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What makes H5N1 a pandemic risk and how can we stop it?

A new PEARLS article in PLoS Pathogens reviews the rapid evolution and pandemic potential of emerging influenza A viruses, with a focus on H5N1. It highlights scientific advances and future strategies to outpace the virus, from next-generation vaccines to AI-driven antiviral discovery.

19 May 2025

Targeting cGAS shows promise for treating cardiac dysfunction after cardiac arrest

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac dysfunction is a prevalent and serious complication after cardiac arrest (CA), yet limited therapeutic interventions are available.

19 May 2025

Electromagnetic waves disrupt SARS-CoV-2 spike protein and lower infectivity

Researchers demonstrated that specific electromagnetic wave frequencies can disrupt the SARS-CoV-2 Spike protein structure in virus-like particles, leading to reduced infectivity in cell models. This proof-of-concept study suggests new avenues for non-chemical viral inactivation methods.

18 May 2025

Customized CRISPR gene editing therapy successfully treats infant with rare disease

In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children's Hospital of Philadelphia (CHOP) and Penn Medicine.

15 May 2025

TMEM219 inhibition shows promise in restoring intestinal health in IBD

An international study led by Paolo Fiorina from Boston Children's Hospital and in collaboration with researchers from University of Milan highlights the beneficial effect of inhibiting the death receptor TMEM219 to restore mucosal healing in inflammatory bowel diseases.

15 May 2025

Once-daily oral treatment shows positive results in first human study for obesity treatment

A first-in-human study of an investigational once-daily oral treatment for obesity (SYNT-101) demonstrated positive preliminary data for the safe and effective redirection of nutrient absorption into the lower intestine, the weight loss and metabolic management mechanism behind gastric bypass surgery.

14 May 2025

New light-based 3D printing technique advances tissue engineering

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering.

13 May 2025

New study identifies wedelolactone as a potent topical treatment for psoriasis

Announcing a new publication for Acta Materia Medica journal. Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways.

13 May 2025

MicroRNA breakthrough offers hope for dental bone regeneration

Dental caries, or tooth decay, is a common oral health condition that often causes significant pain and discomfort and may even lead to tooth loss.

8 May 2025

Study identifies key enzyme linked to metastasis in head and neck cancer

A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC).

8 May 2025

Study uncovers how co-infection by two bacteria suppresses immune response

The incidence of infection by Mycobacterium abscessus, is increasing in patients with cystic fibrosis, chronic obstructive pulmonary disease (COPD), and other chronic pulmonary diseases, leading to an accelerated lung function decline.

8 May 2025

New insights into bacterial division through engineered protein control

The Min protein system prevents abnormal cell division in bacteria by forming oscillating patterns between the ends of a cell ("poles"). Despite decades of theoretical work, predicting the protein concentrations at which oscillations start and whether cells can maintain them under different conditions has been a challenge.

7 May 2025

Precision medicine approach improves treatment for soft tissue sarcomas

A study conducted by researchers from the Agency for Science, Technology and Research (A*STAR), National Cancer Centre Singapore (NCCS) and National University of Singapore (NUS), in collaboration with biotech company, KYAN Technologies, has demonstrated that a precision medicine approach improves treatment selection for patients with soft tissue sarcomas (STS) in a clinical setting.

7 May 2025

New hybrid technology enhances precision in stem cell therapy for brain diseases

Neurodegenerative diseases like Parkinson's and Alzheimer's are characterized by irreversible neuron damage and limited natural repair mechanisms.

6 May 2025

Scientists engineer new drug candidate to fight deadly mycobacterial infection

In a classic example of scientific problem solving, scientists from the Hackensack Meridian Center for Discovery and Innovation (CDI) and colleagues have published a paper introducing a promising new drug candidate they engineered to target a deadly and emerging infection.

6 May 2025