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Indian SARS-CoV-2 variant shows enhanced host cell entry and immune evasion

A study conducted by researchers in Germany has found that the B.1.617 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has emerged in India entered certain types of lung and intestine cells with slightly increased efficiency compared with the original wild-type strain.

6 May 2021

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn's disease in a flagellin peptide-specific immunotherapy.

6 May 2021

Study reveals a new form of muscular dystrophy associated with pathogenic changes in JAG2 gene

In about a quarter of patients with hereditary diseases, the cause of the disease remains unclear even after extensive genetic testing. One reason is that we still do not know enough about the function of many genes. Of the 30,000 known genes, just a little more than 4,000 have been found to be associated with hereditary diseases.

6 May 2021

Monocytes promote viral control during SARS-COV-2 infection

In a paper recently uploaded to the preprint server bioRxiv by Vanderheiden et al. (May 4th, 2021) the contribution of monocytes in promoting protective immunity from SARS-CoV-2 is investigated in a murine model, suggesting that CCR2 plays the role of an inflammation modulator in early infection.

6 May 2021

Novel pipeline identifies millions of molecular targets in SARS-CoV-2

Researchers in the United States have developed a novel pipeline for high-throughput, automated annotation of the genes, proteins and functional domains in the genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

5 May 2021

New genetic mutation increases risk for atrial fibrillation, heart failure in Black people

A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.

5 May 2021

New $10.7 million project aims to study the genetic underpinnings of Alzheimer's disease

Despite decades of research and investment, the genetic underpinnings of Alzheimer's disease are still largely unknown, stymieing drug development and early diagnosis efforts.

5 May 2021

Stem cell therapy for COVID-19 and ARDS

In a review paper recently uploaded to the journal Biomedicine & Pharmacotherapy by Mahendiratta et al. (May 2021) the applicability of stem cells in treating severe SARS-CoV-2 infection is investigated, with regard to ARDS therapy.

5 May 2021

Penn State researchers develop a way to study microenvironment of breast cancer in 3D

Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells.

4 May 2021

Scientists identify genetic mutation associated with exfoliation syndrome known to cause glaucoma

A team of researchers from the Agency for Science, Technology and Research's Genome Institute of Singapore and Bioprocessing Technology Institute, as well as Singapore Eye Research Institute, have identified a genetic mutation (functionally defective CYP39A1 gene) associated with exfoliation syndrome, the most common cause of glaucoma.

4 May 2021

Researchers develop new technology to reduce high error rates in gene sequencing

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream.

4 May 2021

Proteomic and transcriptomic profiling provide a full picture of aging process in the kidneys

Studying protein changes in the kidneys as we age, as well as the transcription of genes into proteins, helps provide a full picture of the age-related processes that take place in these organs, says a study in mice published today in eLife.

4 May 2021

Unique system detects small changes in DNA structures

Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now.

4 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

In a paper recently uploaded to the preprint server medRxiv by Edward Málaga Trillo et al. (April 29th, 2021), these methods are tested in combination with CRISPR-Cas detection in the field, demonstrating a sensitivity and specificity of 93.8% and 99%, respectively.

4 May 2021

SARS-CoV-2 study in human gut organoids

Most of the major life-threatening symptoms of COVID-19 disease are associated with the host's generation of an exacerbated pro-inflammatory immune response. Many studies have correlated the intensity of the immune response with the severity of disease.

3 May 2021

Differential NK cell activity found to contribute to SARS-CoV-2 infection resistance

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide and is the leading cause of mortality in Brazil in 2020 as well as early 2021. Clinical manifestations of COVID-19 disease range from no symptoms and mild flu-like symptoms to severe cases leading to hospitalization and death.

3 May 2021

Genome News and Research

Indian SARS-CoV-2 variant shows enhanced host cell entry and immune evasion

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Study reveals a new form of muscular dystrophy associated with pathogenic changes in JAG2 gene

Monocytes promote viral control during SARS-COV-2 infection

Novel pipeline identifies millions of molecular targets in SARS-CoV-2

New genetic mutation increases risk for atrial fibrillation, heart failure in Black people

New $10.7 million project aims to study the genetic underpinnings of Alzheimer's disease

Stem cell therapy for COVID-19 and ARDS

Penn State researchers develop a way to study microenvironment of breast cancer in 3D

Scientists identify genetic mutation associated with exfoliation syndrome known to cause glaucoma

Researchers develop new technology to reduce high error rates in gene sequencing

Proteomic and transcriptomic profiling provide a full picture of aging process in the kidneys

Unique system detects small changes in DNA structures

Four-part small-molecule cocktail can prevent cellular stress

Rapid and sensitive SARS-CoV-2 detection from saliva using CRISPR

SARS-CoV-2 study in human gut organoids

Differential NK cell activity found to contribute to SARS-CoV-2 infection resistance

Designing effective multidrug-resistant-TB treatments based on DNA sequencing

COVID-19 may not have appeared first in China, suggests new genomic study

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

Genetics & Genomics - Second Edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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