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Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

A University of Florida Health researcher has successfully analyzed the many mutations in the omicron variant of the SARS-CoV-2 virus, a crucial step in better understanding the variant's potential threat and ways to combat it.

9 Dec 2021

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

A new study discusses the effect of the Omicron variant’s mutations on its binding efficiency to the ACE2 receptor.

9 Dec 2021

Long term vaccine response following Pfizer COVID-19 vaccination in hemodialysis patients

Researchers discuss the long-term humoral immune responses in hemodialysis patients after being vaccinated with the BNT162b2 mRNA vaccine.

9 Dec 2021

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Researchers from the Centro de Investigaciones Biológicas Margarita Salas have been investigating one of the mutations that typically appear in the Delta variant.

9 Dec 2021

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Scientists attempt to understand the evolution of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2.

9 Dec 2021

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of "intruding" viruses like human immunodeficiency virus (HIV).

9 Dec 2021

Kinetics and persistence of SARS-CoV-2 antibody responses

New study findings indicate that antibody detection shows a distinct pattern depending on the type of antibody detected, the target antigen, the test design, antibody avidity level, and COVID-19 severity.

9 Dec 2021

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

New study results provide evidence that the binding between SARS-CoV-2 RBD and host ACE2 receptor is aided by the glycosylation on each protein.

9 Dec 2021

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

Researchers have developed Nanocovax, a COVID-19 subunit vaccine based on recombinant protein technology to produce the extracellular (soluble) portion of the S protein of SARS-CoV-2.

9 Dec 2021

UVA researchers uncover common link between lupus and macular degeneration

University of Virginia School of Medicine researchers have made a discovery linking lupus, a potentially debilitating autoimmune disorder, and macular degeneration, a leading cause of blindness.

9 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Researchers from the United States, in their recent study published on the preprint server medRxiv*, have evaluated the humoral responses to third vaccine dose in nursing home residents and healthcare workers (HCW) and found that that second booster (or third vaccine dose) significantly increased anti-spike, anti-receptor binding domain (RBD), and neutralization titers in almost all nursing home residents and HCW to considerably higher levels than what was attained after the completion of the initial two-dose vaccine series.

8 Dec 2021

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

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8 Dec 2021

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

A collaborative team from the School of Medicine at the University of Cardiff, Wales and a range of US institutions used the UK's national synchrotron, Diamond Light Source, to help reveal the details of how a protein in the blood is attracted to a key component of Adenovirus based vaccines.

8 Dec 2021

New hormone may play a key role in the development of type 1 and type 2 diabetes

A newly discovered hormone named fabkin helps regulate metabolism and may play an important role in the development of both type 1 and type 2 diabetes, according to research led by the Sabri Ülker Center for Metabolic Research at Harvard T.H. Chan School of Public Health.

8 Dec 2021

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

In a new study, scientists have computationally predicted the structure of the Omicron spike RBD from available sequences and explored the dynamics of antigen-antibody interactions.

8 Dec 2021

Study identifies ORF8 protein as a key COVID-19 causing factor

New study suggests that the SARS-CoV-2 ORF8 protein is the underlying cause behind severe COVID-19 infection.

8 Dec 2021

Receptor News and Research

Analysis finds substantially more mutations in the omicron SARS-CoV-2 variant

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

Long term vaccine response following Pfizer COVID-19 vaccination in hemodialysis patients

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Kinetics and persistence of SARS-CoV-2 antibody responses

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Glycans strengthen and lengthen SARS-Cov-2 spike binding to ACE2

Immunogenicity and safety of COVID-19 subunit vaccine Nanocovax in animal models

UVA researchers uncover common link between lupus and macular degeneration

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Neutralization antibodies elevated in nursing home residents after COVID-19 mRNA boosters

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

New hormone may play a key role in the development of type 1 and type 2 diabetes

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

Study identifies ORF8 protein as a key COVID-19 causing factor

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