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How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

One of the most challenging tasks of physicians has been differentiating between persistent COVID-19 and SARS-CoV-2 reinfection. Recently, a team of researchers analyzed SARS-CoV-2 sequences from the publicly available reports on reinfection and persistence. They further characterized the markers of reinfecting sequences and studied the mutation rate in newly evolved persistent variants.

8 Mar 2021

Saliva testing has high accuracy in detecting early cases of SARS-CoV-2

New research finds saliva testing has a high sensitivity for detecting severe acute respiratory syndrome 2 (SARS-CoV-2) in both symptomatic and asymptomatic patients.

7 Mar 2021

Children may transmit SARS-CoV-2 at same level as adults, suggests study

Researchers studied SARS-CoV-2 viral loads in over a thousand individuals, including both adults and children. They found the loads to be comparable, suggesting they may play an equal role in COVID-19 transmission.

5 Mar 2021

COVID-19 swab testing may not be good for people with a history of sinus or skull-base surgery

People who have had major sinus surgery should consult their ENT doctor before undergoing COVID-19 swab testing, new research indicates.

4 Mar 2021

Delayed detection of oral fluid anti-SARS-CoV-2 antibodies increases the time to viral clearance

A prospective observational study has revealed that the late appearance of anti-SARS-CoV-2 antibodies in oral fluid, absence of fever as an early symptom, and elevated BMI are associated with delayed clearance of viral RNA in mild to moderate COVID-19 patients.

4 Mar 2021

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

A new preprint on the medRxiv* server discusses how the underlying disease mechanisms are regulated such that the local or mucosal immune response is distinct from the systemic response.

4 Mar 2021

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

New research, published on medRxiv preprint server, has reported the effect of prolonged SARS-CoV-2 infection in immunocompromised children and young adults.

4 Mar 2021

Obesity may reduce COVID-19 vaccine efficacy, say researchers

A startling indicates that obesity may reduce the immune response to the current COVID-19 vaccines, along with other factors like age and sex. This could have significant implications for vaccination strategies in obese people.

3 Mar 2021

Quantifying SARS-CoV-2 viral load in hospitalized patients

A new paper, published on the medRxiv preprint server, investigates the role of subgenomic RNA transcripts in SARS-CoV-2 infection. Earlier, scientists believed that subgenomic RNA could be traceable infective markers to monitor infectivity.

2 Mar 2021

Novel dual-targeting drug could become a next-generation treatment for EBV-related cancers

A Hong Kong Baptist University-led research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein-Barr virus (EBV).

2 Mar 2021

KAUST researchers develop a safe, fast and cheap testing method to detect viruses

A safe, fast and cheap testing method that uses magnetic nanoparticles to detect viruses in both clinical and wastewater samples has been developed by KAUST researchers.

25 Feb 2021

Study of children hospitalized with COVID-19 shows 2% mortality

The COVID-19 pandemic caused by SARS-CoV-2 has been observed to be less serious in infants and children. However, this age group is also subject to certain complications following infection. A new study describes the findings of an observational study of children hospitalized with SARS-CoV-2 infection in several different hospitals across three countries.

25 Feb 2021

Lab study of South African SARS-CoV-2 variant and Moderna vaccine: reduced neutralization, but still protective

Researchers from the US recently compared antibody binding and viral neutralization against 2 SARS-CoV-2 variants that emerged in different parts of the world. The researchers used sera from spike mRNA vaccinated and naturally infected individuals against a circulating B.1 variant and the emerging B.1.351 variant. The study is published on the preprint server bioRxiv.

24 Feb 2021

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

A team of scientists from the United States recently investigated the mutational signatures in the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein.

23 Feb 2021

Failed antiviral response in nasal mucosa may predict severe COVID-19

Researchers in the United States have conducted a study suggesting that the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within nasal mucosa is a key determinant of clinical trajectory in coronavirus disease 2019 (COVID-19).

22 Feb 2021

Study profiles the nose to predict immune response during COVID-19

SARS-CoV-2 resides in mucous membranes, making it easy to detect viral load in the nasal cavities. An international group of researchers has characterized the immunological and diagnosis characteristics of patients who may have or are confirmed with SARS-CoV-2 infection. The team found a distinct nasal cytokine profile that could help identify patients at risk for high inflammatory responses to SARS-CoV-2 infection.

22 Feb 2021

Study identifies immune profile of people with severe COVID-19

A team of researchers at Georgetown University Medical Center, USA, investigated how SARS-CoV-2 affects the immune system’s response during and after infection and contributes to the severity of COVID-19.

22 Feb 2021

Domestic dogs unlikely to transmit SARS-CoV-2, say researchers

Researchers in Spain and Germany have conducted a study showing that domestic dogs are unlikely to contribute to the transmission and community spread of SARS-CoV-2 – the agent that causes COVID-19.

19 Feb 2021

Virus transmission by dental tools and prevention by antiviral agent

Researchers at the University of Ljubljana have demonstrated how a virus can spread by droplets during ultrasonic scaler (USS) operation and how this spread can be mitigated by merely substituting the irrigant with clinical virucidal agents, namely sodium hypochlorite and EOW (Electrolyzed Oxidizing Water).

16 Feb 2021

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Researchers at Icahn School of Medicine at Mount Sinai in New York have provided evidence suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – was infecting people in New York City (NYC) at least one month before the first case was officially documented in the city.

14 Feb 2021

Nasopharyngeal News and Research

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

Saliva testing has high accuracy in detecting early cases of SARS-CoV-2

Children may transmit SARS-CoV-2 at same level as adults, suggests study

COVID-19 swab testing may not be good for people with a history of sinus or skull-base surgery

Delayed detection of oral fluid anti-SARS-CoV-2 antibodies increases the time to viral clearance

Novel host-viral-microbiome interactions during COVID-19 may determine outcome

Study reports persistent SARS-CoV-2 with increasing viral variants in pediatric patients

Obesity may reduce COVID-19 vaccine efficacy, say researchers

Quantifying SARS-CoV-2 viral load in hospitalized patients

Novel dual-targeting drug could become a next-generation treatment for EBV-related cancers

KAUST researchers develop a safe, fast and cheap testing method to detect viruses

Study of children hospitalized with COVID-19 shows 2% mortality

Lab study of South African SARS-CoV-2 variant and Moderna vaccine: reduced neutralization, but still protective

L452R mutation potentially favors adaptive evolution of SARS-CoV-2

Failed antiviral response in nasal mucosa may predict severe COVID-19

Study profiles the nose to predict immune response during COVID-19

Study identifies immune profile of people with severe COVID-19

Domestic dogs unlikely to transmit SARS-CoV-2, say researchers

Virus transmission by dental tools and prevention by antiviral agent

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

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