Parkinson's-related brain disorders, called synucleionpathies, are characterized by misfolded proteins embedded in cells.

10 May 2018

ONC201 disrupts mitochondrial function and kills breast cancer cells, reveals study

TRAIL, a member of the TNF family of ligands, causes caspase-dependent apoptosis through activation of its receptors, death receptor 4 and DR5.

9 May 2018

Flushing the bladder with common chemotherapy drug after surgery can reduce bladder cancer recurrence

Flushing the bladder with a common chemotherapy drug immediately after surgery significantly reduces the chances of bladder cancer returning, according to a major study by SWOG, an international clinical trials network funded by the National Cancer Institute.

9 May 2018

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

A new study in Biological Psychiatry reports that dementia-related and psychiatric-related proteins cluster together to form aggregates in the brain, leading to abnormal cell function and behavior.

8 May 2018

Study identifies new biomarker for early lung cancer diagnosis

High levels of cytoskeleton-associated protein 4 (CKAP4) have been identified in the blood of patients with lung cancer.

8 May 2018

Study adds robust evidence to higher prevalence of Alzheimer's among women than men

The APOE gene, the strongest genetic risk factor for Alzheimer's disease, may play a more prominent role in disease development among women than men, according to new research from the Vanderbilt Memory and Alzheimer's Center.

8 May 2018

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center.

8 May 2018

New review of infants with congenital hyperinsulinism shows surgery benefits

A review of nearly 500 cases of infants with severe congenital hyperinsulinism who underwent partial or near-total removal of their pancreas for persistent hypoglycemia at Children's Hospital of Philadelphia showed that surgeons can cure virtually all patients with the focal, or localized, form of the rare genetic disease.

7 May 2018

UTSW study provides insight into potential new therapeutic approaches for skin diseases

Research at UT Southwestern has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excess cell division, known as hyperproliferation.

4 May 2018

Sylentis presents clinical study results of new treatment for dry eye syndrome

Sylentis, Pharmaceutical Company belonging to the PharmaMar Group, has presented results from the clinical studies carried out with tivanisiran for the treatment of dry eye syndrome and that has enabled the start-up of the Phase III "Helix" clinical trial.

3 May 2018

Cancer Center at BIDMC announces launch of new Immunotherapy Institute

The Cancer Center at Beth Israel Deaconess Medical Center today announced the launch of a new clinical and research institute that will build on BIDMC's long history of leadership in immunotherapy and cell therapeutics.

3 May 2018

UCLA researchers report promising drug strategy to block tau transmission

Alzheimer's disease destroys brain cells in part by promoting the formation of insoluble clumps that contain a protein called tau.

3 May 2018

New T cell biomarker could be much-needed patient-selection tool for CAR T cell therapy

Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia don't respond to chimeric antigen receptor T cell therapy, and the answer is tied to how primed patients' immune systems are before the therapy is administered.

30 Apr 2018

New rat models could be useful in the fight against Alzheimer's disease

Alzheimer's disease currently affects more than 5.5 million Americans and is one of the costliest diseases to treat, according to the Alzheimer's Association. Characterized by a buildup of plaque in the brain, few animal models exist that researchers could use to study this devastating disorder.

30 Apr 2018

Tradeshow Talks with Sumo Technologies

In this interview, News-Medical talk to Sumo Technologies about why they are at Health GB this year.

30 Apr 2018

Pathology News and Research

Further Reading

Scientists uncover genome variation linked to increased risk of developing Alzheimer's

Research may pave way for new C. diff antitoxins and anti-cancer drugs

New study to explore link between diet, intestinal microbiota and cognitive decline

Huron announces collaboration with UPMC and abstract presentation at Pathology Informatics Summit

Depleted metabolic enzymes contribute to tumor growth in renal cancer

Study: Different strains of same protein may contribute to different Parkinson's-related brain disorders

ONC201 disrupts mitochondrial function and kills breast cancer cells, reveals study

Flushing the bladder with common chemotherapy drug after surgery can reduce bladder cancer recurrence

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

Study identifies new biomarker for early lung cancer diagnosis

Study adds robust evidence to higher prevalence of Alzheimer's among women than men

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

New review of infants with congenital hyperinsulinism shows surgery benefits

UTSW study provides insight into potential new therapeutic approaches for skin diseases

Sylentis presents clinical study results of new treatment for dry eye syndrome

Cancer Center at BIDMC announces launch of new Immunotherapy Institute

UCLA researchers report promising drug strategy to block tau transmission

New T cell biomarker could be much-needed patient-selection tool for CAR T cell therapy

New rat models could be useful in the fight against Alzheimer's disease

Tradeshow Talks with Sumo Technologies

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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