Efficacy News and Research

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Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

A new study reviews recent advancements made in the development of RSV immunoprophylactic measures.

11 Aug 2022

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Researchers investigated the susceptibility of naturally-occurring severe acute respiratory syndrome coronavirus 2 main protease variants to protease inhibitor drugs, including nirmatrelvir and ensitrelvir.

11 Aug 2022

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

Researchers demonstrated multiple routes SARS-CoV-2 might take to develop high-level resistance to nirmatrelvir, an oral antiviral targeting the 3C-like protease (3CLpro) of SARS-CoV-2.

11 Aug 2022

OICR funding to help five research projects take the next step toward advancing cancer care

Five Ontario-based research projects will take the next step toward advancing cancer care in the province thanks to funding from the Ontario Institute for Cancer Research (OICR).

11 Aug 2022

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Researchers described a novel protein subunit vaccine comprising the receptor-binding domain (RBD) of ancestral SARS-CoV-2 spike (S) protein, dimerized with an immunoglobulin (Ig)G1-fraction, crystallizable (Fc) domain.

11 Aug 2022

COVID-19 infection in pregnant women linked to increased risk of adverse outcomes

COVID-19 infection in pregnant women is associated with increased risk of adverse outcomes compared to women who are not pregnant, according to a review published in JACC: Advances from the American College of Cardiology Cardiovascular Disease in Women Committee.

11 Aug 2022

Azelastine nasal spray could decrease SARS-CoV-2 load

A new study illustrated that early azelastine nasal spray therapy might lower the SARS-CoV-2 load among virus-infected patients.

11 Aug 2022

Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies

In a recent Biomaterials study, researchers developed AIEgen-embedded polystyrene (PS) nanoparticles-based LFIA that can accurately detect anti-SARS-CoV-2 NAb in serum samples of vaccinated individuals.

11 Aug 2022

Scientists develop nanoantidote to reduce acidosis in critically ill COVID-19 patients

A group of scientists from China has recently developed an antacid nanoantidote that can effectively ameliorate blood acidosis induced by SARS-CoV-2 infection.

11 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

New compound proves to be potent against more than 300 drug-resistant bacteria

Urinary tract infections are common, yet are increasingly tough to treat because the bacteria that cause them are becoming resistant to many antibiotics.

10 Aug 2022

Research may lead the way to a simpler treatment for cancer

Sometimes too much of a good thing is not good at all. Inhibiting the function of the PD-1 protein, which blocks immune function, has shown high therapeutic efficacy in cancer immunotherapy.

10 Aug 2022

Review of natural products with promising anti-SARS-CoV-2 potential

In a new study, researchers reviewed existing literature on naturally active products with therapeutic efficacy against SARS-CoV-2.

10 Aug 2022

Scientists present highly accurate novel framework for SARS-CoV-2 genomic surveillance

Researchers presented a novel framework for SARS-CoV-2 genomic surveillance based on case studies from New York, the United States, and the United Kingdom in a new study.

10 Aug 2022

Coronavirus biology: viral RNA synthesis, origin, and vaccines

Researchers analyzed the characteristics of coronaviruses and novel CoV vaccine candidates.

10 Aug 2022

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

Researchers conducted phase 3 evaluations of the immunogenicity of the two immunization timeframes of the CoronaVac COVID-19 vaccine among Chilean adults.

10 Aug 2022

A broad sarbecovirus-neutralizing antibody cocktail

Researchers present a rational approach for identifying SARS-CoV-2 receptor-binding domain-targeted broad neutralizing antibody cocktails.

9 Aug 2022

Using microrobotic platforms for endodontic therapy and diagnostics

With its irregularities and anatomical complexities, the root canal system is one of the most clinically challenging spaces in the oral cavity.

9 Aug 2022

Next-generation monoclonal antibody prevents malaria

Researchers investigate the pharmacokinetics and safety of L9LS, a monoclonal antibody to prevent malaria.

9 Aug 2022

Efficacy News and Research

Vaccines and monoclonal antibodies being developed for respiratory syncytial virus

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

OICR funding to help five research projects take the next step toward advancing cancer care

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

COVID-19 infection in pregnant women linked to increased risk of adverse outcomes

Azelastine nasal spray could decrease SARS-CoV-2 load

Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies

Scientists develop nanoantidote to reduce acidosis in critically ill COVID-19 patients

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

New compound proves to be potent against more than 300 drug-resistant bacteria

Research may lead the way to a simpler treatment for cancer

Review of natural products with promising anti-SARS-CoV-2 potential

Scientists present highly accurate novel framework for SARS-CoV-2 genomic surveillance

Coronavirus biology: viral RNA synthesis, origin, and vaccines

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

A broad sarbecovirus-neutralizing antibody cocktail

Using microrobotic platforms for endodontic therapy and diagnostics

Next-generation monoclonal antibody prevents malaria

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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