Tumor Necrosis Factor News and Research

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How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026

Study finds long COVID leaves a distinct immune signature in the blood

Researchers identified a small panel of inflammatory and neurology-related blood proteins that may help distinguish long COVID from recovery or no prior infection, while also showing that booster vaccination did not appear to worsen these protein responses in this cohort. The study also found that immune responses after reinfection differed from those seen after the first SARS-CoV-2 infection, suggesting altered long-term immune behavior in some previously infected individuals.

14 Apr 2026

SARS-CoV-2 rarely reaches first-trimester placentas but still disrupts early pregnancy immunity

Researchers analyzing 761 first-trimester pregnancies found that SARS-CoV-2 was rarely detected in placental tissues, suggesting in utero transmission early in pregnancy is uncommon. However, maternal infection was linked to immune dysregulation at the maternal-fetal interface, altered trophoblast signaling, and inflammatory changes that could affect placental development.

14 Apr 2026

Parents’ intake of sugar substitutes may influence offspring gut biology, study finds

A mouse study in Frontiers in Nutrition found that parental sucralose and stevia intake altered gut microbiota, short-chain fatty acids, and gene expression across generations, with sucralose showing the stronger and more persistent effects. The changes were transmitted to offspring not directly exposed to the sweeteners, although several effects were attenuated by the F2 generation.

13 Apr 2026

Microplastics found in human bile may be associated with gallstones

Findings show microplastics in bile may trigger cellular senescence, suggesting a link to gallstone disease and highlighting the need for further research.

9 Apr 2026

CIPHER-seq technology reveals how immune cells communicate during treatment

A new single-cell technology is giving scientists their clearest view yet of immune cell behavior-capturing not just genetic intent but real-time activity.

8 Apr 2026

How gut imbalance may drive obesity, diabetes, and heart disease

A new review argues that gut dysbiosis is closely linked to metabolic dysfunction through intertwined effects on inflammation, oxidative stress, gut barrier integrity, microbial metabolites, and epigenetic regulation. It also highlights microbiome-targeted strategies such as high-fiber diets, probiotics, prebiotics, postbiotics, exercise, and fecal microbiota transplantation as promising ways to support metabolic health.

30 Mar 2026

Heavily processed foods may raise heart disease risk beyond poor nutrition alone

A 2026 review in Cardiology in Review reports that higher intake of ultra-processed foods is consistently associated with greater risks of cardiovascular disease, stroke, and cardiovascular mortality across cohort studies and meta-analyses. The paper also highlights plausible mechanisms involving gut dysbiosis, oxidative stress, and NF-κB-driven inflammation, with additives such as emulsifiers, preservatives, dyes, and sweeteners discussed as potential contributors.

26 Mar 2026

Can camel milk improve health? Review highlights benefits but warns against drinking it raw

A narrative review in Food Science & Nutrition examined studies published from 2000 to 2025 and found that camel milk contains bioactive compounds with potential glycemic, anti-inflammatory, gut, and other health benefits. It also stressed that raw, unpasteurized camel milk poses microbial and zoonotic risks, underscoring that safety remains a key part of the story.

25 Mar 2026

Immune cells use neurotransmitters to regulate health and disease

The article, titled "Emerging roles of immune cell-derived neurotransmitters in immunity and disease," published on March 17, 2026, in Immunity & Inflammation, provides a timely and authoritative review of how innate and adaptive immune cells-including macrophages, dendritic cells, natural killer cells, T cells, and B cells-produce and respond to classic neurotransmitters.

25 Mar 2026

New skin atlas maps over one million cells across the human body

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body.

25 Mar 2026

Palmatine improved fatty liver markers in a preclinical type 2 diabetes study

Researchers used a bioinformatics-plus-rat-model approach to investigate how palmatine may help treat T2DM-associated MASLD, identifying five core targets: ADRB2, BCL3, EGR1, FOS, and MAP3K8. In rats, palmatine improved liver injury, inflammation, oxidative stress, glycolipid metabolism, steatosis, and fibrosis, while reducing apoptosis-related signaling, providing a preclinical foundation for further therapeutic study.

23 Mar 2026

Protein targeted by cancer drugs may help the body fight influenza

A protein already targeted by FDA-approved cancer drugs may also help the body fight influenza, according to new research from The Jackson Laboratory (JAX).

18 Mar 2026

Can eating almonds reduce inflammation in obesity?

Adding almonds to the diet of adults with obesity enhances inflammatory cytokine profiles and diet quality, highlighting a simple anti-inflammatory strategy.

12 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

Nearly 70 weeks after infection, long COVID patients show no detectable inflammation in blood tests

A controlled Norwegian case-control study examined circulating biomarkers of inflammation and neuronal injury in people with long COVID about 69 weeks after infection. The researchers found no significant differences in systemic inflammatory or neuroinjury markers compared with recovered controls after statistical correction.

4 Mar 2026

How zinc deficiency could worsen heart inflammation and what that means for patients

This review examines how zinc regulates inflammatory and redox signaling pathways involved in myocarditis and pericarditis, highlighting mechanisms such as NF-κB inhibition and the redox zinc switch. The authors conclude that maintaining optimal zinc status may support cardiovascular resilience, while emphasizing that clinical translation requires further targeted trials.

1 Mar 2026

Tumor Necrosis Factor News and Research

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

Study finds long COVID leaves a distinct immune signature in the blood

SARS-CoV-2 rarely reaches first-trimester placentas but still disrupts early pregnancy immunity

Parents’ intake of sugar substitutes may influence offspring gut biology, study finds

Microplastics found in human bile may be associated with gallstones

CIPHER-seq technology reveals how immune cells communicate during treatment

How gut imbalance may drive obesity, diabetes, and heart disease

Heavily processed foods may raise heart disease risk beyond poor nutrition alone

Can camel milk improve health? Review highlights benefits but warns against drinking it raw

Immune cells use neurotransmitters to regulate health and disease

New skin atlas maps over one million cells across the human body

Palmatine improved fatty liver markers in a preclinical type 2 diabetes study

Protein targeted by cancer drugs may help the body fight influenza

Can eating almonds reduce inflammation in obesity?

How somatic mutations shape disease and reveal new drug targets

Nearly 70 weeks after infection, long COVID patients show no detectable inflammation in blood tests

How zinc deficiency could worsen heart inflammation and what that means for patients

Targeted PET/CT tracer improves early prediction of treatment response in rheumatoid arthritis patients

Study finds brain changes related to worse memory in football players with repetitive head impacts

Discovery offers hope for reducing immune-related heart risks in cancer patients

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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