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Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

Asymptomatic COVID-19 during pregnancy could have potential long-term consequences for the baby

According to a new University of Kentucky College of Medicine study, asymptomatic COVID-19 infection during pregnancy could still have potential long-term consequences for a developing baby.

31 May 2022

The effect of CMV serostatus on humoral and cellular measures of vaccine responses after 2 and 3 doses of SARS-CoV-2 mRNA vaccines in older adults

Researchers evaluated the impact of CMV seropositivity on humoral and cellular immune responses generated after double and/or triple mRNA vaccination against SARS-CoV-2 among the elderly.

31 May 2022

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

A recent study posted to the bioRxiv* preprint server illustrated that specific chemokine antibodies aid in recognizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent individuals with a desirable disease course.

26 May 2022

Novel mechanism to turn on cancer-killing T cells identified

Over the past decade, researchers have made great strides in the development and administration of cancer immunotherapies, which use the body's own immune system to treat disease.

25 May 2022

Beckman Coulter Life Sciences announces contest, products for centrifugation milestone

Leading the way since 1947 with automation and innovation in centrifugation, Beckman Coulter Life Sciences announces a series of events to celebrate its 75th anniversary.

From Beckman Coulter Life Sciences - Flow Cytometry 25 May 2022

The impact of SARS-CoV-2 nucleocapsid protein mutations on the performance of rapid antigen tests

The study findings showed that the rapid antigen tests with the DMS approach could accurately identify antibody escape mutations in the SARS-CoV-2 N protein.

24 May 2022

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Primary immunodeficiency disorders (PID) can result in chronic and sometimes life-threatening infections. More than 450 PIDs have been described, but timely and accurate diagnoses remain a challenge.

23 May 2022

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers observed SARS-CoV-2 downregulates the expression of MHC class I molecules.

23 May 2022

Natural immunity weak and short-lived in unvaccinated after Omicron infection

In a recent study posted to the journal Nature, researchers showed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron infection without SARS-CoV-2 vaccination conferred poor cross-variant neutralizing capacities.

20 May 2022

L452R mutation a key player in the evolution of SARS-CoV-2

In a recent study published in the bioRxiv* preprint server, researchers analyzed the characteristics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron subvariants BA.4, BA.5, and BA.2.12.1.

19 May 2022

Kyunurenic acid in cardiovascular therapy

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of kynurenic acid on ischemic damage to the heart.

19 May 2022

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers analyze the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of MHC-I.

19 May 2022

Researchers explore SARS-CoV-2 infection in lung myeloid cells

Scientists discuss how SARS-CoV-2 utilizes myeloid cells to allow for the subsequent viral colonization in the lungs.

19 May 2022

Scientists investigate relevance of COVID-19 vaccine-mediated T cell immunity to SARS-CoV-2 variants

Researchers showed the significance of T cell-based immunity against the SARS-CoV-2 variants exhibiting evasion to antibody-centric immunity.

19 May 2022

SARS-CoV-2 Omicron found to be more immune evasive than other variants among mild COVID-19 convalescent patients

Researchers evaluated the humoral and T lymphocyte immune responses against SARS-CoV-2 variants of concern among mild COVID-19 convalescent patients in South Australia.

19 May 2022

Immunity conferred by COVID-19 vaccines in solid organ transplant recipients

In a recent study posted to the medRxiv* preprint server, researchers estimated the humoral immunity imparted by the two/three doses of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in solid organ transplant recipients (SOTRs).

18 May 2022

Researchers develop treatment that suppresses mutational escape of SARS-CoV-2

Researchers from Xiamen University have created a new treatment that is less likely to be affected by mutations in the receptor-binding domain of SARS-CoV-2.

17 May 2022

A study of SARS-CoV-2-mRNA booster vaccinations in immunocompromised patients

In a recent study published in the journal Frontiers in Immunology, researchers assessed the immune responses induced by vaccination with the messenger ribonucleic acid (mRNA)-1273 vaccine or the BNT162b2 vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among immunocompromised individuals.

17 May 2022

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

Researchers compared the immunogenicity of or and reactogenicity to the BNT162b2 vaccine in Japanese adults and elders.

16 May 2022

Cytometry News and Research

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Asymptomatic COVID-19 during pregnancy could have potential long-term consequences for the baby

The effect of CMV serostatus on humoral and cellular measures of vaccine responses after 2 and 3 doses of SARS-CoV-2 mRNA vaccines in older adults

After SARS-CoV-2 infection, anti-chemokine antibodies correlate with better outcomes

Novel mechanism to turn on cancer-killing T cells identified

Beckman Coulter Life Sciences announces contest, products for centrifugation milestone

The impact of SARS-CoV-2 nucleocapsid protein mutations on the performance of rapid antigen tests

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Natural immunity weak and short-lived in unvaccinated after Omicron infection

L452R mutation a key player in the evolution of SARS-CoV-2

Kyunurenic acid in cardiovascular therapy

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers explore SARS-CoV-2 infection in lung myeloid cells

Scientists investigate relevance of COVID-19 vaccine-mediated T cell immunity to SARS-CoV-2 variants

SARS-CoV-2 Omicron found to be more immune evasive than other variants among mild COVID-19 convalescent patients

Immunity conferred by COVID-19 vaccines in solid organ transplant recipients

Researchers develop treatment that suppresses mutational escape of SARS-CoV-2

A study of SARS-CoV-2-mRNA booster vaccinations in immunocompromised patients

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

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