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PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Researchers show how mutant CALR protein triggers cancer

Researchers at Juntendo University report in the journal Leukemia how mutants of the protein calreticulin lead to molecular mechanisms triggering myeloproliferative neoplasms, which can cause cancer. The findings may lead to the development of novel therapies for certain types of blood cancer.

28 Jun 2018

Novel approach to visualize how platelets are formed in body

Platelets are uniquely mammalian cells, and are the small cells of the blood that are critical for us to stop bleeding when we cut ourselves.

25 Jun 2018

Tiny ultrasound-powered nanorobots could offer safe, efficient way to detoxify biological fluids

Engineers at the University of California San Diego have developed tiny ultrasound-powered robots that can swim through blood, removing harmful bacteria along with the toxins they produce. These proof-of-concept nanorobots could one day offer a safe and efficient way to detoxify and decontaminate biological fluids.

31 May 2018

Researchers develop injectable bandage to stop fatal blood loss, activate wound healing

While several products are available to quickly seal surface wounds, rapidly stopping fatal internal bleeding has proven more difficult.

22 May 2018

FDA approves new drug to treat thrombocytopenia in adults with chronic liver disease

The U.S. Food and Drug Administration today approved Doptelet (avatrombopag) tablets to treat low blood platelet count (thrombocytopenia) in adults with chronic liver disease who are scheduled to undergo a medical or dental procedure. This is the first drug approved by the FDA for this use.

22 May 2018

Drug combination may prevent secondary stroke in certain patients, study shows

Results from an international clinical trial of more than 4880 participants, published in the New England Journal of Medicine, show that combining clopidogrel and aspirin following a small stroke or experiencing minor stroke symptoms decreases risk of a new stroke, heart attack or other ischemic event within 90 days.

17 May 2018

Scientists reveal active role of IgG antibodies in severity of anaphylaxis

The most severe allergic reaction, anaphylaxis, is the result of an inappropriate immune reaction following the introduction of a usually harmless antigen into the body.

16 May 2018

New findings point to potential therapeutic avenues for leukemia

Scientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia.

9 May 2018

Hollings Cancer Center immunologist inducted into Association of American Physicians

Physician scientist and Hollings Cancer Center immunologist Zihai Li, M.D., Ph.D., was inducted into the Association of American Physicians.

28 Apr 2018

Cancer risk found to be three times greater after acute thrombosis in the leg

Patients with the most acute type of thrombosis in the leg - known as an arterial thrombosis - risk developing diseases that are far worse than the blood clot itself. The risk of developing cancer during the first six months after the blood clot is three times greater than normal.

16 Apr 2018

Experimental peptide drug shows promise against acute myeloid leukemia

In a study published online today in Science Translational Medicine, Albert Einstein College of Medicine researchers report that an experimental peptide drug shows promise against the often-lethal cancer acute myeloid leukemia and describe how the drug works at the molecular level.

11 Apr 2018

Researchers reveal new tactic to fight antibiotic-resistant pneumonia

Antibiotic resistance is a growing threat in bacterial pneumonia. While immune-stimulating treatments can help the body kill the bacteria, they can also cause inflammation that damages and weakens lung tissue. Researchers at Boston Children's Hospital now describe an approach that offers the best of both worlds: enhanced bacterial killing with reduced lung damage.

4 Apr 2018

Researchers fabricate injectable bandage to promote wound healing

A penetrating injury from shrapnel is a serious obstacle in overcoming battlefield wounds that can ultimately lead to death.Given the high mortality rates due to hemorrhaging, there is an unmet need to quickly self-administer materials that prevent fatality due to excessive blood loss.

3 Apr 2018

FDA grants accelerated approval to leukemia drug for patients with MRD-positive ALL

The U.S. Food and Drug Administration granted accelerated approval to Blincyto (blinatumomab) to treat adults and children with B-cell precursor acute lymphoblastic leukemia (ALL) who are in remission but still have minimal residual disease (MRD).

30 Mar 2018

Blood donor scraps help researchers to discover new insight into human immune system

Iowa State University researchers have discovered new insight into the human immune system from an unlikely source, the leftover material from blood donation banks.

16 Mar 2018

Blood flow defies the laws of fluid dynamics

Researchers have developed a 3D simulation of blood cells travelling through realistic microvascular networks that has predicted several novel phenomena.

16 Mar 2018

Lower levels of protective molecules could increase heart attack risk in the morning

Cardiovascular disease patients have lower levels of an important family of protective molecules in their blood in the morning, which could be increasing their risk of blood clots and heart attacks at those times, according to early research led by Queen Mary University of London.

9 Mar 2018

Aspirin appears to reduce risk of death, hospitalization for people with heart failure and diabetes

For people living with both Type 2 diabetes and heart failure, taking an aspirin each day appears to lower the risk of dying or being hospitalized for heart failure, according to research being presented at the American College of Cardiology's 67th Annual Scientific Session.

28 Feb 2018

Russian researchers develop new multi-layered biodegradable scaffolds

A team of young researchers at the National University of Science and Technology has recently presented its new development – therapeutic material based on nanofibers of polycaprolactone, modified with plasma-deposited thin layers enriched with antibacterial composition and human blood plasma components.

19 Feb 2018