Preclinical News and Research

RSS

DNA barcoding can be used to track cancer cells in solid and liquid biopsies

Australian scientists have discovered that DNA barcoding can be used to track cancer cells in solid and liquid biopsies, empowering future research into more reliable breast cancer diagnosis and treatment strategies.

11 Feb 2026

University of Missouri launches first on-campus radiopharmaceutical clinical trial

In a major leap for cancer care at the University of Missouri, the School of Medicine and MU Health Care have launched their first clinical trial using a leading-edge therapy manufactured on campus at the university's research reactor.

10 Feb 2026

Dual targeting strategy suppresses pancreatic cancer cell growth

A new research paper was published in Volume 13 of Oncoscience on January 28, 2026, titled "Dual targeting of oncogenic microtubules and mitochondria in PDAC."

10 Feb 2026

US cancer institute studying ivermectin’s ‘ability to kill cancer cells’

The National Cancer Institute, the federal research agency charged with leading the war against the nation's second-largest killer, is studying ivermectin as a potential cancer treatment, according to its top official.

10 Feb 2026

Synthace collaborates with Charles River to offer the global pharma industry more robust, faster and cost-effective assays

Synthace, the leader in software and services for assay development, today announced a collaboration with Charles River Laboratories International, Inc. (Charles River), a leading global drug discovery, development, testing, and manufacturing solutions provider.

9 Feb 2026

Chronic brain compression triggers neuron death through multiple pathways

To think, feel, talk and move, neurons send messages through electrical signals in the brain and spinal cord.

9 Feb 2026

Tumor-targeted chimeric drug increases efficacy and limits side effects

Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively.

7 Feb 2026

Implantable immune scaffold predicts type 1 diabetes weeks before symptoms

The study highlights a presymptomatic phase in type 1 diabetes progression, using immune niches to track immune changes before blood sugar abnormalities.

4 Feb 2026

Engineered liver tissue model mimics early metabolic liver disease

More than 100 million people in the United States suffer from metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by a buildup of fat in the liver.

3 Feb 2026

Single-dose HIV vaccine candidate induces neutralizing antibodies

Scientists at The Wistar Institute have developed an HIV vaccine candidate that achieves something never before observed in the field: inducing neutralizing antibodies against HIV after a single immunization in nonhuman primates.

3 Feb 2026

Aging alters social preferences through distinct brain mechanisms

The loss of social connectedness as people age increases the odds of cognitive-related disorders and can worsen health outcomes in older populations. But is there a direct relationship between social behavior and cognition? Subhadeep Dutta Gupta, Peter Rapp, and colleagues, from the National Institute on Aging, developed a rat model to probe social cognition in the aging brain.

2 Feb 2026

New platform improves prediction of human antibody drug responses

An international research consortium, led by scientists at VIB and UGent, has developed a new platform that could change how antibody medicines are tested and brought to patients. The

1 Feb 2026

Palbociclib improves progression-free survival in HER2 positive breast cancer

PrECOG, LLC, today announced the publication of final results from the pivotal phase 3 PATINA study in the New England Journal of Medicine (NEJM).

30 Jan 2026

Hippocampus reorganizes memories to anticipate future outcomes, study finds

A preclinical study published in Nature has found evidence that the hippocampus, the brain region that stores memory, also reorganizes memories to anticipate future outcomes.

30 Jan 2026

Two-pronged therapeutic technology for cancer wins Pfizer Prize for Biomedical Research 2026

Whereas conventional treatments such as chemotherapy and radiotherapy show their limitations in battling certain advanced cancers, immunotherapy and therapeutic vaccines have opened up a new realm of hope for patients.

29 Jan 2026

Soluble E-cadherin drives brain metastasis in aggressive inflammatory breast cancer

Researchers at The University of Texas MD Anderson Cancer Center have identified a targetable driver of brain metastases in patients with aggressive inflammatory breast cancer.

28 Jan 2026

New nanomaterial kills cancer cells via oxidative stress

Scientists at Oregon State University have developed a new nanomaterial that triggers a pair of chemical reactions inside cancer cells, killing the cells via oxidative stress while leaving healthy tissues alone.

28 Jan 2026

New peptide targets the root causes of recurring seizures

New study suggests that an experimental peptide developed at the Hebrew University may reduce recurring seizures and support brain function by targeting underlying oxidative stress and inflammation processes linked to epilepsy.

28 Jan 2026

Insilico Medicine and Qilu Pharmaceutical partner to develop AI-designed cardiometabolic drugs

Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, and Qilu Pharmaceutical Group, a major comprehensive modern pharmaceutical enterprise in China, as well as its subsidiary Shanghai Qilu Pharmaceutical Research Center, today announced a strategic partnership on innovative drug development, leveraging Insilico's proprietary Pharma.AI platform to jointly develop small molecule inhibitors, focusing on specific targets for cardiometabolic disease management.

27 Jan 2026

Gene therapy targeting connexin 43 shows promise across inherited heart diseases

University of California San Diego-led team has discovered that restoring a key cardiac protein called connexin‑43 in a mouse model can dramatically improve heart function and extend survival in several inherited forms of arrhythmogenic cardiomyopathy (ACM)

26 Jan 2026