Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Study shows older lung recipients can achieve outcomes comparable to youth

Today at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual meeting and Scientific Sessions, transplant specialists Brian Keller, MD, PhD, and Thomas Egan, MD debated an ethically fraught question: How old is too old for a lung transplant?

22 Apr 2026

Donor-derived dendritic cells teach the immune system to accept new livers

UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a unique "immune priming" therapy.

17 Apr 2026

Very high prenatal PFAS exposure increases childhood asthma risk

High prenatal exposure to PFAS linked to increased childhood asthma risk, highlighting concerns over 'forever chemicals' and early-life environmental impacts.

14 Apr 2026

New project aims to improve aggressive breast cancer diagnosis

Breast cancer is the most common form of cancer in women. According to the World Health Organization, in 2022, around 2.3 million women were diagnosed with breast cancer, and the disease caused about 670,000 deaths worldwide.

11 Apr 2026

Review identifies TREM-1 as key amplifier of inflammatory diseases

Published in Current Molecular Pharmacology, a comprehensive review by Eman R. Al Sawy and colleagues from Cairo University consolidates evidence on the triggering receptor expressed on myeloid cells-1 (TREM-1) as a central amplifier of inflammatory responses.

7 Apr 2026

ASH releases updated recommendations for severe acquired aplastic anemia care

The American Society of Hematology (ASH) released guidelines on the diagnosis and management of severe acquired aplastic anemia, a rare and life-threatening bone marrow failure disorder.

1 Apr 2026

Systematic review identifies stress-induced biological triggers in oncology

Stress is a constant companion in the oncologist's office. It appears at the time of diagnosis, increases with each stage of treatment, and often does not resolve even after therapy formally ends. It accompanies therapeutic decisions, waiting for test results, fear of recurrence, and changes in daily functioning. Studies show that chronic stress can trigger biological processes that promote disease progression and weaken the body's defenses.

25 Mar 2026

Lab-grown food pipe offers hope for children with esophageal conditions

Scientists from Great Ormond Street Hospital (GOSH) and University College London (UCL) have created the first lab‑grown esophagus - the food pipe - shown to safely replace a full section of the organ and restore normal function, including swallowing, in a growing animal without the need for immunosuppression.

23 Mar 2026

Protein targeted by cancer drugs may help the body fight influenza

A protein already targeted by FDA-approved cancer drugs may also help the body fight influenza, according to new research from The Jackson Laboratory (JAX).

18 Mar 2026

New strategy boosts immunotherapy against aggressive ovarian cancer

Cells in our immune system are best known for providing security against external invaders such as bacteria and viruses. These immune cells also guard against internal threats, including cancerous tumors.

5 Mar 2026

Researchers identify TRIM13 protein as key driver of immune suppression in sepsis

Dendritic cells (DCs) are increasingly recognized as important contributors to sepsis-associated immune dysfunction.

4 Mar 2026

How zinc deficiency could worsen heart inflammation and what that means for patients

This review examines how zinc regulates inflammatory and redox signaling pathways involved in myocarditis and pericarditis, highlighting mechanisms such as NF-κB inhibition and the redox zinc switch. The authors conclude that maintaining optimal zinc status may support cardiovascular resilience, while emphasizing that clinical translation requires further targeted trials.

1 Mar 2026

Disrupted lymphatic vessels may drive chronic organ transplant rejection

Despite advances in the field of organ transplantation, long-term organ rejection that can become apparent a decade or more after a heart or lung transplant remains a common problem for patients.

25 Feb 2026

Fred Hutch scientists reach crucial milestone in blocking Epstein Barr virus

Fred Hutch Cancer Center scientists reached a crucial milestone in blocking Epstein Barr virus (EBV), a pathogen estimated to infect 95% of the global population that is linked to multiple types of cancer, neurodegenerative diseases and other chronic health conditions.

17 Feb 2026