Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Research offers hope for patients affected by rare, hereditary metabolic disease

Methylmalonic aciduria (MMA) is a metabolic disorder that affects approximately one in 90,000 newborns; both parents must carry a genetic predisposition to the disease.

26 Jan 2023

Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies

Researchers reported on AGORA2, an expansion of their previously published resource, AGORA, of genomewide metabolic reconstructions of human intestinal microbes.

26 Jan 2023

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

About 196 million women worldwide suffer from endometriosis, a condition that typically causes pelvic pain and infertility.

25 Jan 2023

Process analytical technologies and monitoring inline R&D biopharma processes with Raman spectroscopy

Established in 2004, process analytical technology (PAT), a quality assurance program for the pharmaceutical industry developed by the US Food and Drug Administration, enables pharmaceutical manufacturers to control critical process parameters (CPPs).

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 25 Jan 2023

Single drop of blood can be used to measure thousands of molecules

Researchers at Stanford Medicine have shown they can measure thousands of molecules — some of which are signals of health — from a single drop of blood.

25 Jan 2023

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Modulating the lipid composition to treat bronchial asthma

Bronchial asthma, a chronic inflammatory disease of the airways that is reversible in certain cases, usually presents with cough, difficulty of breathing, and wheezing.

24 Jan 2023

Researchers identify plasma metabolomic markers for the Mediterranean diet among pregnant women

A recent study identifies blood metabolomic markers and metabolite panels linked to the Mediterranean diet in pregnant women.

17 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

Chemicals accumulated in the vagina may contribute to spontaneous preterm birth

Chemicals that accumulate in the vagina, potentially originating from personal care products, may contribute to spontaneous preterm birth, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

13 Jan 2023

Study finds fewer cases of melanoma among regular users of vitamin D supplements

Fewer cases of melanoma were observed among regular users of vitamin D supplements than among non-users, a new study finds.

9 Jan 2023

Does the Mediterranean diet improve cognition?

A recent study looked at the metabolite output in people on an MD and the associations between this profile and the cognitive performance in this group.

9 Jan 2023

Cells live longer when they exchange metabolic products with each other

When cells exchange metabolic products with other cells, they live longer. This new finding comes from a research team at Charité – Universitätsmedizin Berlin, which made the discovery in a study using yeast cells.

6 Jan 2023

Mediterranean diet may benefit health in part by incorporating moderate wine consumption

Many public health warnings have been issued against alcohol consumption, even in small quantities, though the evidence for such strict limits is controversial. The current study, published in the MDPI journal Nutrients, is a narrative review focused on clearing up some of the confusion associated with alcoholic drinks.

4 Jan 2023

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Researchers used a multi-omics approach to profile the gut microbiomes and metabolomes of mothers and infants to determine the vertical and horizontal transmission of bacterial species and strains as well as individual genes and understand the dynamics of the gut microbiome assembly that shape the development of the infant before and after birth.

29 Dec 2022

Study shows how a specific gut microbe-generated byproduct is linked to heart failure risk

New research at Cleveland Clinic expands the link between what we eat and how the gut microbiome impacts our susceptibility to develop different diseases – in this case, how a specific gut microbe-generated byproduct is linked to heart failure risk.

16 Dec 2022

Blood-based dietary signatures accurately predict both diet and risk of diseases

When it comes to studying food and diet, it's difficult to know what people are eating – let alone their risk of disease caused by what they eat.

15 Dec 2022

Researchers develop a self-powered ingestible sensor system to monitor intestinal metabolites

Engineering researchers have developed a battery-free, pill-shaped ingestible biosensing system designed to provide continuous monitoring in the intestinal environment.

1 Dec 2022

Grape consumption protects against ultraviolet UV damage to the skin

A recent human study published this week in the scientific journal Antioxidants found that consuming grapes protected against ultraviolet (UV) damage to the skin. Study subjects showed increased resistance to sunburn after consuming 2 ¼ cups of grapes every day for two weeks.

30 Nov 2022

New urinary biomarkers could help monitor potential abuse of emerging synthetic cannabinoids

A team of scientists from the National University of Singapore (NUS) has successfully identified the urinary biomarkers of an emerging subclass of synthetic cannabinoids, called OXIZID, to monitor potential abuse.