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Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

A research group from Harvard Medical School reported two cryo-electron microscopy structures derived from a single preparation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in their paper available on the preprint server bioRxiv. Understanding the nuances of prefusion and postfusion conformations shed light on viral cell entry and may, in turn, guide the development of vaccines and drugs.

18 May 2020

University of Valencia files patent application for COVID-19 vaccine

The University of Valencia has filed a patent application for a vaccine candidate against COVID-19, developed by a research team from the Department of Microbiology

18 May 2020

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

18 May 2020

Takeda to present oncology pipeline data at upcoming virtual scientific congresses

Takeda Pharmaceutical Company Limited today announced that the company will present data from its expanding oncology pipeline and established product portfolio at two upcoming virtual scientific congresses: the 56th Annual Meeting of the American Society of Clinical Oncology, May 29-31 and the 25th Virtual Congress of the European Hematology Association, June 11-14.

18 May 2020

Host-virus interaction drives adaptive mutation in bat CoV related to SARS-CoVs

Virus and receptor diversity is shaped by the need to evolve advanced weaponry to facilitate virus entry and infection, on the one hand, and host resistance, on the other. A new paper published on the preprint server bioRxiv* shows how this mechanism operates in a bat coronavirus, which is related to the earlier SARS coronavirus.

17 May 2020

Inadequate vaccine and epidemic control in the US

A new paper published on the preprint server medRxiv* in May 2020 shows that vaccination must be combined with nonpharmacological interventions (NPIs) to achieve rapid and effective control of the ongoing pandemic.

17 May 2020

New and unexplored angle in the binding of SARS-CoV-2 to host cells

Researchers in the Netherlands, Cuba, and Italy have made important discoveries about the carbohydrate-mediated binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to host cell lectin receptors and host lung microbiota.

17 May 2020

Well-known cancer drugs may prevent SARS-CoV-2 viral replication say researchers

Researchers in Frankfurt, Germany, have described cell signaling events that occur when severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells and have identified pathways that are essential for the virus to replicate.

17 May 2020

Interdisciplinary team to develop a new physics-based technology for COVID-19 detection

One of the most challenging aspects of the COVID-19 pandemic has been the lack of testing needed to detect and trace infections--and without adequate testing, government officials do not have the data they need to make the best possible decisions in the interest of public health.

15 May 2020

Boehringer Ingelheim partners with CDR-Life to develop antibody fragment-based therapeutics for geographic atrophy

Boehringer Ingelheim and CDR-Life today announced they have entered into a collaboration and licensing agreement to research and develop antibody fragment-based therapeutics for geographic atrophy (GA).

From Boehringer Ingelheim International GmbH 15 May 2020

Importance of detecting neutralizing antibody response in recovered COVID-19 patients

In an article published today in Cell Host and Microbe, Professor Kanta Subbarao stressed the importance of detecting a neutralizing antibody response in recovered COVID-19 patients, and of studies of COVID-19 vaccines in animal models.

15 May 2020

11 healthcare centers participate in clinical trial of Russian drug against novel coronavirus

Initially, the drug was developed to treat rheumatoid arthritis. BIOCAD developers receive regulatory authorization as part of the procedure approved by Decree No. 441 of the Government of the Russian Federation of April 4, 2020 since the mechanism of action of the active substance is associated with the cytokine storm, a life-threatening immune system response in patients with COVID-19.

14 May 2020

Researchers develop the most sensitive bioelectronic ammonia gas sensors

Writing in the journal NanoResearch, a team at the University of Massachusetts Amherst reports this week that they have developed bioelectronic ammonia gas sensors that are among the most sensitive ever made.

14 May 2020

Researchers make a significant leap in mucus biology

Worldwide, hundreds of millions of people are impacted by chronic respiratory disease. COPD alone affects more than 250 million people, causing 3 million deaths each year.

13 May 2020

Processes underlying the damaging effects of brain injury can preserve memory function

A study examining the effect of the immune receptor known as Toll-like Receptor 4, or TLR4, on how memory functions in both the normal and injured brain has found vastly different cellular pathways contribute to the receptor's effects on excitability in the uninjured and injured brain.

13 May 2020

Nanosized silver cubes can make it easier to read diagnostic tests

Engineers at Duke University have shown that nanosized silver cubes can make diagnostic tests that rely on fluorescence easier to read by making them more than 150 times brighter.

13 May 2020

Optibrium’s StarDrop now powered by OpenEye Scientific’s cheminformatics toolkits

Optibrium and OpenEye Scientific, leading providers of software and services for drug discovery, today announced that StarDrop, Optibrium’s software for small molecule design, optimization and data analysis, is now powered by OpenEye Scientific’s cheminformatics toolkits.

From Optibrium Ltd. 13 May 2020

New rapid CRISPR-based test for sensitive SARS-CoV-2 detection

A new study reports the approval of a new CRISPR-based coronavirus test that is both sensitive and rapid and intended to help reduce the time required to test symptomatic or potentially contagious cases.

13 May 2020

Innovative approach turns 'cold' tumors 'hot' to improve cancer immunotherapy

Scientists from the Tumor Immunotherapy and Microenvironment research group led by Dr Bassam Janji at the Luxembourg Institute of Health Department of Oncology, and the Swedish pharma company Sprint Bioscience published the results of an innovative approach that turns “cold” tumors “hot”. “Cold”, immune-desert tumors are classically immunotherapy-resistant.

13 May 2020

New method allows researchers to guide neurons in 3D

Highly complex organisms can arise from a single cell, which is one of the true miracles of nature. Substances known as morphogens have an important role in this development, namely by signalling to cells where they should go and what they should do.

13 May 2020

Molecule News and Research

Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

University of Valencia files patent application for COVID-19 vaccine

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

Takeda to present oncology pipeline data at upcoming virtual scientific congresses

Host-virus interaction drives adaptive mutation in bat CoV related to SARS-CoVs

Inadequate vaccine and epidemic control in the US

New and unexplored angle in the binding of SARS-CoV-2 to host cells

Well-known cancer drugs may prevent SARS-CoV-2 viral replication say researchers

Interdisciplinary team to develop a new physics-based technology for COVID-19 detection

Boehringer Ingelheim partners with CDR-Life to develop antibody fragment-based therapeutics for geographic atrophy

Importance of detecting neutralizing antibody response in recovered COVID-19 patients

11 healthcare centers participate in clinical trial of Russian drug against novel coronavirus

Researchers develop the most sensitive bioelectronic ammonia gas sensors

Researchers make a significant leap in mucus biology

Processes underlying the damaging effects of brain injury can preserve memory function

Nanosized silver cubes can make it easier to read diagnostic tests

Optibrium’s StarDrop now powered by OpenEye Scientific’s cheminformatics toolkits

New rapid CRISPR-based test for sensitive SARS-CoV-2 detection

Innovative approach turns 'cold' tumors 'hot' to improve cancer immunotherapy

New method allows researchers to guide neurons in 3D

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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