Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Clinical trial shows type-1 diabetes patients treated with teplizumab exhibit greater response to therapy

Primary results from a new clinical trial show that patients with type 1 diabetes treated with the monoclonal antibody teplizumab (MacroGenics, Inc.) exhibit greater preservation of C-peptide, a biomarker of islet cell function, compared to controls.

20 Aug 2013

Interactions between sympathetic neurons and pancreatic cells have implications for organ development

The human body is a complicated system of blood vessels, nerves, organs, tissue and cells each with a specific job to do. When all are working together, it's a symphony of form and function as each instrument plays its intended roles.

17 Aug 2013

Study: Type 2 diabetic patients treated with DPP-4 linagliptin experience reductions in blood glucose levels

Data published in The Lancet showed that elderly people with Type 2 Diabetes (T2D) treated for 24 weeks with the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin, marketed by Boehringer Ingelheim and Eli Lilly and Company, experienced significant reductions in blood glucose levels (HbA1c) compared with those receiving placebo.

17 Aug 2013

Researcher receives $3.52 million grant to study epicardial fat in arteries of heart

It's no secret that a diet high in fat and sugar can lead to extra fat around the waistline. But it's what the diet will do to a specific type of fat around the heart that caught the attention of a group of Creighton researchers.

16 Aug 2013

Sanford-Burnham, Pfizer collaborates to identify therapeutic targets for treating obesity, diabetes

Sanford-Burnham Medical Research Institute (Sanford-Burnham) announced that it has entered into a collaboration with Pfizer Inc. to identify new therapeutic targets for preventing and treating complications of obesity and diabetes.

14 Aug 2013

Managing insulin levels through meal timing boosts ovulation in women with PCOS

Polycystic Ovarian Syndrome (PCOS), a common disorder that impairs fertility by impacting menstruation, ovulation, hormones, and more, is closely related to insulin levels. Women with the disorder are typically "insulin resistant" - their bodies produce an overabundance of insulin to deliver glucose from the blood into the muscles.

14 Aug 2013

State highlights: Texas waits for feds' ok on higher Medicaid payments

California schools may give students insulin injections and other medications without having to call in licensed nurses, the state's highest court ruled Monday. … The unanimous decision was a defeat for the powerful California Nurses Assn., which had argued that only licensed health care workers could administer medicine under a state law that bars the unauthorized practice of nursing (Dolan, 8/12).

14 Aug 2013

New test hints 3 sodas daily hurt lifespan, reproduction in mice

When mice ate a diet of 25 percent extra sugar - the mouse equivalent of a healthy human diet plus three cans of soda daily - females died at twice the normal rate and males were a quarter less likely to hold territory and reproduce, according to a toxicity test developed at the University of Utah.

14 Aug 2013

Discovery Transformation Program funds four projects for diabetes research

The Minnesota Partnership for Biotechnology and Medical Genomics announced four research projects selected for funding from the 2013 Discovery Transformation Grant Program.

13 Aug 2013

State highlights: Hundreds lost D.C. Medicaid without cause, some allege; N.Y. firms accused of political wrongdoing in Medicaid; unions fight NYC health care plan

A selection of health policy stories from the District of Columbia, New York, California, Florida, North Carolina and Colorado.

13 Aug 2013

Vitamin D supplementation does not improve blood pressure in hypertension patients

Vitamin D supplementation does not appear to improve blood pressure or markers of vascular health in older patients with isolated systolic hypertension (a common type of high blood pressure), according to a study by Miles D. Witham, Ph.D., of the University of Dundee, Scotland, United Kingdom, and colleagues.

13 Aug 2013

Sericin can decrease blood glucose levels and alleviate diabetic hippocampal damage

Preliminary studies by Dr. Zhihong Chen and colleagues from Chengde Medical College have shown that sericin might improve aberrant Akt signaling, decrease heme oxygenase-1 expression in the hippocampus and cerebral cortex, and reduce the apoptosis of hippocampal neurons in diabetic rats, thus protecting the nervous system.

9 Aug 2013

New bio-artificial "encapsulife" pancreas points to cure for diabetes

The Squash Diabetes Campaign, launched by the Georgetown University Women's Squash Team* in December 2012 and sponsored by New Generation Foundation, today announced a $125,000 grant provided by the Chicago-based Chauncey and Marion D. McCormick Family Foundation.

8 Aug 2013

Teplizumab to block type 1 diabetes proves strikingly effective in phase 2 clinical trial

An experimental drug designed to block the advance of type 1 diabetes in its earliest stages has proven strikingly effective over two years in about half of the patients who participated in the phase 2 clinical trial.

8 Aug 2013

Exercise could reduce metabolic disease complications in patients post-transplantation

New research reveals that metabolic syndrome—risk factors that can lead to heart disease and/or stroke—is common in liver transplant recipients, with rates highest at one year following the procedure.

7 Aug 2013

Exercise could help reduce metabolic syndrome problems in liver transplant recipients

New research reveals that metabolic syndrome-risk factors that can lead to heart disease and/or stroke-is common in liver transplant recipients, with rates highest at one year following the procedure.

7 Aug 2013

Mothers who breastfeed may have lower risk of Alzheimer's

The report, newly published in the Journal of Alzheimer's Disease, suggests that the link may be to do with certain biological effects of breastfeeding. For example, breastfeeding restores insulin tolerance which is significantly reduced during pregnancy, and Alzheimer's is characterised by insulin resistance in the brain.

6 Aug 2013

High-calorie breakfast protects against diabetes, hypertension and cardiovascular problems

Whether you hope to lose weight or just stay healthy, what you eat is a crucial factor. The right nutrients can not only trim your waistline, but also provide energy, improve your mood, and stave off disease. Now a Tel Aviv University researcher has found that it's not just what you eat - but when.

6 Aug 2013

Sleeping patterns of baby birds are similar to that of baby humans, find researchers

Researchers at the Max Planck Institute for Ornithology and the University of Lausanne have discovered that the sleeping patterns of baby birds are similar to that of baby mammals. What is more, the sleep of baby birds appears to change in the same way as it does in humans.

5 Aug 2013

IQWiG dossier assessment finds no added benefit of lixisenatide

Lixisenatide (trade name: Lyxumia) has been approved in Germany since February 2013 for the treatment of type 2 diabetes mellitus in combination with oral blood-glucose lowering drugs or basal insulin when these, together with diet and exercise, do not provide adequate glycaemic control. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products, the German Institute for Quality and Efficiency in Health Care examined whether this new drug offers an added benefit over the current standard therapy.

3 Aug 2013

Insulin News and Research

Further Reading

Clinical trial shows type-1 diabetes patients treated with teplizumab exhibit greater response to therapy

Interactions between sympathetic neurons and pancreatic cells have implications for organ development

Study: Type 2 diabetic patients treated with DPP-4 linagliptin experience reductions in blood glucose levels

Researcher receives $3.52 million grant to study epicardial fat in arteries of heart

Sanford-Burnham, Pfizer collaborates to identify therapeutic targets for treating obesity, diabetes

Managing insulin levels through meal timing boosts ovulation in women with PCOS

State highlights: Texas waits for feds' ok on higher Medicaid payments

New test hints 3 sodas daily hurt lifespan, reproduction in mice

Discovery Transformation Program funds four projects for diabetes research

State highlights: Hundreds lost D.C. Medicaid without cause, some allege; N.Y. firms accused of political wrongdoing in Medicaid; unions fight NYC health care plan

Vitamin D supplementation does not improve blood pressure in hypertension patients

Sericin can decrease blood glucose levels and alleviate diabetic hippocampal damage

New bio-artificial "encapsulife" pancreas points to cure for diabetes

Teplizumab to block type 1 diabetes proves strikingly effective in phase 2 clinical trial

Exercise could reduce metabolic disease complications in patients post-transplantation

Exercise could help reduce metabolic syndrome problems in liver transplant recipients

Mothers who breastfeed may have lower risk of Alzheimer's

High-calorie breakfast protects against diabetes, hypertension and cardiovascular problems

Sleeping patterns of baby birds are similar to that of baby humans, find researchers

IQWiG dossier assessment finds no added benefit of lixisenatide

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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