Therapeutics News and Research

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New biomarker of Alzheimer's may lead to enhanced diagnostic methods

Scientists at Washington University School of Medicine, Missouri, have identified a novel form of an Alzheimer’s protein in the spinal fluid of patients.

7 Dec 2020

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Researchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's disease (AD) that could lead to therapies focused on treating the neurodegenerative condition early in its progression.

7 Dec 2020

Researchers shed light on the role of antibodies and immune cells in protection against COVID-19

Since the novel coronavirus emerged at the end of last year, scientists around the world -- including Beth Israel Deaconess Medical Center (BIDMC) immunologist Dan Barouch, MD, PhD -- have been developing vaccines to protect against COVID-19 and to put an end to the global pandemic.

5 Dec 2020

Clinical metagenomics, a faster approach to identify secondary infections in hospitalized COVID-19 patients

Scientists have demonstrated that clinical metagenomic detection of microbial communities can improve the management of infections in COVID-19 patients.

4 Dec 2020

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

A group of researchers developed a promising fix to CRISPR-Cas9's problem with unwanted genetic changes using a method that allows them to turn off gene-editing until it reaches key cell cycle phases where more accurate repairs are likely to happen.

4 Dec 2020

Study provides detailed view of the brain’s ventral striatum activity involved in decision-making

Neuroscientists have provided clear visual evidence that a region of the human brain known as the ventral striatum kicks in during decision-making to weigh the costs versus the benefits of making a physical effort.

4 Dec 2020

International scientific team reports 'super-spreader' potential of Andes virus

"Super-spreader" events and extensive person-to-person contact propelled an outbreak of hantavirus pulmonary syndrome in a small village in Argentina from 2018-2019, according to research published today in The New England Journal of Medicine.

3 Dec 2020

TTUHSC professor receives 2020 Lupus Mechanisms and Targets Award

The Lupus Research Alliance recently named R. Bryan Sutton, Ph.D., a professor in the Department of Cell Physiology and Molecular Biophysics at the Texas Tech University Health Sciences Center, as a recipient of a 2020 Lupus Mechanisms and Targets Award.

3 Dec 2020

Researchers uncover potential glycine-based treatment for NAFLD

A new study further implicates low levels of the amino acid glycine in development of nonalcoholic fatty liver disease, or NAFLD. It also suggests addressing this might hold the key to a future treatment for the disease.

3 Dec 2020

New insight into role of autophagy in controlling SARS-CoV-2 infection

A team of researchers at the University of Manitoba in Canada said that nanoparticle targeting of autophagy at the sites could be a potent tool to effectively overcome COVID-19 while preventing the common adverse effects of the drug.

2 Dec 2020

Surprising discovery reveals new target for aggressive lung adenocarcinoma

Targeted therapies are currently available for about one-third of people with lung adenocarcinoma, the most common kind of lung cancer.

2 Dec 2020

Spanish-originated SARS-CoV-2 variant A222V shows rapid spread in Lazio, Italy

A startling new study reports the rapid rise to dominance of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain in Italy. This strain, termed the GV clade, is characterized by a single point mutation.

2 Dec 2020

Genethon to start international clinical trial for treatment of Duchenne muscular dystrophy

Genethon, dedicated to designing and developing gene therapy products for rare diseases, received this Monday 30th of November the authorization from the ANSM, the French National Agency for Medicines and Health Products Safety, to start in France a multicentre international clinical trial for the treatment of Duchenne muscular dystrophy with product GNT 004.

2 Dec 2020

Study: Tumors with high TMB tend to respond better to immune checkpoint inhibitors

Treatments that harness the immune system to fight cancer have greatly improved outcomes for some people with cancer. Scientists are learning more about why some people respond much better than others to these drugs.

2 Dec 2020

Improved understanding of exposome-drug interactions could help prescribe effective drug doses

According to scientific estimations, humans are exposed to at least 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime, which are mainly absorbed through our dietary.

2 Dec 2020

Researchers develop telomerase gene therapy for treating different pathologies

After several years of research and many joint scientific publications, molecular biologists Maria Blasco (National Cancer Research Centre, CNIO) and Fàtima Bosch (Universitat Autònoma de Barcelona, UAB) have developed a telomerase gene therapy for the treatment of different pathologies related to shortening telomeres and, therefore, ageing.

2 Dec 2020

‘Artificial Pancreas Dashboard' can help standardize hybrid closed-loop reporting

A standardized "Artificial Pancreas (AP) Dashboard" should provide easy to use single-page hybrid closed-loop system (HCL) reporting for insulin requiring patients with diabetes.

2 Dec 2020

UCLA, UCSF obtain FDA approval for PSMA PET imaging in men with prostate cancer

The University of California's two nationally ranked medical centers, UCSF and UCLA, and their nuclear medicine teams have obtained approval from the U.S. Food and Drug Administration to offer a new imaging technique for prostate cancer that locates cancer lesions in the pelvic area and other parts of the body to which the tumors have migrated.

2 Dec 2020

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

In an article published in the journal Virus Research, a team of researchers from various US institutions discussed their study that evaluated the antiviral activity of PTC299 against a group of RNA viruses in vitro.

1 Dec 2020

OHDSI awarded $10 million FDA contract to support Biologics Effectiveness and Safety program

Researchers within the Observational Health Data Services and Informatics (OHDSI) community were recently awarded a $10 million contract from the U.S. Food and Drug Administration (FDA) to provide support to the Biologics Effectiveness and Safety (BEST) program, which was launched by the FDA Center for Biologics Evaluation and Research (CBER) in 2017.

1 Dec 2020

Therapeutics News and Research

New biomarker of Alzheimer's may lead to enhanced diagnostic methods

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Researchers shed light on the role of antibodies and immune cells in protection against COVID-19

Clinical metagenomics, a faster approach to identify secondary infections in hospitalized COVID-19 patients

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

Study provides detailed view of the brain’s ventral striatum activity involved in decision-making

International scientific team reports 'super-spreader' potential of Andes virus

TTUHSC professor receives 2020 Lupus Mechanisms and Targets Award

Researchers uncover potential glycine-based treatment for NAFLD

New insight into role of autophagy in controlling SARS-CoV-2 infection

Surprising discovery reveals new target for aggressive lung adenocarcinoma

Spanish-originated SARS-CoV-2 variant A222V shows rapid spread in Lazio, Italy

Genethon to start international clinical trial for treatment of Duchenne muscular dystrophy

Study: Tumors with high TMB tend to respond better to immune checkpoint inhibitors

Improved understanding of exposome-drug interactions could help prescribe effective drug doses

Researchers develop telomerase gene therapy for treating different pathologies

‘Artificial Pancreas Dashboard' can help standardize hybrid closed-loop reporting

UCLA, UCSF obtain FDA approval for PSMA PET imaging in men with prostate cancer

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

OHDSI awarded $10 million FDA contract to support Biologics Effectiveness and Safety program

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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