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Understanding mitochondrial biology in alcohol-associated liver disease and cancer

For decades, giant mitochondria-known as megamitochondria-have been recognized in liver biopsies from patients with alcohol-associated liver disease (ALD).

1 Jun 2026

Scientists uncover shared gene signatures that reveal how mammals age

Researchers mapped more than 11,000 transcriptomes across mice, rats, macaques, and humans, revealing conserved molecular signatures of aging and mortality across tissues, species, and cell types. The study developed interpretable transcriptomic clocks that track age, mortality-related molecular change, chronic disease signals and responses to lifespan-altering interventions.

29 May 2026

Gum disease pathogen may drive Alzheimer’s through microglial ferroptosis pathway

Alzheimer's disease (AD), the leading cause of dementia, is projected to affect 152 million individuals worldwide by 2050; yet its pathogenesis remains poorly understood and effective treatments are lacking.

24 May 2026

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which Pim1 regulated Th17 cell differentiation through mitochondrial metabolism.

22 May 2026

Recent advancements in the development of models to study primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a rare non-communicable disorder that affects the liver. Chronic inflammation in and around the bile duct is followed by the development of fibrotic obstructions within the duct, causing bile to accumulate within the liver.

19 May 2026

New AI framework predicts how cells make fate decisions

Scientists at the Stowers Institute for Medical Research, Helmholtz Munich, the Technical University of Munich, and the University of Oxford have developed RegVelo - a new AI framework that simultaneously models cellular dynamics and gene regulation, enabling researchers to predict, simulate, and experimentally validate how cells make fate decisions.

11 May 2026

Methylmercury may harm metabolism beyond its known neurological effects

Methylmercury can accumulate in water environments and enter the food chain. Human exposure is of particular concern in communities affected by contaminated rivers, industrial pollution, artisanal gold mining and environmental disasters.

7 May 2026

KIF13B protects heart function during sepsis by regulating lipid metabolism

Sepsis, a life-threatening condition caused by dysregulated host response to infection, remains a major cause of global mortality.

5 May 2026

Intercellular heme transfer pathway sustains red blood cell production under stress

Scientists have long been puzzled by how maturing red blood cells manage to produce all the hemoglobin they need to carry oxygen to tissues, even after shedding the vital structures they need to produce it.

25 Apr 2026

Researchers discover how stress signals weaken the aging immune system

As we age, our ability to maintain healthy blood and a strong immune system gradually declines, largely because hematopoietic stem cells (HSCs), the cells responsible for producing all blood cell types, begin to lose their effectiveness. Normally, HSCs can both self-renew and generate a balanced mix of blood cells, but over time they produce fewer new cells, favor certain cells such as myeloid cells over lymphoid cells, and struggle to support a robust immune response.

16 Apr 2026

Decoy strategy boosts natural bacteria to clean polluted soils

Aromatic compounds, such as dioxins and benzene, are major soil pollutants. Their high chemical stability makes them resistant to microbial and chemical degradation, leading to toxic accumulation in the soil.

11 Apr 2026

Researchers discover how motor proteins selectively transport neuronal cargo

Intracellular transport is a vital process that allows cells to move proteins and other molecules to specific locations.

10 Apr 2026

Study maps DNA methylation changes driving MDS stem cell dysfunction

Published on April 01, 2026, in Volume 2, article number 19 of the journal Immunity & Inflammation, a collaborative team led by Prof. Cao at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, along with Dr. Liangding Hu at the Fifth Medical Center of Chinese PLA General Hospital, and Professors Qian Zhang and Yanmei Han at the National Key Laboratory of Immunity and Inflammation, Naval Medical University, has generated the first base-resolution DNA methylome of human MDS HSCs.

9 Apr 2026

DNASE1L2 identified as a dynamic biomarker for TB progression

Tuberculosis (TB) remains one of the world's most serious public health threats, with approximately one-quarter of the global population infected with Mycobacterium tuberculosis. While most infections remain latent (LTBI), individuals with LTBI are at risk of progressing to active TB and potentially becoming new sources of transmission.

31 Mar 2026

Blocking a single protein could make hidden HPV-positive tumors vulnerable to treatment

A team of scientists at Henry Ford Health + Michigan State University Health Sciences have uncovered a mechanism that allows certain head and neck cancers to hide from the immune system, a discovery that could change how some of the most treatment resistant tumors are approached.

18 Mar 2026

Scientists show gut bacteria can reach the brain in mice and reveal a potential vagus nerve pathway

Researchers found that very small numbers of gut bacteria can translocate to the brain in mice, particularly when gut barrier permeability increases due to a Paigen diet. Evidence suggests the vagus nerve may serve as a partial route for this gut-to-brain microbial movement.

15 Mar 2026

Targeting IGF2BP2 improves anti-angiogenic therapy effectiveness in colorectal cancer

A recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment in colorectal cancer (CRC).

10 Mar 2026

EVA1A regulates fatty acid transporter CD36 in fatty liver disease

Metabolic Dysfunction-Associated Steatotic Liver Disease（MASLD） is characterized by excessive accumulation of lipids in hepatocytes and is closely associated with the rapid rise in insulin resistance, obesity, and diabetes prevalence, making it one of the most common chronic liver diseases worldwide.

9 Mar 2026

STING agonists exert potent antitumor effects against nervous system tumors

The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses.