Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Dr. Sharma receives research award from ASCO to continue study on triple-negative breast cancer

Dr. Sharma was awarded the 2015 Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology to continue her research on triple-negative breast cancer.

25 Aug 2015

Discovery could influence future research on respiratory failure associated with diabetes

Previous studies have shown that diabetes adversely affects breathing and respiratory function. However, in the past, researchers have not differentiated diaphragm muscle cells and the muscle cells of limb skeletal muscle in their studies. Now, researchers from the University of Missouri have found that diaphragm muscle cells and other skeletal muscle cells behave differently--a finding that could influence future research on respiratory ailments associated with diabetes.

20 Aug 2015

Researchers uncover genetic circuit involved in obesity

Like many other conditions, obesity is caused by an interplay between genetic and environmental factors. While efforts to combat the obesity epidemic will need to include changes in diet and exercise, insights into the genes involved may also help with prevention and treatment.

20 Aug 2015

Complete removal of visible tumor improves outcomes in children with high-grade glioma

For children with aggressive brain cancers called high-grade gliomas (HGG), the chances of survival are improved when surgery is successful in eliminating all visible cancer, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

19 Aug 2015

IDT webinar explores effective RNAi and antisense oligo methods

Integrated DNA Technologies (IDT) will host an informative webinar, entitled ‘Knockdown of lncRNAs: exploring RNAi and antisense oligo methods’, on Tuesday, August 25, 2015. Kim Lennox, a research scientist at IDT and expert in the suppression of gene expression, will present the webinar at 9 am and 1 pm Central Standard Time.

From Integrated DNA Technologies 19 Aug 2015

Researchers reveal cellular origin of PIK3CA-induced breast tumors

In a study published in Nature, researchers lead by Cédric Blanpain, MD/PhD, WELBIO investigator and Professor at the Université libre de Bruxelles, Belgium, in collaboration with Pr Wayne Phillips, Australia and Pr Christos Sotiriou, Bordet Institute, Belgium, uncovered the cellular origin of PIK3CA-induced breast tumors and demonstrated that the cancer cell of origin controls tumor heterogeneity and is associated with different breast tumors types and clinical prognosis.

13 Aug 2015

Researchers develop user-friendly platform for analyzing transcriptomic and epigenomic big data

Researchers at Cincinnati Children's Hospital Medical Center have developed a user-friendly, integrated platform for analyzing the transcriptomic and epigenomic "big data."

12 Aug 2015

Researcher study potential biomarker to determine patients at risk for aggressive breast cancer

Biomarkers are an important part in detecting certain cancers such as the BRCA gene in breast cancer and the PSA antigen in prostate cancer. They are easy to identify in a blood test and can help in diagnosing and giving a prognosis.

12 Aug 2015

Embryonic stem cells may help researchers to study physiological effects of environmental pollutants on human health

A recent study published in the Journal of Environmental Sciences shows that embryonic stem cells could serve as a model to evaluate the physiological effects of environmental pollutants efficiently and cost-effectively.

11 Aug 2015

Researchers report role of two gene-regulating molecules in Parkinson's disease

As Parkinson's disease progresses in patients, a puzzling dichotomy plays out in their brains. One set of neurons degenerates, while a similar population nearby is spared the same degree of damage. Why the difference? An answer to this question could clear the way for preventions and treatments for this disease, which impairs movement.

11 Aug 2015

PrediXcan method improves detection of genes linked to complex diseases, biological traits of interest

A new computational method developed by scientists from the University of Chicago improves the detection of genes that are likely to be causal for complex diseases and biological traits. The method, PrediXcan, estimates gene expression levels across the whole genome - a better measure of biological action than single mutations - and integrates it with genome-wide association study (GWAS) data.

11 Aug 2015

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal, healthy growth, with vital instructions being passed on from cell to cell by a process known as mitosis. While this copying mechanism has been well understood for decades, scientists have been unable to describe exactly how genetic information is protected and properly segregated as mitosis is happening.

7 Aug 2015

Penn research reveals additional pathway for origin of colon cancer

Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don't yet have the full picture of how these cancers originate and spread. Now researchers from the Perelman School of Medicine at the University of Pennsylvania have illuminated another powerful factor in this process.

6 Aug 2015

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

Since the classical studies of Jacob and Monod in the early 1960s, it has been evident that genome sequences contain not only blueprints for genes and the proteins that they encode, but also the instructions for a coordinated regulatory program that governs when, where and to what extent these genes and proteins are expressed.

4 Aug 2015

MD Anderson scientists reveal role of metabolic enzyme fumarase in DNA repair

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks can be repaired.

4 Aug 2015

First biodegradable gene delivery system efficiently penetrates human airway mucus barrier of lung tissue

Researchers at the Johns Hopkins University School of Medicine, Johns Hopkins University Department of Chemical and Biomolecular Engineering, and Federal University of Rio de Janeiro in Brazil have designed a DNA-loaded nanoparticle that can pass through the mucus barrier covering conducting airways of lung tissue — proving the concept, they say, that therapeutic genes may one day be delivered directly to the lungs to the levels sufficient to treat cystic fibrosis (CF), chronic obstructive pulmonary disease, asthma and other life-threatening lung diseases.

4 Aug 2015

RNA-binding protein ROQUIN regulates response to DNA damage

Messenger (mRNA) molecules are a key component of protein biosynthesis. They are first transcribed as a "working copy" of the DNA and then translated into protein molecules.

3 Aug 2015

BUSM researchers find new way to detect and treat basal-like breast cancer

A new way to detect - and perhaps treat - one of the deadliest types of breast cancer has been found. Led by researchers at Boston University School of Medicine (BUSM), the study appears online in Breast Cancer Research.

3 Aug 2015

FDA accepts Mundipharma EDO's Investigational New Drug Application for EDO-S101

Mundipharma EDO GmbH (Early Development in Oncology) is pleased to announce that the United States Food and Drug Administration has accepted the company's Investigational New Drug Application ("IND") for EDO-S101, a fusion molecule to treat relapsed/refractory haematologic malignancies and solid tumours.

31 Jul 2015

Reducing incorrect gene expression can extend lifespan of cells

Working with yeast and worms, researchers found that incorrect gene expression is a hallmark of aged cells and that reducing such "noise" extends lifespan in these organisms. The team published their findings this month in Genes & Development.

31 Jul 2015

Gene Expression News and Research

Further Reading

Dr. Sharma receives research award from ASCO to continue study on triple-negative breast cancer

Discovery could influence future research on respiratory failure associated with diabetes

Researchers uncover genetic circuit involved in obesity

Complete removal of visible tumor improves outcomes in children with high-grade glioma

IDT webinar explores effective RNAi and antisense oligo methods

Researchers reveal cellular origin of PIK3CA-induced breast tumors

Researchers develop user-friendly platform for analyzing transcriptomic and epigenomic big data

Researcher study potential biomarker to determine patients at risk for aggressive breast cancer

Embryonic stem cells may help researchers to study physiological effects of environmental pollutants on human health

Researchers report role of two gene-regulating molecules in Parkinson's disease

PrediXcan method improves detection of genes linked to complex diseases, biological traits of interest

Researchers identify genome-organizing mechanism that transmits vital genetic materials during mitosis

Penn research reveals additional pathway for origin of colon cancer

Research: Critical aspects of human genome's regulatory program encoded by genomic sequence elements

MD Anderson scientists reveal role of metabolic enzyme fumarase in DNA repair

First biodegradable gene delivery system efficiently penetrates human airway mucus barrier of lung tissue

RNA-binding protein ROQUIN regulates response to DNA damage

BUSM researchers find new way to detect and treat basal-like breast cancer

FDA accepts Mundipharma EDO's Investigational New Drug Application for EDO-S101

Reducing incorrect gene expression can extend lifespan of cells

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